Non-Coding RNAs’ Functionality—Diagnosis and Therapy in Cancer and Other Indications (2nd Edition)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 38
Special Issue Editor
Interests: molecular biology; genetic and protein engineering; noncoding RNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Only a small fraction of transcribed RNAs are translated to proteins and involved in the central dogma. The overwhelming majority of transcribed RNA is not translated to protein and is thus termed non-coding RNA. However, this does not mean that transcribed non-coding RNAs do not have important cellular functions. Research has indicated multiple functions for non-coding RNA, which include it having epigenetic effects on other coding mRNAs and regulating multiple cellular functions, such as protein expression and localization, cell proliferation, cancer, cell apoptotic death, the cell cycle, cell migration and invasiveness, epithelial–mesenchymal transition (EMT), cancer stem cells, and drug resistance in cancer.
In this Special Issue, we will focus on the vital functional roles of the main types of non-coding RNAs expressed in cancer, as well as the state of the art, to monitor their aberrational expression in cancer diagnoses and their therapeutic potential.
Volume I of this Special Issue: “Non-coding RNAs' Functionality-Diagnosis and Therapy in Cancer and Other Indications”
Prof. Dr. Mohamed Raafat El-Gewely
Guest Editor
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Keywords
- non-coding RNAs (ncRNAs)
- long non-coding RNAs (lncRNAs)
- MicroRNAs (miRNAs)
- circular RNAs (circRNAs)
- epigenetic and post-transcriptional regulation
- epithelial–mesenchymal transition (EMT)
- cell proliferation and Apoptosis
- biomarkers and Liquid biopsy
- RNA-based therapeutics
- next-generation sequencing (NGS)
- CRISPR/Cas9 screening
- single-cell RNA sequencing (scRNA-seq)
- RNA interference (RNAi)
- cancer stem cells
- early cancer diagnosis
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