Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Aquaporins at the Crossroads of Human Health and Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 100 | Submission Open
Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
Role of Oxidative Stress in Cardiovascular Diseases submission deadline 31 Jan 2026 | Viewed by 52 | Submission Open
Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in the Role of Lipid Signaling in Diseases
edited by and
submission deadline 5 Feb 2026 | Viewed by 138 | Submission Open
Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation
Role of Alpha-Synuclein in Neurodegenerative Diseases
edited by
submission deadline 10 Feb 2026 | 1 articles | Viewed by 1069 | Submission Open
Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases
(This special issue belongs to the Section Cellular Aging)
Decoding Cellular Organization Through Spatial Omics
edited by Elizabeth Neumann
submission deadline 10 Feb 2026 | Viewed by 111 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Exclusive Review Papers in Autophagy—Second Edition
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 16138 | Submission Open
Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades
(This special issue belongs to the Section Autophagy)
Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 12871 | Submission Open
Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 8309 | Submission Open
Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Molecular Therapeutic Advances for Neurodegenerative Diseases
edited by
submission deadline 15 Feb 2026 | 3 articles | Viewed by 4561 | Submission Open
Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders
(This special issue belongs to the Section Cellular Aging)
Spotlight on Natural Killer Cells in Immuno-Oncology submission deadline 15 Feb 2026 | 1 articles | Viewed by 3220 | Submission Open
Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Mechanisms of Tumorigenesis
edited by
submission deadline 15 Feb 2026 | 1 articles | Viewed by 1493 | Submission Open
Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine
Placenta in Tissue Engineering and Regeneration
edited by
submission deadline 15 Feb 2026 | Viewed by 148 | Submission Open
Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration
Cancers and Metabolic Diseases—the Molecular Players in the Game
edited by
submission deadline 15 Feb 2026 | Viewed by 95 | Submission Open
Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics
GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma
edited by
submission deadline 15 Feb 2026 | Viewed by 86 | Submission Open
Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors
Cellular Mechanisms and Therapies of Hematologic Malignancies
edited by Sayantani Sinha and Stanley Chun-Wei Lee
submission deadline 15 Feb 2026 | Viewed by 75 | Submission Open
Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance
(This special issue belongs to the Section Cellular Pathology)
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease
edited by , , Michy P. Kelly and Leila Gobejishvili
submission deadline 20 Feb 2026 | 16 articles | Viewed by 39830 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications
edited by and Elisabetta Zucchi
submission deadline 20 Feb 2026 | 5 articles | Viewed by 9443 | Submission Open
Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy
(This special issue belongs to the Section Cells of the Nervous System)
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Feb 2026 | 3 articles | Viewed by 6112 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3566 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
T Cells in Inflammation and Cancer
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2416 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
The Cell Biology of Heart Disease
edited by Rajeshwary Ghosh and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1439 | Submission Open
Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure
(This special issue belongs to the Section Cells of the Cardiovascular System)
Role of Gene Regulation in Neurological Disorders
edited by and Yulin Jin
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1427 | Submission Open
Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)
(This special issue belongs to the Section Cell and Gene Therapy)
Molecular Mechanisms of Leukemias
edited by and Frode Selheim
submission deadline 20 Feb 2026 | 1 articles | Viewed by 893 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)
(This special issue belongs to the Section Cellular Pathology)
Current Advances in Plant Gene Regulatory Networks submission deadline 20 Feb 2026 | 1 articles | Viewed by 870 | Submission Open
Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Advances in Molecular Research on Cancer Drug Targets and Drug Resistance
edited by , and
submission deadline 20 Feb 2026 | Viewed by 201 | Submission Open
Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers
Molecular Cell Biology of T Cells in Cancer and Infectious Diseases
edited by and João Viola
submission deadline 20 Feb 2026 | Viewed by 144 | Submission Open
Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism
