Pancreatic Disease: From Molecular Basis to Novel Therapies—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 674
Special Issue Editor
Interests: transcription factors; Krüppel-like factor 4 (KLF4); Krüppel-Like Factor 5 (KLF5); intestinal biology; injury; inflammation; pancreatic neoplasia; pancreatic cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue titled “Pancreatic Disease: From Molecular Basis to Novel Therapies”. The pancreas, with its exocrine and endocrine functions, sits at the intersection of the body’s digestive and endocrine systems. Pancreatic acinar and ductal cells act in concordance to synthesize, store, and release digestive enzymes into pancreatic ducts, which drain into the duodenum. Pancreatic endocrine glands, called islets of Langerhans, regulate blood sugar levels by secreting two hormones into the blood: insulin and glucagon. The physiology of the pancreas is very tightly controlled, and disruptions result in pancreatitis (acute and chronic), pancreatic cancer, and Diabetes Mellitus (type 1 and 2). Several known perturbations induce acute pancreatitis, including the overactivation of trypsinogen, increased inflammatory cell infiltration, and the destruction of secretory cells. Recently, mitochondrial, lysosomal, and autophagic dysfunction, as well as calcium overload and increased endoplasmic reticulum stress, have been identified as drivers of pancreatitis progression. Chronic injury is characterized by fibro-inflammatory pathophysiology leading to the destruction of the pancreatic parenchyma. This is caused by genetic and environmental factors that are exacerbated by alcohol, nicotine, nutritional, and metabolic factors, to name a few. It has been shown that obesity, smoking, chronic pancreatitis, bacterial infections, and diabetes are the primary risk factors for pancreatic cancer development. Diabetes Mellitus is characterized by impaired sugar, protein, and fat metabolism resulting from insulin deficiency. Managing pancreatic diseases has yet to be very successful. Thus, novel interventions are required that can necessitate a better understanding of the mechanisms underlying the development of pancreatic pathologies. This Special Issue highlights recent progress in understanding the physiology and pathophysiology of the pancreas and therapeutic developments.
Dr. Agnieszka B. Bialkowska
Guest Editor
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Keywords
- pancreatitis
- acinar-to-ductal neoplasia
- early pancreatic neoplasia
- fibroinflammatory disease
- pancreatic cancer
- diabetes Mellitus
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