Calcium Homeostasis of Cells in Health and Disease: Third Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 17
Special Issue Editors
Interests: skeletal muscle; intracellular calcium; excitation contraction coupling; muscle force; myopathies; aging; antioxidants
Special Issues, Collections and Topics in MDPI journals
Interests: calcium signaling; skeletal muscle; excitation-contraction coupling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue, “Calcium Homeostasis of Cells in Health and Disease: 2nd Edition”.
Whether in health or disease, calcium ions (Ca2+) play an important role in stimuli by responding to the processes of cells as a second messenger. In this process, the body maintains a low intracellular Ca2+ concentration at rest and mobilizes Ca2+ in response to stimuli, which activates cellular functions. This second-messenger role of Ca2+ was first discovered during the excitation–contraction coupling of skeletal muscle. Since then, the characteristics of Ca2+ as a second messenger (the variety of its targets, its ability to achieve quick and substantial transient and oscillatory mobilization, and its ability to cause localized and generalized cell responses) have been widely studied.
Although calcium has been extensively investigated in a variety of cells, many of its features are still uncertain; for example, what is its role in physiological and pathological circumstances? A few studies have shown that the Ca2+ homeostasis of cells changes during development and as they age. The latter is becoming increasingly important, as the Earth’s population is increasingly living longer. Thus, aging is a hot topic in research on humans. In addition, alterations in calcium homeostasis can occur in several diseases. New technological challenges and innovations in the use of calcium sensors have deepened our knowledge in this field, enabling us to study calcium concentrations outside and inside cells and even in cell organelles.
The aim of this Special Issue is to collect novel data regarding the role of calcium in the functioning of cells. We encourage the submission of manuscripts presenting innovative strategies to maintain and/or improve cell functions in aging and diseases.
Dr. Péter Szentesi
Prof. Dr. László Csernoch
Guest Editors
Manuscript Submission Information
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Keywords
- Ca2+
- calcium homeostasis
- calcium-binding proteins
- aging
- disease
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