Steroids in Human Disease and Health
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 8
Special Issue Editor
Interests: steroids; steroidomics; chemometrics; neuroactive steroids; steroids and pregnancy; chromatography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Steroids regulate metabolism, immune response, and inflammation, playing a key role in health and disease. Dysregulation can contribute to conditions such as Cushing’s syndrome, Addison’s disease, and congenital adrenal hyperplasia. Corticosteroids, like cortisol, are widely used for autoimmune diseases, including rheumatoid arthritis and lupus, but prolonged use may lead to osteoporosis or adrenal insufficiency. Mineralocorticoids, like aldosterone, influence hypertension, heart failure, and kidney disease; excessive aldosterone is associated with primary aldosteronism, while deficiency leads to electrolyte imbalances. Immunoprotective androstanes modulate immune responses, aiding in the management of multiple sclerosis and inflammatory bowel diseases. Anabolic steroids, derived from testosterone, are used to treat muscle-wasting conditions but may lead to cardiac hypertrophy or mood disorders when misused. Neuroactive steroids, including allopregnanolone and pregnenolone, influence brain function and mood, holding therapeutic potential in depression, anxiety, and neurodegenerative disorders such as Alzheimer’s disease. Sex steroids, such as estrogens, progesterone, and testosterone, are crucial for reproductive health. Pregnancy steroids influence the stability of gestation, uterine growth, and fetal development.
This Special Issue, “Steroids in Human Disease and Health”, welcomes research on steroid functions, molecular mechanisms, and therapeutic applications, including high-throughput steroidomic approaches using advanced analytical platforms.
Potential topics include but are not limited to:
- Regulatory Roles of Steroids: Metabolic, Immune, and Inflammatory Pathways
- Evaluating Corticosteroids and Androstanes in Autoimmune Disorders: Therapeutic Potential and Risks
- Investigation of Neuroactive Steroids for Their Potential in Treating Depression, Anxiety, and Neurodegenerative Disorders
- Exploring Mineralocorticoids in Cardiovascular and Renal Disorders: Hypertension, Heart Failure, and Aldosteronism
- Exploring Steroid Dysregulation in Endocrine Disorders: Cushing’s Syndrome, Addison’s Disease, and Congenital Adrenal Hyperplasia
- Exploring Sex Steroids: Their Influence on Reproductive Health, Fetal Development, and Pregnancy
- The Impact of Anabolic Steroids on Heart Health and Mental Well-being
- High-Throughput Steroidomics: Innovations for Improved Accuracy and Clinical Utility
Dr. Martin Hill
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- steroid metabolism
- steroids and endocrinopathies
- steroids and inflammation
- corticosteroids
- mineralocorticoids
- neuroactive steroids
- steroids and neuropsychiatric diseases
- steroids and reproduction
- steroidomics
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