Structural Codes of Sphingolipids and Their Involvement in Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 23
Special Issue Editors
Interests: gangliosides; Parkinson’s disease; mebrane organization; complex lipids; sphingosine; ceramide
Special Issues, Collections and Topics in MDPI journals
Interests: glycosphingolipids; gangliosides; GM1; GM1 oligosaccharide; plasma membrane signaling; neuronal disease; Parkinson’s disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sphingolipids are complex membrane components and are characterized by a great diversity of their structure. They show a wide range of amphiphilic characters, ranging from very hydrophobic to very hydrophilic molecules. Both of the two moieties, the hydrophobic tail and the hydrophilic head, are recognized by specific protein sequences of amino acids that allow the formation of sphingolipid-protein complexes necessary for metabolic processes instrumental for the correct life of cells. The structural diversity of sphingolipids allows the formation of multiple sphingolipid-protein complexes instrumental for a variety of cellular processes. Derailment from the correct synthesis or catabolism of sphingolipids leads to an altered membrane composition followed by incorrect or impossible interaction processes between sphingolipids and proteins, lipid transporters, or membrane receptors. As a result, an altered physiology of the cell follows with the onset of serious diseases.
Contributions to this Special Issue should focus on the latest advances in sphingolipid biophysics, biochemistry, and cell and molecular biology instrumental for the understanding of some aspects of neuronal development, cancer, host–pathogen interactions, and, with a special emphasis on how these molecules disease and neurodegeneration.
Prof. Dr. Sandro Sonnino
Dr. Elena Chiricozzi
Guest Editors
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Keywords
- sphingolipids
- sphingolipid hydrophilic head
- sphingolipid hydrophobic tail
- sphingolipid signalling
- sphingolipid diseases
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