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p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 813

Special Issue Editor


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Guest Editor
Department of Internal Medicine I, Universitätsklinikum Tübingen and M3 Research Institute, University Tübingen, 72076 Tübingen, Germany
Interests: tumor suppressors; oncogenes; anticancer; tumor formation

Special Issue Information

Dear Colleagues,

This Special Issue, titled “p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell”, is dedicated to developing understanding of the ways in which the p53 protein contributes to regulating cell responses to stimuli originating from the inside of the cell or the cellular environment. Further, its featured works explore how the perturbation of this function affects disease development and anticancer therapy. Discovered 45 years ago, the p53 protein is the most studied of all proteins involved in both tumor formation and treatment. The reason for such an elevated position is the participation of p53 in nearly all types of cellular stress coordinating cellular responses to these stimuli. Both original research articles and comprehensive reviews are welcome for submission.

Dr. Przemyslaw Bozko
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • p53
  • oncogene
  • tumor suppressor gene
  • tumor formation
  • anticancer therapy

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Published Papers (1 paper)

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10 pages, 895 KiB  
Opinion
Latest News from the “Guardian”: p53 Directly Activates Asymmetric Stem Cell Division Regulators
by Ana Carmena
Int. J. Mol. Sci. 2025, 26(7), 3171; https://doi.org/10.3390/ijms26073171 - 29 Mar 2025
Viewed by 398
Abstract
Since its discovery in 1979, the human tumor suppressor gene TP53—also known as the “guardian of the genome”—has been the subject of intense research. Mutated in most human cancers, TP53 has traditionally been considered a key fighter against stress factors by trans-activating [...] Read more.
Since its discovery in 1979, the human tumor suppressor gene TP53—also known as the “guardian of the genome”—has been the subject of intense research. Mutated in most human cancers, TP53 has traditionally been considered a key fighter against stress factors by trans-activating a network of target genes that promote cell cycle arrest, DNA repair, or apoptosis. Intriguingly, over the past years, novel non-canonical functions of p53 in unstressed cells have also emerged, including the mode of stem cell division regulation. However, the mechanisms by which p53 modulates these novel functions remain incompletely understood. In a recent work, we found that Drosophila p53 controls asymmetric stem cell division (ASCD) in neural stem cells by transcriptionally activating core ASCD regulators, such as the conserved cell-fate determinants Numb and Brat (NUMB and TRIM3/TRIM2/TRIM32 in humans, respectively). In this short communication, we comment on this new finding, the mild phenotypes associated with Drosophila p53 mutants in this context, as well as novel avenues for future research. Full article
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