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Circulating Biomarkers for the Diagnosis of Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 418

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Guest Editor
Laboratório de Análises Clínicas, Centro Universitário FMABC, Santo André 09060-870, Brazil
Interests: liquid biopsy; breast cancer; neoplasia
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Special Issue Information

Dear Colleagues, 

Cancer is a disease with a high global impact and requires a broad approach for a conclusive and assertive diagnosis. Furthermore, cancer is an extremely challenging, multifactorial disease and, depending on the site and time of presentation, can be serious and fatal. Its mechanism of onset, as well as tumorigenesis, is a silent process that occurs beyond genetic mechanisms and involves a series of cellular events that can provide clues for its possible detection. Thus, in-depth study of detectable biomarkers in the development of cancer can be an important factor in survival and the maintenance of the patient's quality of life. In addition, biomarkers have the ability to classify individuals with the disease even before any sign of metastasis and impairment of general health is observed. Therefore, studying and expanding the application of circulating biomarkers in cancer is necessary. There is a lack of clinical studies and well-described and controlled trials that can identify possible circulating biomarkers in individuals with cancer. Depending on the overall goal, biomarkers can mainly be used to perform diagnosis and prognosis but can also be used for other applications. It is also necessary to develop laboratory methods that can be understood and applied in the clinic. Therefore, we invite authors to submit articles with unpublished results, reviews, and clinical and preclinical studies with the aim of addressing biomarkers that circulate in different cancers.

Dr. Fernando Luiz Affonso Fonseca
Guest Editor

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Keywords

  • biomarkers
  • circulating 
  • lab methods
  • diagnosis
  • screening

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Published Papers (1 paper)

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Research

10 pages, 258 KB  
Article
Expression Profile of IL-2, IL-6, IL-10, and TNF-α in Breast Tumors
by Harryson W. G. dos Santos, Beatriz C. Bramante, Matheus M. Perez, Glaucia L. da Veiga, Beatriz da C. A. Alves and Fernando L. A. Fonseca
Int. J. Mol. Sci. 2025, 26(16), 7841; https://doi.org/10.3390/ijms26167841 - 14 Aug 2025
Viewed by 335
Abstract
Chronic inflammation is associated with several neoplasms. Many studies tried to evaluate the correlation between cytokines and the pathogenesis of various cancer types and IL-2, IL-6, IL-10, and TNF-α are often target of these analyses. The aim of the present [...] Read more.
Chronic inflammation is associated with several neoplasms. Many studies tried to evaluate the correlation between cytokines and the pathogenesis of various cancer types and IL-2, IL-6, IL-10, and TNF-α are often target of these analyses. The aim of the present study was to analyze cytokines mRNA expression in breast cancer samples to better understand pathogenesis and clinical aspects. Patients were selected from the oncology service of Centro Universitário FMABC; tumor RNA was obtained from formalin-fixed paraffin-embedded biopsies of breast cancer tissue. Gene expression was assessed by qPCR. Samples from 95 patients were obtained, presenting tumor stages varying from 0 to IIIB, with most of them in stage IIIA (33.68%). IL-2 and TNF-α expression presented a significant correlation with tumor stage. There was no correlation of cytokines expression with Ki-67 and prognostic factors. The study illustrated the pleiotropic role of IL-2, with no expression in early stages of cancer, varying according to “stage worsening”. Regarding progesterone receptor (PR), correlation with TNF-α and IL-2 can reinforce the role of PR as an indicator of positive prognosis. The findings of this investigation suggest IL-2 and TNF-α could be evaluated in a larger study to better understanding pathogenesis and prognosis for this patient profile. Full article
(This article belongs to the Special Issue Circulating Biomarkers for the Diagnosis of Cancer)
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