Pulmonary Hypertension: Molecular Diagnosis, Pathogenesis, Biomarkers and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 October 2025) | Viewed by 2588
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pulmonary arterial hypertension (PAH) is a rare condition, characterized by high pulmonary artery pressure, leading to right ventricular (RV) dysfunction and potential life-threatening consequences. PAH involves complex mechanisms: vasoconstriction, vascular remodeling, endothelial dysfunction, inflammation, oxidative stress, fibrosis, RV remodeling, metabolic imbalance, and thrombosis. These mechanisms are mediated by several pathways, like nitric oxide and prostacyclin.
PAH falls into Group 1 of pulmonary hyperthension (PH), with specific therapies. Early and accurate diagnosis is crucial and requires clinical evaluation and right heart catheterization. Mortality rates remain high, despite the development of new classes of drugs and the recent discovery of new pathways.
This Special Issue aims to delve deeper into molecular diagnosis, pathogenesis, biomarkers and therapies of PH, presenting the main innovations on biomolecular experiments, molecular mechanisms and pathophysiology underlying the development of PH, as well as new pharmacological discoveries to counteract this condition.
Dr. Michele Correale
Guest Editor
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Keywords
- pulmonary hypertension
- pulmonary arterial hypertension
- pulmonary vascular disease
- pulmonary circulation
- cor pulmonale
- chronic lung disease
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