Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Immune Responsiveness in the Era of T Cell Immunotherapy
edited by and
submission deadline 15 Aug 2026 | 2 articles | Viewed by 2775 | Submission Open
Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation
Plant Stress and Acclimation Responses During Global Warming submission deadline 15 Aug 2026 | 1 articles | Viewed by 1630 | Submission Open
Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Genetics and Gene Regulation
edited by and
submission deadline 15 Aug 2026 | 1 articles | Viewed by 1452 | Submission Open
Keywords: genetics; gene regulation; human diseases
Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread
edited by Erica Pranzini
submission deadline 15 Aug 2026 | Viewed by 330 | Submission Open
Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism
Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches
edited by
submission deadline 15 Aug 2026 | Viewed by 268 | Submission Open
Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics
(This special issue belongs to the Section Stem Cells)
Advances in Osteosarcoma: Tumor Biology and Therapeutic Innovation submission deadline 15 Aug 2026 | Viewed by 242 | Submission Open
Keywords: osteosarcoma; immunotherapy; biomarker
(This special issue belongs to the Section Cellular Pathology)
Cellular Immunotherapies and Immune Modulation in Hematologic Cancers
edited by Erden Atilla and Ali Turan
submission deadline 15 Aug 2026 | Viewed by 171 | Submission Open
Keywords: cellular immunotherapy; CAR T; CAR NK; immune modulation; hematologic malignancies; microenvironment; cytokine biology; immune escape
(This special issue belongs to the Section Cellular Immunology)
Multipotent Mesenchymal Stromal Cells in the Tumor Microenvironment: Recent Advances and Emerging Concepts
edited by Yuri Petrenko
submission deadline 15 Aug 2026 | Viewed by 161 | Submission Open
Keywords: multipotent mesenchymal stromal cells; tumor microenvironment; cancer stem cells; metabolic rewiring; biomechanical cues; 3D modelling; paracrine interactions; vascularization; differentiation
(This special issue belongs to the Section Stem Cells)
Multi-Omics in the Cellular Microenvironment
edited by Emilio S. Rivera and Katerina Djambazova
submission deadline 15 Aug 2026 | Viewed by 149 | Submission Open
Keywords: cellular microenvironment; single-cell analysis; multi-omics; immunofluorescence microscopy; imaging mass spectrometry
(This special issue belongs to the Section Cell Methods)
Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment
edited by
submission deadline 18 Aug 2026 | 2 articles | Viewed by 5932 | Submission Open
Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Aug 2026 | 3 articles | Viewed by 11815 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
Ageing and Neurodegenerative Diseases, Second Edition
edited by Feng Wang and
submission deadline 20 Aug 2026 | 3 articles | Viewed by 11331 | Submission Open
Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling
(This special issue belongs to the Section Cellular Pathology)
Role of Gene Regulation in Neurological Disorders
edited by and Yulin Jin
submission deadline 20 Aug 2026 | 3 articles | Viewed by 4488 | Submission Open
Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)
(This special issue belongs to the Section Cell and Gene Therapy)
Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition
edited by and
submission deadline 20 Aug 2026 | 1 articles | Viewed by 3632 | Submission Open
Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction
(This special issue belongs to the Section Cellular Pathology)
Advances in Molecular Research on Cancer Drug Targets and Drug Resistance
edited by , and Rakesh Kumar Srivastava
submission deadline 20 Aug 2026 | 3 articles | Viewed by 3112 | Submission Open
Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers
Small-Molecule Approaches to Counteract Demyelination and Neurodegeneration
edited by David Lutz
submission deadline 20 Aug 2026 | 2 articles | Viewed by 1933 | Submission Open
Keywords: demyelination; neurorepair; small-molecule therapeutics; neurodegeneration
(This special issue belongs to the Section Cellular Neuroscience)
Autophagy-Related Proteins in Stress Responses submission deadline 20 Aug 2026 | 1 articles | Viewed by 854 | Submission Open
Keywords: stress response; ATG; endocytosis; exocytosis; autophagy
(This special issue belongs to the Section Autophagy)
Mesenchymal Stem Cells in Cell Therapy, Regenerative Medicine, and Tissue Engineering
edited by and
