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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Brain Development and Neurodevelopmental Disorders

edited by

Mojgan Rastegar

submission deadline 30 Nov 2025 | Viewed by 296 | Submission Open

Keywords: brain development; neural stem cells; neurodevelopmental disorders; brain diseases; cellular and molecular mechanisms; embryonic and adult brain

(This special issue belongs to the Section Cellular Pathology)

Drug Resistance in Breast and Ovarian Cancers

edited by

Tuula Kallunki

submission deadline 30 Nov 2025 | Viewed by 272 | Submission Open

Keywords: breast cancer; endocrine resistance; ESR1 mutations; Trop-2; ovarian cancer; drug resistance; predictive biomarkers; personalized medicine

CRISPR-Based Genome Editing Approaches in Cancer Therapy

edited by Martin Pal

submission deadline 30 Nov 2025 | Viewed by 229 | Submission Open

Keywords: CRISPR; genome editing; cancer therapy; precision medicine

(This special issue belongs to the Section Cell and Gene Therapy)

Brain Organoids for Disease Modeling

edited by

Jonghun Kim

submission deadline 30 Nov 2025 | Viewed by 172 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening

(This special issue belongs to the Section Stem Cells)

Exploring Morphological Changes and Diversity in Cancer

edited by

Mustapha Kandouz

submission deadline 30 Nov 2025 | Viewed by 171 | Submission Open

Keywords: morphology; heterogeneity; cancer; phenotype; shape

Non-Coding RNAs as Regulators of Cellular Function and Disease

edited by

Lucia Natarelli

submission deadline 30 Nov 2025 | Viewed by 164 | Submission Open

Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms

Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity

edited by Jiabei Lin

submission deadline 30 Nov 2025 | Viewed by 161 | Submission Open

Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer

Adipose-Derived Stem Cells for Tissue Regeneration

edited by

Lukas Prantl, MD, PhD, MHBA, FACS

submission deadline 30 Nov 2025 | Viewed by 123 | Submission Open

Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies

(This special issue belongs to the Section Tissues and Organs)

Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection

edited by Sauri Hernandez-Resendiz

submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open

Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection

(This special issue belongs to the Section Tissues and Organs)

ROS in Atherosclerosis and Cardiometabolic Disorders

edited by

Weibin Shi

submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open

Keywords: reactive oxygen/nitrogen species; oxidative stress; atherosclerosis; cardiovascular; inflammation; endothelial dysfunction; obesity; dyslipidemia

(This special issue belongs to the Section Tissues and Organs)

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Nov 2025 | Viewed by 83 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Research in Osteoporosis

edited by

Virginia Visconti

Annalisa Botta

and

Umberto Tarantino

submission deadline 30 Nov 2025 | Viewed by 73 | Submission Open

Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy

(This special issue belongs to the Section Cellular Pathology)

Molecular Mechanisms of Drug Delivery in Ophthalmology

edited by Alekha K. Dash and Surabhi Shukla

submission deadline 30 Nov 2025 | Viewed by 73 | Submission Open

Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery

(This special issue belongs to the Section Tissues and Organs)

Redox Regulation by Nrf2 in Health and Disease

edited by Pandu Gangula

submission deadline 30 Nov 2025 | Viewed by 67 | Submission Open

Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response

Microautophagy: The Least Known of the Autophagy Strategies

edited by

Patrice X. Petit

submission deadline 30 Nov 2025 | Viewed by 67 | Submission Open

Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs

(This special issue belongs to the Section Autophagy)

The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention

edited by Vivek Kumar Kashyap and Himanshu Narayan Singh

submission deadline 30 Nov 2025 | Viewed by 57 | Submission Open

Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors

(This special issue belongs to the Section Cellular Pathology)

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 30 Nov 2025 | Viewed by 57 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Protein and RNA Regulation in Cells

edited by

Delai Huang

and

Denis Mottet

submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open

Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay

Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine

edited by Renata Kelly Da Palma

submission deadline 30 Nov 2025 | Viewed by 50 | Submission Open

Keywords: cell therapy; lung diseases; tissue regeneration

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms of Hepatobiliary Diseases

edited by

Stefan Hoehme

and

Jan G. Hengstler

submission deadline 30 Nov 2025 | Viewed by 46 | Submission Open

Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics

edited by Mangesh Dattu Hade

submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open

Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Mechanisms of Wound Repair

edited by

Elia Ranzato

submission deadline 30 Nov 2025 | Viewed by 42 | Submission Open

Keywords: wound healing; cellular mechanisms; tissue remodeling; growth factors; extracellular matrix; tissue regeneration

(This special issue belongs to the Section Cellular Pathology)

Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments

edited by Konrad Talbot

submission deadline 30 Nov 2025 | Viewed by 40 | Submission Open

Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease

(This special issue belongs to the Section Cells of the Nervous System)

Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities

edited by

Sherri R. Cervantes

and

Daruka Mahadevan

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer

(This special issue belongs to the Section Cell Microenvironment)

New Advances in Cardiac and Vascular Physiology

edited by Robert M. Lust

submission deadline 30 Nov 2025 | Viewed by 23 | Submission Open

Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure

(This special issue belongs to the Section Tissues and Organs)

