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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Gene Regulation in Neurological Disorders

edited by

Yujing Li

and Yulin Jin

submission deadline 20 Aug 2026 | 3 articles | Viewed by 4633 | Submission Open

Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)

(This special issue belongs to the Section Cell and Gene Therapy)

Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition

edited by

Yung-Hsin Yeh

and

Ying-Ju Lai

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3664 | Submission Open

Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction

(This special issue belongs to the Section Cellular Pathology)

Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

edited by

Yuhao Xie

Concettina La Motta

and Rakesh Kumar Srivastava

submission deadline 20 Aug 2026 | 3 articles | Viewed by 3299 | Submission Open

Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers

Small-Molecule Approaches to Counteract Demyelination and Neurodegeneration

edited by David Lutz

submission deadline 20 Aug 2026 | 2 articles | Viewed by 2026 | Submission Open

Keywords: demyelination; neurorepair; small-molecule therapeutics; neurodegeneration

(This special issue belongs to the Section Cellular Neuroscience)

Autophagy-Related Proteins in Stress Responses

edited by

Aurore Claude-Taupin

submission deadline 20 Aug 2026 | 1 articles | Viewed by 936 | Submission Open

Keywords: stress response; ATG; endocytosis; exocytosis; autophagy

(This special issue belongs to the Section Autophagy)

Mesenchymal Stem Cells in Cell Therapy, Regenerative Medicine, and Tissue Engineering

edited by

Marta Kot

and

Joni H. Ylostalo

submission deadline 20 Aug 2026 | 2 articles | Viewed by 537 | Submission Open

Keywords: mesenchymal stem cells (MSCs); tissue engineering and scaffolds; regenerative medicine; cell-based therapies; differentiation and immunomodulation

(This special issue belongs to the Section Stem Cells)

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by

Paul D. Coleman

and Benjamin Wolozin

submission deadline 20 Aug 2026 | Viewed by 335 | Submission Open

Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Pathological Mechanisms and Therapeutic Strategies of Alzheimer’s Disease

edited by Boris DeCourt, Travis Thompson and

Andrew C. Shin

submission deadline 20 Aug 2026 | Viewed by 296 | Submission Open

Keywords: Alzheimer’ s disease; amyloid beta; biomarkers; gut-brain axis; mechanisms; neurotransmitter imbalance; pathology; tau; treatments

(This special issue belongs to the Section Cellular Aging)

The Circulating Tumor Microenvironment (cTME): Emerging Taxonomies and Multimodal Landscapes

edited by

Noriyoshi Sawabata

submission deadline 20 Aug 2026 | Viewed by 170 | Submission Open

Keywords: circulating tumor microenvironment (cTME); circulating tumor-associated cells (C-TACs); circulating tumor emboli (CTE); extracellular vesicles; metastatic cascade; experimental cytology; functional assays; precision oncology; liquid biopsy; next-generation sequencing (NGS)

(This special issue belongs to the Section Cell Microenvironment)

Metabolic, Signaling, and Transcriptomic Regulation of NK Cell Development and Functions

edited by

Subramaniam Malarkannan

submission deadline 20 Aug 2026 | Viewed by 162 | Submission Open

Keywords: NK cells; immunometabolism; mTOR; AMPK; JAK– STAT; checkpoint signaling; transcription factors; enhancers; epigenetics; chromatin accessibility; single-cell multi-omics; spatial transcriptomics; tumor microenvironment; immunotherapy; transplantation

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Insights into Age-Related Macular Degeneration

edited by

Neetu Kushwah

and

Raphaël Roduit

submission deadline 20 Aug 2026 | Viewed by 136 | Submission Open

Keywords: age-related macular degeneration (AMD); lipid metabolism/lipid dysregulation; retinal pigment epithelium (RPE); photoreceptors; complement system/complement dysregulation; neurodegeneration; retinal degeneration

(This special issue belongs to the Section Cellular Aging)

The Cerebellum: New Neurons, Circuits and Functions

edited by

George Augustine

and Jinsook Kim

submission deadline 24 Aug 2026 | Viewed by 318 | Submission Open

Keywords: cerebellar neurons; cerebellar synapses; cerebellar circuit organization; cerebellar function; cerebellar disorders; cerebellar learning and behavior

(This special issue belongs to the Section Cellular Neuroscience)