submission deadline 20 Aug 2026 | 1 articles | Viewed by 453 | Submission Open
Keywords: mesenchymal stem cells (MSCs); tissue engineering and scaffolds; regenerative medicine; cell-based therapies; differentiation and immunomodulation
(This special issue belongs to the Section Stem Cells)
Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
edited by and Benjamin Wolozin
submission deadline 20 Aug 2026 | Viewed by 316 | Submission Open
Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Pathological Mechanisms and Therapeutic Strategies of Alzheimer’s Disease
edited by Boris DeCourt, Travis Thompson and
submission deadline 20 Aug 2026 | Viewed by 281 | Submission Open
Keywords: Alzheimer’ s disease; amyloid beta; biomarkers; gut-brain axis; mechanisms; neurotransmitter imbalance; pathology; tau; treatments
(This special issue belongs to the Section Cellular Aging)
The Circulating Tumor Microenvironment (cTME): Emerging Taxonomies and Multimodal Landscapes
edited by
submission deadline 20 Aug 2026 | Viewed by 164 | Submission Open
Keywords: circulating tumor microenvironment (cTME); circulating tumor-associated cells (C-TACs); circulating tumor emboli (CTE); extracellular vesicles; metastatic cascade; experimental cytology; functional assays; precision oncology; liquid biopsy; next-generation sequencing (NGS)
(This special issue belongs to the Section Cell Microenvironment)
Metabolic, Signaling, and Transcriptomic Regulation of NK Cell Development and Functions submission deadline 20 Aug 2026 | Viewed by 152 | Submission Open
Keywords: NK cells; immunometabolism; mTOR; AMPK; JAK– STAT; checkpoint signaling; transcription factors; enhancers; epigenetics; chromatin accessibility; single-cell multi-omics; spatial transcriptomics; tumor microenvironment; immunotherapy; transplantation
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Insights into Age-Related Macular Degeneration submission deadline 20 Aug 2026 | Viewed by 130 | Submission Open
Keywords: age-related macular degeneration (AMD); lipid metabolism/lipid dysregulation; retinal pigment epithelium (RPE); photoreceptors; complement system/complement dysregulation; neurodegeneration; retinal degeneration
(This special issue belongs to the Section Cellular Aging)
The Cerebellum: New Neurons, Circuits and Functions
edited by and Jinsook Kim
submission deadline 24 Aug 2026 | Viewed by 298 | Submission Open
Keywords: cerebellar neurons; cerebellar synapses; cerebellar circuit organization; cerebellar function; cerebellar disorders; cerebellar learning and behavior
(This special issue belongs to the Section Cellular Neuroscience)
Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants
edited by Aziz Khan and
submission deadline 25 Aug 2026 | 2 articles | Viewed by 13600 | Submission Open
Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives
edited by Peter Van Endert
submission deadline 25 Aug 2026 | 2 articles | Viewed by 2985 | Submission Open
Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy
Molecular Mechanisms of Trophoblast Differentiation
edited by Milica Jovanović Krivokuća and
submission deadline 25 Aug 2026 | 1 articles | Viewed by 1066 | Submission Open
Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation
Cell and Molecular Mechanisms of Cytogenesis submission deadline 25 Aug 2026 | Viewed by 790 | Submission Open
Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders
Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms
edited by Masmoudi-Kouki Olfa and
submission deadline 25 Aug 2026 | Viewed by 378 | Submission Open
Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling
(This special issue belongs to the Section Stem Cells)
Role of Oxidative Stress in Cardiovascular Diseases submission deadline 25 Aug 2026 | Viewed by 345 | Submission Open
Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Critical Topics in Plant, Algae and Fungi Cell Biology
edited by
submission deadline 25 Aug 2026 | Viewed by 226 | Submission Open
Keywords: cells; molecules; signaling; functions; development; methods; technologies
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
From Protection to Pathology: Beneficial and Deleterious Roles of Extracellular Vesicle Cargo
edited by
submission deadline 25 Aug 2026 | Viewed by 173 | Submission Open
Keywords: extracellular vesicle cargo profiling; exosome cargo heterogeneity; EV cargo modulation; small EV bioengineering; therapeutic cargo loading; engineered exosomes; targeted EV delivery
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Molecular Mechanisms and Novel Therapeutics for Glioblastoma
