Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 354
Special Issue Editor
Interests: cGMP; signaling proteins; signal transduction pathways; kinases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular and tissue signaling by cyclic nucleotides (cNMP, e.g., cAMP, and cGMP) is an expanding field that comprises molecular functions and (patho)physiology in various organ systems. Cyclic nucleotide synthesis, degradation, and function are modulated by a variety of signaling proteins and signal transduction pathways. Stuctural, biochemical, and (patho)physiological aspects have been greatly elucidated in the last decade in relation to cardiovascular, immunological, renal, pulmonary, gastrointestinal, and neuronal functions. The dysregulation of cyclic nucleotide generators (e.g., adenylyl/guanylyl cyclases), modulators (phosphodiesterases), and signaling molecules (e.g., kinases/substrates, channels) has been identified as the cause of pathophysiological processes and diseases. Pharmacological approaches have been utilized in pharmacological treatments for conditions including hypertension and cardiovascular and gastrointestinal diseases. Therefore, a molecular and functional understanding of diverse cyclic nucleotide generators, signaling proteins, scaffolds, and signal transduction pathways is fundamental in gaining an insight into their (patho)physiological processes. Futhermore, the non-canonical cyclic nucleotides (e.g., cCMP and cUMP) and the cyclic dinucleotides (e.g., cGAMP) are currently attracting interest. The aim for this Special Issue is to summarize and enhance the knowledge of these signaling processes and networks in diverse cells/tissues and to link it to (patho)physiological and pharmacological functions.
Therefore, authors are invited to submit original research and review articles that address the progress made and the current state of the art in cyclic nucleotide signaling.
Posible topics include, but are not limited to, the following:
- Identification and new molecular and functional aspects of cyclic nucleotide signaling molecules and pathways;
- Analysis of cyclic nucleotide signal generation, modulation, recognition, and/or transduction into (patho)physiological responses and/or pharmacologcal approaches;
- Techniques for the analysis and identification of cyclic nucleotide signaling molecules, scaffolds, pathways, and networks.
Dr. Jens Schlossmann
Guest Editor
Manuscript Submission Information
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Keywords
- cyclic nucleotide
- cNMP, cAMP, cGMP, cCMP, cUMP, cGAMP
- signaling proteins
- signal transduction pathways
- scaffolds
- nitric oxide
- natriuretic peptides
- adenylyl cyclases, guanylyl cyclases
- kinases
- phosphodiesterases
- channels
- (patho)physiology
- pharmacology
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