Exploring the Cytoskeleton and Its Regulators: From Structure to Function
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 2423
Special Issue Editor
2. Channelopathy Research Center (CRC), Dongguk University School of Medicine, Ilsan 10326, Republic of Korea
Interests: mechanotransduction; cytoskeleton remodeling; proliferation; differentiation; myogenesis; sarcopenia; insulin resistance; diabetes; metabolism; glucose metabolism; lipid metabolism; metabolic diseases; energy metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cytoskeleton stands at the forefront of cellular organization, essential not only for maintaining structure but also for facilitating complex functions across cellular biology. It is a dynamic matrix that orchestrates numerous processes, such as mechanosensing, motility, adhesion, and signaling pathways. This matrix is intricately regulated by cytoskeleton-binding proteins (CBPs), which serve as crucial modulators of cytoskeletal behavior, interpreting mechanical stimuli into actionable biochemical signals that dictate cellular fate and behavior.
The cytoskeleton’s integral role in cell mechanics extends beyond static structural support; it actively participates in signaling networks that regulate cellular responses to environmental cues, impacting critical processes like proliferation, migration, differentiation, and survival. This dynamic involvement underscores the cytoskeleton’s pivotal role in understanding cellular behavior in physiological and pathological contexts.
Despite recent progress in the field, significant gaps remain in our understanding of how the cytoskeleton and CBPs coordinate and control the complex signaling pathways that influence cell behavior under different physiological and pathological states. This Special Issue seeks to bridge these gaps by gathering the latest research and comprehensive analyses that advance our understanding of the structural and functional roles of the cytoskeleton and its regulatory proteins.
This Special Issue aims to delve into the latest research and developments in cytoskeleton and CBP studies. We invite submissions of original research articles and comprehensive review papers that provide new insights into the structure, regulation, and function of the cytoskeleton and its associated proteins. Topics of interest include, but are not limited to, the following:
- Mechanosensing and Mechanotransduction: Understanding how cells sense and respond to mechanical stimuli through cytoskeletal changes.
- Cellular Motility and Migration: Investigating the mechanisms by which cytoskeletal components facilitate cell movement and tissue organization.
- Signal Transduction Pathways: Exploring the biochemical pathways mediated by cytoskeletal elements and their impact on cellular decision-making.
- Structural Analysis: Advanced imaging and molecular studies revealing the architecture of cytoskeletal networks.
- The Cytoskeleton in Disease: Examining how alterations in cytoskeletal dynamics contribute to disease processes, including cancer, neurodegenerative disorders, and inflammatory responses.
- Therapeutic Targets: Evaluating CBPs as potential therapeutic targets for modulating cellular behavior in disease treatment and prevention.
By gathering the latest findings in this field, we aim to provide a platform for the dissemination of knowledge that will foster further research and collaboration.
Prof. Dr. Wan Lee
Guest Editor
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Keywords
- cytoskeleton
- cytoskeleton-binding protein
- cytoskeletal protein
- cell signaling
- mechanotransduction
- cell proliferation
- cell migration
- cellular motility
- cell differentiation
- structural biology
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