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Translational Oncology: From Molecular Basis to Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 518

Special Issue Editors


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Guest Editor
Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy
Interests: translational oncology; resistance to therapy; secretome signaling; microRNAs; cell transformation; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy
Interests: senescence and cancer; tumor microenvironment; therapy resistance; cancer genomics; epigenomics

Special Issue Information

Dear Colleagues, 

The field of Translational Oncology is rapidly expanding owing to the increasing availability of molecular targets in tumors and targeted compounds. With the merging of multi-omics, including genomics, proteomics, metabolomics, and glycomics, we are gaining a deeper understanding of the adaptive dynamics of tumors, beyond what single genomics can offer. Additionally, novel models such as 3D growing spheroids, organoids, and microfluidic-based cultures are now available, and these are of higher clinical relevance. It is crucial that we obtain a comprehensive understanding of tumor biology that encompasses all of these aspects to fully comprehend the complexity of cancer. This understanding is of the upmost priority and promises to provide novel tools that attenuate cancer progression and resistance to therapy. We kindly invite you to join us in discussing all of these important aspects of this topic.

Dr. Mario Cioce
Dr. Gatti Veronica
Guest Editors

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Keywords

  • cancer
  • therapy resistance
  • translational oncology
  • cancer stem cells
  • immunotherapy
  • cancer metabolism
  • OMICS
  • patient-derived-organoids
  • drug repositioning
  • TKI

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Published Papers (1 paper)

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Review

17 pages, 1590 KiB  
Review
Molecular Mechanisms of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma
by Taketo Kato, Ichidai Tanaka, Heng Huang, Shoji Okado, Yoshito Imamura, Yuji Nomata, Hirofumi Takenaka, Hiroki Watanabe, Yuta Kawasumi, Keita Nakanishi, Yuka Kadomatsu, Harushi Ueno, Shota Nakamura, Tetsuya Mizuno and Toyofumi Fengshi Chen-Yoshikawa
Int. J. Mol. Sci. 2025, 26(9), 4299; https://doi.org/10.3390/ijms26094299 - 1 May 2025
Abstract
Mesothelioma is characterized by the inactivation of tumor suppressor genes, with frequent mutations in neurofibromin 2 (NF2), BRCA1-associated protein 1 (BAP1), and cyclin-dependent kinase inhibitor 2A (CDKN2A). These mutations lead to disruptions in the Hippo signaling pathway [...] Read more.
Mesothelioma is characterized by the inactivation of tumor suppressor genes, with frequent mutations in neurofibromin 2 (NF2), BRCA1-associated protein 1 (BAP1), and cyclin-dependent kinase inhibitor 2A (CDKN2A). These mutations lead to disruptions in the Hippo signaling pathway and histone methylation, thereby promoting tumor growth. NF2 mutations result in Merlin deficiency, leading to uncontrolled cell proliferation, whereas BAP1 mutations impair chromatin remodeling and hinder DNA damage repair. Emerging molecular targets in mesothelioma include mesothelin (MSLN), oxytocin receptor (OXTR), protein arginine methyltransferase (PRMT5), and carbohydrate sulfotransferase 4 (CHST4). MSLN-based therapies, such as antibody–drug conjugates and immunotoxins, have shown efficacy in clinical trials. OXTR, upregulated in mesothelioma, is correlated with poor prognosis and represents a novel therapeutic target. PRMT5 inhibition is being explored in tumors with MTAP deletions, commonly co-occurring with CDKN2A loss. CHST4 expression is associated with improved prognosis, potentially influencing tumor immunity. Immune checkpoint inhibitors targeting PD-1/PD-L1 have shown promise in some cases; however, resistance mechanisms remain a challenge. Advances in multi-omics approaches have improved our understanding of mesothelioma pathogenesis. Future research will aim to identify novel therapeutic targets and personalized treatment strategies, particularly in the context of epigenetic therapy and combination immunotherapy. Full article
(This article belongs to the Special Issue Translational Oncology: From Molecular Basis to Therapy)
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