Trace Elements, Metal Ions, Channels and Transporters in Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 1847
Special Issue Editor
Special Issue Information
Dear Colleagues,
Trace elements, including zinc (Zn2+), copper (Cu+, Cu2+), chromium (Cr3+), selenium (Se), manganese (Mn2+), molybdenum (Mo2+) and cobalt (Co3+), and macro elements such as calcium (Ca2+), magnesium (Mg2+), sodium (Na+) and potassium (K+), are key regulators of enzymes and their activities due to their frequent function as enzymatic co-factors. Due to their important role in regulating enzymatic functions, their dysregulation on the organismal and especially (sub-) cellular level is frequently associated with severe pathologies, including neuronal-, cardiac- and hepatobiliary disorders, or even cancer development or progression. In particular, ion channels and transporters located within the cellular plasma membrane or in the membranes of subcellular organelles seem to play a key role in these processes.
Approaches to understanding the physiologic role and methods to investigate these elements with high spatial and temporal resolution are, hence, of utmost importance and are highly desired. Therefore, several approaches to detect concentrations and alterations of these elements including (fluorescent) sensors, biochemical- and chemical approaches, have been developed in the past, allowing us to correlate trace element and metal ion concentrations and homeostasis with cell metabolic activities.
Within this Special Issue, we aim to highlight new findings of metabolic regulation pathways via trace elements and other metal ions, and thereto related topics, which will contribute to our understanding of the molecular causes of several diseases.
Dr. Maria Maares
Guest Editor
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Keywords
- cancer
- cardiac dysfunction
- enzyme function
- metabolism
- metal ions
- neurologic disorders
- pathophysiology
- trace elements
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