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The Latest Development of Molecular Research in Animal Nutrition

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Dear Colleagues,

This Special Issue is supervised by Dr. Mohammad Moniruzzaman and assisted by Dr. Md Mortuza Hossain.

We are pleased to invite you to contribute to this Special Issue entitled “The Latest Development of Molecular Research in Animal Nutrition” in the International Journal of Molecular Sciences. Recent advances in molecular biology and omics technologies have provided new insights into the intricate interactions between nutrients and gene expression, gut microbiota, metabolic regulation, and animal health. This research is revolutionizing the field of animal nutrition by enabling more precise, efficient, and sustainable feeding strategies.

This Special Issue aims to provide an advanced forum for original research and comprehensive reviews that delve into the molecular mechanisms underlying animal nutrition. In accordance with the International Journal of Molecular Sciences' emphasis on molecular biology, biochemistry, and molecular genetics, this collection will particularly highlight studies that employ innovative technologies (genomics, transcriptomics, proteomics, metabolomics) to reveal the complex biological processes associated with nutrient utilization, feed efficiency, and metabolic health in animals. Our aim is to present high-quality articles that showcase recent breakthroughs and foster a deeper, molecular-level understanding of animal health, welfare, and sustainable food production.

In this Special Issue, we look forward to presenting innovative research that enhances our understanding of molecular nutrition and contributes to the development of next-generation nutritional solutions for animal production and health.

Dr. Mohammad Moniruzzaman
Guest Editor

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Review

32 pages, 1863 KB

Open AccessReview

Gamma-Aminobutyric Acid (GABA) as a Dietary Strategy for Enhancing Temperature Stress Resilience in Aquaculture Species

by Abayomi Oladimeji Ogun, Mohammad Moniruzzaman, Hyuncheol Jeon, Haham Kim, Deni Aulia, Junhyeok Hur, Sooa Yoon, Suhyun Lee, Taesun Min and Seunghyung Lee

Int. J. Mol. Sci. 2025, 26(20), 10233; https://doi.org/10.3390/ijms262010233 - 21 Oct 2025

Viewed by 883

Abstract

The sustainability of aquaculture is increasingly threatened by rising ocean temperatures occasioned by the continued prevalence of global warming, which can have severe consequences for fish health and productivity. Fish, as ectothermic organisms, are susceptible to temperature fluctuations and prolonged exposure to extreme temperatures can lead to physiological disruptions, including altered metabolic rates, oxidative stress, and immune suppression, ultimately affecting their growth and reproductive success. In response, several strategies, including dietary supplementation, have been proposed to alleviate temperature stress in aquaculture. One such supplement, gamma (γ)-aminobutyric acid (GABA), a non-proteinogenic amino acid, has garnered attention for its potential to enhance stress resilience in aquatic species. In this review, we examine the physiological responses of fish to temperature stress and evaluate the role of GABA in alleviating non-temperature stress. By synthesizing the available evidence, we aim to highlight the potential of GABA as a dietary supplement to improve the resilience of farmed fish to temperature fluctuations, ultimately contributing to sustainable aquaculture in the face of climate change. GABA acts as an inhibitory neurotransmitter in the central nervous system, promoting relaxation and reducing stress. We not only spotlight GABA’s role in the central nervous system, where it has been shown to modulate stress responses by enhancing antioxidant defenses, improving growth performance, and boosting disease resistance, but also emphasize the limited exploration of its potential to mitigate temperature stress in some aquaculture species, particularly economically important fish like olive flounder. Finally, in this review, we provide additional insights into how GABA might help mitigate temperature stress by identifying factors that may influence its supplementation, thereby laying the groundwork for future research on its use as a potential tool for mitigating temperature stress in aquaculture species. Full article

(This article belongs to the Special Issue The Latest Development of Molecular Research in Animal Nutrition)

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