edited by Hirotaka Ito and Raziye Piranlioglu
submission deadline 25 Aug 2026 | Viewed by 156 | Submission Open
Keywords: glioblastoma; molecular mechanisms; oncolytic virus therapy; immunotherapy; tumor microenvironment; translational research; neurosurgery
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
edited by and Olufunto Badmus
submission deadline 25 Aug 2026 | Viewed by 148 | Submission Open
Keywords: NAFLD; MASLD; hepatic steatosis; obesity; insulin resistance; fibrosis; cirrhosis
(This special issue belongs to the Section Cellular Pathology)
New Trends and Advances in Induced Neural Cells and iPSC Technologies
edited by
submission deadline 28 Aug 2026 | 1 articles | Viewed by 1326 | Submission Open
Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling
(This special issue belongs to the Section Cellular Neuroscience)
Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies
edited by
submission deadline 30 Aug 2026 | 5 articles | Viewed by 7330 | Submission Open
Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies
(This special issue belongs to the Section Cellular Immunology)
Signal Transduction and Targeted Therapy for Tumors submission deadline 30 Aug 2026 | 5 articles | Viewed by 7137 | Submission Open
Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy
(This special issue belongs to the Section Cell Signaling)
Aging and Neurodegeneration: Molecular Insights and Emerging Strategies submission deadline 30 Aug 2026 | 2 articles | Viewed by 6703 | Submission Open
Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research
(This special issue belongs to the Section Cellular Aging)
Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses
edited by
submission deadline 30 Aug 2026 | 4 articles | Viewed by 3109 | Submission Open
Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Aug 2026 | 1 articles | Viewed by 2406 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting
edited by
submission deadline 30 Aug 2026 | 1 articles | Viewed by 2160 | Submission Open
Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment
Cellular Responses During Wound and Regeneration submission deadline 30 Aug 2026 | 2 articles | Viewed by 1414 | Submission Open
Keywords: inflammation; wound and regeneration; clotting; reduction– oxidation reactions; fibroblasts; proliferation; endothelial; extracellular matrix
(This special issue belongs to the Section Stem Cells)
The Lipid Metabolism and Signaling in Dry Eye Disease
edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak
submission deadline 30 Aug 2026 | Viewed by 375 | Submission Open
Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms
Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes
edited by and Subhash Chandra Sethi
submission deadline 30 Aug 2026 | Viewed by 230 | Submission Open
Keywords: chromatin organization; chromatin remodelers; epigenetic modifications; epigenetic modifiers; chromosome segregation; transcription; DNA replication; DNA damage and repair; cancer; aging
(This special issue belongs to the Section Cell and Gene Therapy)
Molecular and Cellular Mechanisms and Novel Therapies of Ocular Disease
edited by Valery I. Shestopalov
submission deadline 30 Aug 2026 | Viewed by 138 | Submission Open
Keywords: ocular disease; neuroprotection; regeneration
(This special issue belongs to the Section Cellular Pathology)
New Advances in Targeted Therapy for Solid Tumor
edited by Jung Eun Park
submission deadline 30 Aug 2026 | Viewed by 119 | Submission Open
Keywords: CAR-X cells; antibody– drug conjugates (ADCs); bispecific/multi-specific antibodies; PROTACs; tumor microenvironment (TME); immune checkpoint blockade; metabolic reprogramming; patient-derived organoids (PDOs); 3D bioprinting
(This special issue belongs to the Section Cellular Pathology)
The Role of Cilia in Health and Diseases—2nd Edition
edited by Rim Hjeij
submission deadline 31 Aug 2026 | 6 articles | Viewed by 15143 | Submission Open
Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Aug 2026 | 6 articles | Viewed by 11966 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
Role of Alpha-Synuclein in Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 5060 | Submission Open
Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases
(This special issue belongs to the Section Cellular Aging)
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Aug 2026 | 2 articles | Viewed by 4417 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
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