ijms-logo

Journal Browser

Journal Browser

Toxicology Research: Understanding and Predicting Compound-Induced Toxicity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 32

Special Issue Editor


E-Mail Website
Guest Editor
Departamento de Farmacología Otto Orsingher, Instituto de Farmacología Experimental de Córdoba-Consejo Nacional de Investigaciones Técnicas (IFEC-CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
Interests: neurotoxicology; caenorhabditis elegans; metals; pesticides; drugs of abuse

Special Issue Information

Dear Colleagues,

Mechanistic toxicology has evolved into a more integrative vision, moving beyond isolated molecular or cellular events to a broader understanding of toxicity across biological levels in accordance with a systems perspective. The framework involving adverse-outcome pathways plays a central role in this shift, offering a sequentially organized level of biological associations, with a molecular initiating event triggering a series of key events and an observable adverse outcome at the individual or population level.

This framework supports the advancement of next-generation risk assessment and new approach methodologies, which include in silico, in vitro, and non-mammalian in vivo tools. Together, these approaches aim to improve toxicity testing, enabling the identification of early and key effect biomarkers for the better protection of human health.

In this Special Issue, we aim to highlight recent progress in the application of adverse-outcome pathway to predictive toxicology, emphasizing mechanistic insight and innovation across emerging and traditional toxicological platforms.

Suitable topics include, but are not limited to, the following areas:

  • Toxicology;
  • Pharmacology;
  • Toxicological risk assessment;
  • Mechanisms of toxicity

Prof. Dr. Miriam Beatríz Virgolini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • toxicity
  • adverse-outcome pathway
  • metals
  • pesticides
  • drugs of abuse
  • pharmaceuticals

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers

This special issue is now open for submission.
Back to TopTop