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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring the Cytoskeleton and Its Regulators: From Structure to Function

edited by

Wan Lee

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3806 | Submission Open

Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Treatment of Retinal Diseases

edited by

Deokho Lee

and

Livio Vitiello

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3560 | Submission Open

Keywords: nutritional supplementations; high myopia; optometry; cell therapy; drug delivery; age-related macular degeneration; glaucoma; retinal degeneration; choroidal thinning; scleral remodeling; light therapy; digital healthcare; prematurity of retionopathy; carotid artery occlusion; retinal ischemia; inflammation; eye drop

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Translational Oncology: From Molecular Basis to Therapy

edited by

Mario Cioce

and Gatti Veronica

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3480 | Submission Open

Keywords: cancer; therapy resistance; translational oncology; cancer stem cells; immunotherapy; cancer metabolism; OMICS; patient-derived-organoids; drug repositioning; TKI

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Neurological and Psychiatric Disease, 2nd Edition

edited by

Giuseppina Martella

and Maria Meringolo

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3461 | Submission Open

Keywords: Alzheimer's and Parkinson's diseases; epilepsy; migraine; essential tremors; stroke; depression; anxiety disorders; cognitive impairment

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Cages: Design, Synthesis, and Applications

edited by

Vicente Martí-Centelles

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2891 | Submission Open

Keywords: molecular cages; supramolecular chemistry; synthetic chemistry; self-assembly; molecular design; host– guest chemistry; biological applications

(This special issue belongs to the Section Macromolecules)

Pancreatic Disease: From Molecular Basis to Novel Therapies—2nd Edition

edited by

Agnieszka B. Bialkowska

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2763 | Submission Open

Keywords: pancreatitis; acinar-to-ductal neoplasia; early pancreatic neoplasia; fibroinflammatory disease; pancreatic cancer; diabetes Mellitus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2607 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Natural Compounds in Immune-Inflammatory Regulation: Mechanisms and Therapeutics

edited by Dae-Hun Park, Chun-Sik Bae and

Seung-Sik Cho

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2589 | Submission Open

Keywords: natural compound; immune-inflammatory regulation; mechanism; cytokine; NF-κ B/COX-2; PGE2

(This special issue belongs to the Section Molecular Immunology)

Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications

edited by

Ariel Fernando Castro

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2538 | Submission Open

Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression

(This special issue belongs to the Section Molecular Oncology)

Steroids in Human Disease and Health

edited by

Martin Hill

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2446 | Submission Open

Keywords: steroid metabolism; steroids and endocrinopathies; steroids and inflammation; corticosteroids; mineralocorticoids; neuroactive steroids; steroids and neuropsychiatric diseases; steroids and reproduction; steroidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases

edited by

Hsin-Hou Chang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2353 | Submission Open

Keywords: infectious diseases; circulatory dysfunction; coagulation disorders; endothelial activation; platelet aggregation; anticoagulant therapy; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioinformatics of Gene Regulations and Structure–2025

edited by

Yuriy L. Orlov

Anastasia Anashkina

and

Nikolay A. Kolchanov

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2323 | Submission Open

Keywords: gene expression regulation; bioinformatics and systems biology; NGS data analysis of gene expression; ncRNA networks; computer genomics of model organisms; fundamental biomedicine model; regulatory gene networks; AI tools in bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights into the Developmental Origins of Health and Disease, 2nd Edition

edited by

Paramjit S. Tappia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2314 | Submission Open

Keywords: Developmental Origins of Health and Disease (DOHaD); fetal development; maternal nutrition; molecular programming; epigenetic modifications; environmental exposures; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Study on Organellar Genomes of Vascular Plants

edited by

Monika Szczecińska

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2212 | Submission Open

Keywords: mitochondrial DNA (mtDNA); chloroplast DNA (cpDNA); plant evolution; plant organellar genome; genomics

(This special issue belongs to the Section Molecular Plant Sciences)

The Innate Immune System in Renal Diseases

edited by

Takashi Oda

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2161 | Submission Open

Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Biomarkers for the Diagnosis of Cancer

edited by Fernando Luiz Affonso Fonseca

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2117 | Submission Open

Keywords: biomarkers; circulating ; lab methods; diagnosis; screening

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Venom and Antivenom

edited by

Vance G. Nielsen

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1941 | Submission Open

Keywords: venom; antivenom; mass spectroscopy; spectrophotometry; thromboelastography; coagulation; neuromuscular junction

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

edited by

Nuno Taveira

and Inês Bártolo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1863 | Submission Open

Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Molecular Genetics and Genomics in Poland: 3rd Edition

edited by

Ewa Fiedorowicz

and

Anna Cieślińska

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1861 | Submission Open

Keywords: RNA; DNA; DNA structure; damage; and repair; post-translational modifications; autophagy; cell cycle; gene expression; functions and therapy; mutation; nuclear organization; polymerase; nucleic acid– protein interactions; molecular clone; sequencing analysis; epigenetics; transcriptomics; genetics of aging; genetic disorders; SNP; etc

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia

edited by Mark Slevin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1836 | Submission Open

Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies

edited by

Jacek Baj

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1770 | Submission Open

Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer

(This special issue belongs to the Section Molecular Oncology)

Enhancing Stem Cell Grafting in Tissue Regeneration and Repair

edited by

Yuanyuan Zhang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1746 | Submission Open

Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Highlights in Pathophysiology of the Musculoskeletal System, 3rd Edition

edited by

Marta Anna Szychlinska

Rosario Barone

and

Giovanna Calabrese

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1663 | Submission Open

Keywords: musculoskeletal; skeletal; tendon; ligament; intervertebral; articular cartilage; osteoarthritis; rheumatoid arthritis; sarcopenia; muscle wasting; osteoporosis; bone necrosis; synovium; pain; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Climate Change Mitigation Strategies in Grapevine Molecular, Biochemical, and Physiological Performance

edited by

Sandra Pereira

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1626 | Submission Open

Keywords: grapevine growth; climate change; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Modeling: Latest Advances and Applications, 2nd Edition

edited by

Maria Alexandra Mernea

and

Dan Florin Mihǎilescu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1543 | Submission Open

Keywords: molecular modeling; computational chemistry; drug design; material science; biomolecular interactions; algorithmic advances; theoretical chemistry; simulation techniques; predictive modeling; interdisciplinary applications

(This special issue belongs to the Section Molecular Biophysics)

Mechanisms of Resistance to Melanoma Immunotherapy

edited by Marko B. Lens

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1517 | Submission Open

Keywords: melanoma; immune checkpoint inhibitors; PD-1

(This special issue belongs to the Section Molecular Oncology)

Non-Coding RNAs’ Functionality—Diagnosis and Therapy in Cancer and Other Indications (2nd Edition)

edited by

Mohamed Raafat El-Gewely

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1500 | Submission Open

Keywords: non-coding RNAs (ncRNAs); long non-coding RNAs (lncRNAs); MicroRNAs (miRNAs); circular RNAs (circRNAs); epigenetic and post-transcriptional regulation; epithelial– mesenchymal transition (EMT); cell proliferation and Apoptosis; biomarkers and Liquid biopsy; RNA-based therapeutics; next-generation sequencing (NGS); CRISPR/Cas9 screening; single-cell RNA sequencing (scRNA-seq); RNA interference (RNAi); cancer stem cells; early cancer diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Development of Molecular Research in Animal Nutrition

edited by

Mohammad Moniruzzaman

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1467 | Submission Open

Keywords: animal nutrition; molecular biology; microbiome; feed efficiency; sustainable aquaculture; proteomics; metabolomics; molecular mechanisms; metabolic regulation; disease resistance

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Studies on Microbial Degradation of Emerging Pollutants Toxic to Human Health

edited by

Yang Yang

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1458 | Submission Open

Keywords: microbial degradation; emerging pollutants and organic pollutants; bacteria; fungi; enzyme

(This special issue belongs to the Section Molecular Microbiology)

Molecular Biology of Foodborne Pathogens: Pathogenesis and Control Strategies

edited by

Jaewoo Bai

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1431 | Submission Open

Keywords: foodborne pathogens; molecular pathogenesis; virulence factor; virulence genes; host– pathogen interaction; antimicrobial resistance; bioinformatics; omics technology; rapid detection and diagnostics; control strategies; food safety

(This special issue belongs to the Section Molecular Microbiology)

Nutrition, Inflammation, and Chronic Kidney Disease

edited by

Denise Mafra

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1406 | Submission Open

Keywords: chronic kidney disease; inflammation; nutrients; bioactive compounds

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structural Codes of Sphingolipids and Their Involvement in Diseases

edited by

Sandro Sonnino

and

Elena Chiricozzi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1232 | Submission Open

Keywords: sphingolipids; sphingolipid hydrophilic head; sphingolipid hydrophobic tail; sphingolipid signalling; sphingolipid diseases

(This special issue belongs to the Section Biochemistry)

Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

edited by

Jens Schlossmann

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1202 | Submission Open

Keywords: cyclic nucleotide; cNMP; cAMP; cGMP; cCMP; cUMP; cGAMP; signaling proteins; signal transduction pathways; scaffolds; nitric oxide; natriuretic peptides; adenylyl cyclases; guanylyl cyclases; kinases; phosphodiesterases; channels; (patho)physiology; pharmacology

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Governing Lipid Metabolism in Health and Disease

edited by

Christina E. Kostara

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1145 | Submission Open

Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs

edited by

Yoshihiro Uesawa

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1116 | Submission Open

Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research in Nanotechnology for Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1023 | Submission Open

Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition

edited by

Marko Tarle

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1008 | Submission Open

Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathology of the Placenta in Pregnancy Complications

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1007 | Submission Open

Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antibacterial Nanomaterials for Medicinal Applications

edited by

Tsung-Rong Kuo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 995 | Submission Open

Keywords: nanotechnology; antibacterial; nanomaterials; toxicity; biocompatibility; medicinal applications

(This special issue belongs to the Section Molecular Nanoscience)

Toxicology Research: Understanding and Predicting Compound-Induced Toxicity

edited by

Miriam Beatríz Virgolini

submission deadline 30 Nov 2025 | 1 articles | Viewed by 956 | Submission Open

Keywords: toxicity; adverse-outcome pathway; metals; pesticides; drugs of abuse; pharmaceuticals

(This special issue belongs to the Section Molecular Toxicology)

Trace Elements, Metal Ions, Channels and Transporters in Metabolism

edited by

Maria Maares

submission deadline 30 Nov 2025 | 1 articles | Viewed by 953 | Submission Open

Keywords: cancer; cardiac dysfunction; enzyme function; metabolism; metal ions; neurologic disorders; pathophysiology; trace elements

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanoparticle-Based Biosensors and Their Applications

edited by

Edyta Proniewicz

submission deadline 30 Nov 2025 | 1 articles | Viewed by 952 | Submission Open

Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology

(This special issue belongs to the Section Molecular Nanoscience)

The Molecular and Cellular Pathophysiologic Mechanisms Underlying Ocular Diseases and Emerging Therapies (2nd Edition)

edited by

Snježana Kaštelan

submission deadline 30 Nov 2025 | 1 articles | Viewed by 900 | Submission Open

Keywords: eye disease; immunobiological features; molecular pathogenesis; biomarkers; clinical implications; emerging therapies; lacrimal gland; ocular tumors; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeting Epigenetic Complexes and Alternative Protein Degradation Pathways in Medicinal Chemistry

edited by Jean Leandro Dos Santos

submission deadline 30 Nov 2025 | 1 articles | Viewed by 872 | Submission Open

Keywords: protein degradation; LYTAC; AUTAC; ATTEC; epigenetics; NuRD; HDAC; BRD; SWI/SNF; PRC2; chromatin; conjugates; lysosome; autophagy; drug discovery

(This special issue belongs to the Section Biochemistry)

Intrinsically Disordered Proteins (IDPs): From Structure to Mechanism and Function

edited by

Kyouhoon Han

submission deadline 30 Nov 2025 | Viewed by 872 | Submission Open

Keywords: IDP; NMR; completely unstructured; pre-structured; PreSMo; target binding

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms in Mitochondria-Targeted Drug Delivery System

edited by

Maria Manuel Oliveira

and

Francisco Peixoto

submission deadline 30 Nov 2025 | Viewed by 828 | Submission Open

Keywords: mitochondria; mitochondrial diseases; nanoformulations; therapeutic agents; drug release; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Protein–Protein Interactions in Human Cancer

edited by

Geng Wu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 822 | Submission Open

Keywords: protein– protein interactions; protein– protein complexes; human cancer; signal transduction pathways; protein structure and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Environmental Pollutants Exposure and Toxicity

edited by

Tzveta Georgieva

submission deadline 30 Nov 2025 | 1 articles | Viewed by 820 | Submission Open

Keywords: environmental pollutants exposure assessment; molecular methods; biomarkers; human safety; environmental safety

(This special issue belongs to the Section Molecular Toxicology)

Analyzing the Molecular Mechanisms of Plant Disease Pathogenesis and Host Disease Resistance

edited by Zhibing Wu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 818 | Submission Open

Keywords: pathogenicity mechanisms; plant– pathogen interactions; plant immunity; effector biology; resistance genes; multi-omics approaches; nanotechnology in plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular View of Natural Products with Antiviral Effects

edited by

Jin-ching Lee

submission deadline 30 Nov 2025 | 1 articles | Viewed by 808 | Submission Open

Keywords: virus; phytochemicals; nutritional supplements; marine extracts; antioxidants

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 301-350 on page 7 of 70.

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