Enhancing Stem Cell Grafting in Tissue Regeneration and Repair
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 11
Special Issue Editor
Interests: stem cells; exosomes; gene therapy; tissue engineering; 3D organoids; biomaterials; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue will focus on the pivotal role of stem cell therapy in improving the outcomes of tissue regeneration and repair, specifically through enhanced grafting strategies. We invite submissions that delve into the molecular and cellular mechanisms underpinning successful and unsuccessful stem cell engraftment, with the goal of identifying novel approaches to optimize therapeutic efficacy.
We are particularly interested in research that addresses challenges and breakthroughs in improving previously performed grafts. This includes studies exploring the following:
- Strategies to enhance stem cell survival, integration, and function within host tissues post-transplantation. This could involve investigations into specific growth factors (e.g., PEDF, BDNF), signaling pathways (e.g., PI3K/Akt/mTOR, PPAR-alpha, and Wnt), and extracellular vesicles (e.g., exosomes) that influence engraftment success.
- Novel approaches to overcome barriers to successful grafting, such as immune rejection, poor vascularization, and insufficient cell retention.
- The application of diverse stem cell types (e.g., induced pluripotent stem cells (iPSCs), mesenchymal stem cells, body fluid-derived stem cells like urine-derived stem cells, and tissue-specific stem cells such as limbal stem cells) in improving graft outcomes in various organs (e.g., the cornea, kidney, and urogenital system).
- Preclinical and translational studies that provide insights into enhancing the therapeutic potential of stem cells through genetic modification, biomaterial scaffolds, and advanced culture techniques, with a direct focus on graft improvement.
- Analyses of factors contributing to both successful and unsuccessful graft outcomes in previous clinical or preclinical studies, aiming to extract lessons for future advancements.
Ultimately, this Special Issue seeks to highlight targeted molecular and cellular strategies for optimizing stem cell engraftment, thereby advancing the field of tissue regeneration and repair by building upon existing knowledge of graft performance.
Dr. Yuanyuan Zhang
Guest Editor
Manuscript Submission Information
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Keywords
- stem cell therapy
- tissue regeneration
- graft enhancement
- molecular mechanisms
- engraftment
- biomaterials
- immunomodulation
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