(This special issue belongs to the Section Cellular Immunology)
Elucidating Roles of Cell Adhesion Molecules in Health and Disease
edited by Vladimir Sytnyk
submission deadline 20 Feb 2026 | Viewed by 128 | Submission Open
Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs(IgSF-CAMs); integrins; cadherins; selectins; proteoglycans
Advances in T Cell Targeting for Cancer Immunotherapy
edited by Ryma Toumi
submission deadline 20 Feb 2026 | Viewed by 90 | Submission Open
Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy
Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications submission deadline 20 Feb 2026 | Viewed by 72 | Submission Open
Keywords: autophagy; pathology; physiology; therapy; methods
(This special issue belongs to the Section Autophagy)
Astrocytes: Roles and Functions in the Brain submission deadline 21 Feb 2026 | Viewed by 89 | Submission Open
Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting
Natural Products and Their Derivatives Against Human Disease
edited by
submission deadline 25 Feb 2026 | 6 articles | Viewed by 10037 | Submission Open
Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment
edited by
submission deadline 25 Feb 2026 | 1 articles | Viewed by 576 | Submission Open
Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease
Small Molecule Inhibitors: A New Era in Cancer Treatment
edited by , and Suman Asalla
submission deadline 25 Feb 2026 | Viewed by 174 | Submission Open
Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance
Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs submission deadline 25 Feb 2026 | Viewed by 132 | Submission Open
Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds
Research on Extracellular Vesicles in Health and Disease submission deadline 25 Feb 2026 | Viewed by 129 | Submission Open
Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA
Molecular and Cellular Mechanisms of Ischemic Stroke
edited by Milani Deb-Chatterji
submission deadline 25 Feb 2026 | Viewed by 111 | Submission Open
Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy
New Trends and Advances in Induced Neural Cells and iPSC Technologies
edited by
submission deadline 25 Feb 2026 | Viewed by 106 | Submission Open
Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling
(This special issue belongs to the Section Cells of the Nervous System)
Remyelination: From Molecular Mechanism to Therapy submission deadline 25 Feb 2026 | Viewed by 104 | Submission Open
Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration
Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives
edited by Peter Van Endert
submission deadline 25 Feb 2026 | Viewed by 95 | Submission Open
Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy
Molecular Mechanisms of Treatment Resistance in Prostate Cancer
edited by
submission deadline 25 Feb 2026 | Viewed by 79 | Submission Open
Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance
The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease submission deadline 26 Feb 2026 | Viewed by 70 | Submission Open
Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling
(This special issue belongs to the Section Tissues and Organs)
Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders
edited by Mohamed Eldeeb
submission deadline 27 Feb 2026 | 1 articles | Viewed by 1340 | Submission Open
Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration
(This special issue belongs to the Section Mitochondria)
Novel Insights into Mechanism and Treatment of Degenerative Disc Disease
edited by Yejia Zhang
submission deadline 27 Feb 2026 | 1 articles | Viewed by 1102 | Submission Open
Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury
(This special issue belongs to the Section Cellular Pathology)
Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation
edited by Hari Krishna Reddy Rachamala and
submission deadline 27 Feb 2026 | 1 articles | Viewed by 114 | Submission Open
Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology
(This special issue belongs to the Section Cell Methods)
Targeting of Cancer Cells with Small Molecule Drugs
edited by
submission deadline 27 Feb 2026 | Viewed by 79 | Submission Open
Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology
(This special issue belongs to the Section Cellular Pathology)
Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets
edited by Saverio Gentile
submission deadline 27 Feb 2026 | Viewed by 66 | Submission Open
Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment
Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies
edited by Kyle Lauren Poulsen
submission deadline 27 Feb 2026 | Viewed by 66 | Submission Open
Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics
Signaling in Cancer Stem Cells
edited by Upasana Ray
submission deadline 28 Feb 2026 | 3 articles | Viewed by 11700 | Submission Open
Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs
(This special issue belongs to the Section Stem Cells)
Role of Extracellular Matrix in Cancer and Disease submission deadline 28 Feb 2026 | 6 articles | Viewed by 10428 | Submission Open
Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling
(This special issue belongs to the Section Cell Microenvironment)
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