The Spatial and Temporal Dynamics of the Tumor Microenvironment

edited by

Shilpa Bisht

, Abhishek Gupta, Anjali Trivedi and

Alessandra Ferraresi

submission deadline 1 Dec 2025 | Viewed by 348 | Submission Open

Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches

(This special issue belongs to the Section Cell Microenvironment)

Advances in Pulmonary Fibrosis

edited by Sergio Piñeiro Hermida

submission deadline 1 Dec 2025 | Viewed by 150 | Submission Open

Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics

(This special issue belongs to the Section Cellular Pathology)

The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders

edited by

Pei-Hui Lin

and

Kumaraswami Konda

submission deadline 5 Dec 2025 | 6 articles | Viewed by 12987 | Submission Open

Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair

(This special issue belongs to the Section Cellular Immunology)

New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis

edited by

Francesc Mitjans

submission deadline 10 Dec 2025 | 2 articles | Viewed by 3429 | Submission Open

Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody

(This special issue belongs to the Section Cell Microenvironment)

Therapeutic Mechanism of Nervous System Inflammation—Second Edition

edited by

Maria Anttonietta Panaro

and

Antonia Cianciulli

submission deadline 10 Dec 2025 | 1 articles | Viewed by 1393 | Submission Open

Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system

(This special issue belongs to the Section Cells of the Nervous System)

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Dec 2025 | Viewed by 386 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Stem Cells)

Role of Ras-Regulated Signal Pathways

edited by

Takayuki Tsukuba

submission deadline 10 Dec 2025 | Viewed by 225 | Submission Open

Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway

(This special issue belongs to the Section Cell Signaling)

Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma

edited by

Swapan K. Ray

submission deadline 15 Dec 2025 | 21 articles | Viewed by 62847 | Submission Open

Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities

(This special issue belongs to the Section Cells of the Nervous System)

New Advances in Neuroinflammation

edited by

John W. Chen

and Michael Breckwoldt

submission deadline 15 Dec 2025 | 14 articles | Viewed by 45543 | Submission Open

Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging

(This special issue belongs to the Section Cells of the Nervous System)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 15 Dec 2025 | 6 articles | Viewed by 14339 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Mitochondria and Metabolism in Cancer Stem Cells (CSCs)

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2885 | Submission Open

Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches

(This special issue belongs to the Section Stem Cells)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1494 | Submission Open

Keywords: cellular therapies; cancer; immune

DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications

edited by

Michele Longo

and

Jyotirmoy Das

submission deadline 15 Dec 2025 | Viewed by 615 | Submission Open

Keywords: DNA methylation; epigenetics; diseases; biomarkers; functional analysis

(This special issue belongs to the Section Cellular Pathology)

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Dec 2025 | 1 articles | Viewed by 583 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Exclusive Review Papers in Parkinson's Research

edited by

Wolfgang Jost

and Ronald F. Pfeiffer

submission deadline 15 Dec 2025 | Viewed by 245 | Submission Open

Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa

(This special issue belongs to the Section Cellular Aging)

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Dec 2025 | Viewed by 84 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Dec 2025 | Viewed by 82 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cells of the Nervous System)

Physics of Cancer: How Mechanobiology Drives Cancer Progression

edited by

Claudia Tanja Mierke

submission deadline 15 Dec 2025 | Viewed by 74 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

The Symphony of Nature—the Precision of Life’s Regulation

edited by Weiguang Wang and Baocheng Liu

submission deadline 15 Dec 2025 | Viewed by 54 | Submission Open

Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding

(This special issue belongs to the Section Cell Methods)

Advanced Research in Neurogenesis and Neuroinflammation

edited by

Muskan Gupta

submission deadline 15 Dec 2025 | Viewed by 49 | Submission Open

Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions

(This special issue belongs to the Section Cells of the Nervous System)

Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition

edited by

Zhuo Wang

submission deadline 15 Dec 2025 | Viewed by 45 | Submission Open

Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition

(This special issue belongs to the Section Tissues and Organs)

The Cross-Talk Between Obesity and Metabolism

edited by

Hong Shi

submission deadline 15 Dec 2025 | Viewed by 44 | Submission Open

Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets

The Role of Extracellular Vesicles in Kidney Disease

edited by

Amankeldi Salybekov

and Ciro Tetta

submission deadline 15 Dec 2025 | Viewed by 41 | Submission Open

Keywords: extracellular vesicles (EVs); microRNAs (miRs); chronic kidney disease (CKD); acute kidney injury (AKI); regenerative medicine; biomarkers; artificial intelligence (AI); nephrology; urology; precision medicine

(This special issue belongs to the Section Cell Microenvironment)

AMPK: From Mechanisms to New Therapies

edited by

Roland Abi Nahed

and

Farah Diab

submission deadline 15 Dec 2025 | Viewed by 39 | Submission Open

Keywords: metabolism; AMPK; cancer; biosensors; reproduction; metabolic disorders; therapies

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 15 Dec 2025 | Viewed by 33 | Submission Open