Cellular and Molecular Mechanisms of Abiotic Stress Tolerance in Plants

edited by Aziz Khan and

Xin Zhang

submission deadline 25 Aug 2026 | 3 articles | Viewed by 13779 | Submission Open

Keywords: abiotic stress; molecular mechanism; gene expression; cellular adaptation; signal transduction; plant physiology; molecular pathway; stress resilience; crop productivity; agronomic performance

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives

edited by Peter Van Endert

submission deadline 25 Aug 2026 | 2 articles | Viewed by 3372 | Submission Open

Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy

Molecular Mechanisms of Trophoblast Differentiation

edited by Milica Jovanović Krivokuća and

Jianjun Wei

submission deadline 25 Aug 2026 | 1 articles | Viewed by 1123 | Submission Open

Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation

Cell and Molecular Mechanisms of Cytogenesis

edited by

Luisa Alexandra Meireles Pinto

and

Teresa Correia Soares Canedo Calado

submission deadline 25 Aug 2026 | Viewed by 842 | Submission Open

Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Aug 2026 | Viewed by 398 | Submission Open

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

Role of Oxidative Stress in Cardiovascular Diseases

edited by

Nevena Jeremic

and

Vladimir Jakovljevic

submission deadline 25 Aug 2026 | Viewed by 366 | Submission Open

Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Critical Topics in Plant, Algae and Fungi Cell Biology

edited by

Andrei Smertenko

submission deadline 25 Aug 2026 | Viewed by 246 | Submission Open

Keywords: cells; molecules; signaling; functions; development; methods; technologies

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

From Protection to Pathology: Beneficial and Deleterious Roles of Extracellular Vesicle Cargo

edited by

Mousumi Ghosh

submission deadline 25 Aug 2026 | Viewed by 186 | Submission Open

Keywords: extracellular vesicle cargo profiling; exosome cargo heterogeneity; EV cargo modulation; small EV bioengineering; therapeutic cargo loading; engineered exosomes; targeted EV delivery

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Molecular Mechanisms and Novel Therapeutics for Glioblastoma

edited by Hirotaka Ito and Raziye Piranlioglu

submission deadline 25 Aug 2026 | Viewed by 163 | Submission Open

Keywords: glioblastoma; molecular mechanisms; oncolytic virus therapy; immunotherapy; tumor microenvironment; translational research; neurosurgery

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by

David E. Stec

and Olufunto Badmus

submission deadline 25 Aug 2026 | Viewed by 161 | Submission Open

Keywords: NAFLD; MASLD; hepatic steatosis; obesity; insulin resistance; fibrosis; cirrhosis

(This special issue belongs to the Section Cellular Pathology)

New Trends and Advances in Induced Neural Cells and iPSC Technologies

edited by

Guoqiang Sun

submission deadline 28 Aug 2026 | 1 articles | Viewed by 1636 | Submission Open

Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling

(This special issue belongs to the Section Cellular Neuroscience)

Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 30 Aug 2026 | 5 articles | Viewed by 7724 | Submission Open

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Signal Transduction and Targeted Therapy for Tumors

edited by

Rodolfo Daniel Cervantes-Villagrana

submission deadline 30 Aug 2026 | 5 articles | Viewed by 7473 | Submission Open

Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy

(This special issue belongs to the Section Cell Signaling)

Aging and Neurodegeneration: Molecular Insights and Emerging Strategies

edited by

Piotr Paweł Chmielewski

submission deadline 30 Aug 2026 | 2 articles | Viewed by 6817 | Submission Open

Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research

(This special issue belongs to the Section Cellular Aging)

Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses

edited by

Edit Tóth-Molnár

submission deadline 30 Aug 2026 | 4 articles | Viewed by 3308 | Submission Open

Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies

Redox Regulation by Nrf2 in Health and Disease

edited by Pandu Gangula

submission deadline 30 Aug 2026 | 1 articles | Viewed by 2477 | Submission Open

Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 30 Aug 2026 | 1 articles | Viewed by 2285 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

Cellular Responses During Wound and Regeneration

edited by

Eric A. Albrecht

and

Rebecca A. Wingert

submission deadline 30 Aug 2026 | 2 articles | Viewed by 1535 | Submission Open

Keywords: inflammation; wound and regeneration; clotting; reduction– oxidation reactions; fibroblasts; proliferation; endothelial; extracellular matrix

(This special issue belongs to the Section Stem Cells)

