Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 867
Special Issue Editor
Interests: molecular mechanisms that regulate metabolic reprogramming in cancer cells in response to different types of stress and potential therapeutic implications of inhibiting their function; AMPK-related kinases, mTOR complexes; Ras GTPases signaling in cancer
Special Issue Information
Dear Colleagues,
Unraveling the molecular mechanisms of cancer remains a significant challenge in biomedical research. The discovery of oncogenes and tumor suppressors closed gaps in our understanding of the biology of the cancer cell. These genes serve as critical nodes in complex networks that impact many cell features, such as cell growth and survival, immune responses, metabolic adaptation, and resistance to therapy. However, ongoing research continues to explore the multifaceted biology of oncogenes and tumor suppressors, from their discovery and mechanistic insights to their implications in cancer diagnosis, prognosis, and treatment. As research advances, the connections between basic discoveries and clinical applications grow stronger, paving the way for breakthroughs that could change the cancer treatment landscape. This Special Issue invites contributions that explore oncogenes and tumor suppressors from multiple angles, such as their fundamental biology, interactions with the microenvironment, and relevance as therapeutic targets or biomarkers.
Prof. Dr. Ariel Fernando Castro
Guest Editor
Manuscript Submission Information
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Keywords
- oncogenes
- tumor suppressors
- cancer biology
- molecular mechanisms
- tumor microenvironment
- biomarkers
- targeted cancer therapy
- cancer initiation and progression
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