Biomaterials for Tissue Regeneration: Current Progress and Future Directions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (20 November 2025) | Viewed by 3204
Special Issue Editors
2. Department of Oral and Maxillofacial Surgery, Carol Davila Central Military Emergency Hospital, 010825 Bucharest, Romania
Interests: head and neck cancer; prognostic biomarkers; carcinogenesis; imaging; inflammation; salivary
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hard and soft tissue defects can arise from various causes, including congenital anomalies, trauma, tumor resection, and surgical interventions. Currently available reconstruction techniques have significant limitations, especially in large, composite defects. Often, in restorative medicine, clinicians face unique challenges due to the complex anatomy and the need to rehabilitate both the anatomy and the functionality, providing an adequate quality of life and social reintegration for the patients. A multidisciplinary approach to ensure a comprehensive evaluation and customized treatment planning to address individual patient needs is a key element for successful reconstruction. A wide range of biomaterials and, more recently, 3D bioprinting have been implemented and become crucial elements for successful reconstructions, serving as scaffolds for tissue regeneration or as implants to restore structural integrity. Tissue engineering approaches involving stem cells, growth factors, and bioactive scaffolds hold promise for enhancing tissue regeneration and improving long-term outcomes. These constructs elicit a complex biological response upon implantation. Various tangled signaling mechanisms orchestrate cellular activities, essential for tissue repair and regeneration. Different types of cells interact with biomaterials to influence the healing process. Surface properties, such as topography and chemistry, modulate cell adhesion, proliferation, and differentiation. Understanding these molecular mechanisms enables tailoring specific regenerative applications in the reconstruction of complex tissue defects.
In this Special Issue, we invite contributions that shed light on the molecular mechanisms involved in the successful reconstruction of soft and hard tissue defects. Researchers are encouraged to submit manuscripts presenting original research findings, review papers, innovative methodologies, and conceptual advances aiming to investigate and deepen the understanding of the molecular features that support an optimal restorative model.
Prof. Dr. Ana Caruntu
Prof. Dr. Horia Barbu
Guest Editors
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Keywords
- biomaterials
- biocompatibility
- tissue engineering
- tissue defect
- rehabilitation
- scaffolds
- regenerative medicine
- angiogenesis
- stem cells
- antimicrobial
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