The Lipid Metabolism and Signaling in Dry Eye Disease

edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak

submission deadline 30 Aug 2026 | Viewed by 384 | Submission Open

Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms

Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes

edited by

Roshan L. Shrestha

and Subhash Chandra Sethi

submission deadline 30 Aug 2026 | Viewed by 234 | Submission Open

Keywords: chromatin organization; chromatin remodelers; epigenetic modifications; epigenetic modifiers; chromosome segregation; transcription; DNA replication; DNA damage and repair; cancer; aging

(This special issue belongs to the Section Cell and Gene Therapy)

Molecular and Cellular Mechanisms and Novel Therapies of Ocular Disease

edited by Valery I. Shestopalov

submission deadline 30 Aug 2026 | Viewed by 150 | Submission Open

Keywords: ocular disease; neuroprotection; regeneration

(This special issue belongs to the Section Cellular Pathology)

New Advances in Targeted Therapy for Solid Tumor

edited by Jung Eun Park

submission deadline 30 Aug 2026 | Viewed by 130 | Submission Open

Keywords: CAR-X cells; antibody– drug conjugates (ADCs); bispecific/multi-specific antibodies; PROTACs; tumor microenvironment (TME); immune checkpoint blockade; metabolic reprogramming; patient-derived organoids (PDOs); 3D bioprinting

(This special issue belongs to the Section Cellular Pathology)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 31 Aug 2026 | 6 articles | Viewed by 15372 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Aug 2026 | 6 articles | Viewed by 12631 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Role of Alpha-Synuclein in Neurodegenerative Diseases

edited by

Carmela Conte

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5208 | Submission Open

Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases

(This special issue belongs to the Section Cellular Aging)

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Aug 2026 | 2 articles | Viewed by 4505 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases

edited by

Sweta Ghosh

and Subir Kumar Juin

submission deadline 31 Aug 2026 | 2 articles | Viewed by 4031 | Submission Open

Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease

Molecular Mechanisms Underlying Inflammatory Pain

edited by

Luke A. Pattison

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3699 | Submission Open

Keywords: molecular mechanisms; inflammatory pain; nociception; neuronal sensitization; neuroimmune interactions

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2817 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

The Spatial and Temporal Dynamics of the Tumor Microenvironment

edited by

Shilpa Bisht

, Abhishek Gupta, Anjali Trivedi and

Alessandra Ferraresi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2001 | Submission Open

Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches

(This special issue belongs to the Section Cell Microenvironment)

Inflammation and Aging in Acute and Chronic Kidney Injury

edited by

Massimiliano Migliori

Vincenzo Cantaluppi

and

Marita Marengo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1925 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; aging

(This special issue belongs to the Section Cellular Aging)

New Molecular Insights into Hepatitis and Hepatic Cancer

edited by

Mark A. Feitelson

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1726 | Submission Open

Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances

(This special issue belongs to the Section Cellular Pathology)

Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities

edited by Fabio Guolo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1662 | Submission Open

Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers

(This special issue belongs to the Section Cellular Immunology)

Advances in CAR Cell Therapies and Manufacturing

edited by William J. Kelly and Madhuresh C. Sumit

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1596 | Submission Open

Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines

Lipoprotein and Cardiovascular Diseases Therapy

edited by Verity Ramirez and Wenliang Song

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1338 | Submission Open

Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy

(This special issue belongs to the Section Cells of the Cardiovascular System)

Gene and Cell Therapy in Regenerative Medicine—Third Edition

edited by

Albert Rizvanov

and

Ayşegül Doğan

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1328 | Submission Open

Keywords: gene therapy; cell therapy; regenerative medicine; growth factors; stem cells

(This special issue belongs to the Section Cell and Gene Therapy)

Mechanisms and Biomarkers of Neurotoxicity: From Molecular Pathways to Therapeutic Interventions

edited by Nyzil Massey, Shreesh Raj Sammi and

Diou Luo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 960 | Submission Open

Keywords: neurotoxicity mechanisms; neuroinflammation; oxidative stress; biomarkers; neuroimaging; electrophysiology; glial activation; neurodegeneration; translational therapeutics; environmental neurotoxicology

(This special issue belongs to the Section Cellular Neuroscience)

Gastrointestinal Cancers: Research, Novel Diagnostic and Treatment Methods

edited by

Jens Hahne

and Michele Ghidini

submission deadline 31 Aug 2026 | 1 articles | Viewed by 510 | Submission Open

Keywords: gastrointestinal cancer; diagnostic; treatment options

(This special issue belongs to the Section Cellular Pathology)

Displaying special issue 301-350 on page 7 of 14.

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