Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer Cell Signaling, Autophagy and Tumorigenesis
edited by Debanjan Bhattacharya
submission deadline 20 Mar 2026 | Viewed by 263 | Submission Open
Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway
Chronic Obstructive Pulmonary Disease (COPD): From Molecular and Cellular Mechanisms to Therapeutic Opportunities
edited by , Bradley W. Richmond and
submission deadline 20 Mar 2026 | Viewed by 202 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); small airway disease; vascular remodeling; emphysema
(This special issue belongs to the Section Cellular Immunology)
Cell and Molecular Mechanisms of Cytogenesis submission deadline 20 Mar 2026 | Viewed by 181 | Submission Open
Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders
Cellular and Molecular Mechanisms of Neurotoxicity
edited by , , Tiziana Cotrufo and
submission deadline 20 Mar 2026 | Viewed by 134 | Submission Open
Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate
Novel Insights into Endothelial Cells in Vascular Disease
edited by
submission deadline 20 Mar 2026 | Viewed by 126 | Submission Open
Keywords: endothelial cells; vascular diseases; vascular signaling
Novel Immunotherapies for Diffuse Large B-Cell Lymphoma
edited by
submission deadline 20 Mar 2026 | Viewed by 92 | Submission Open
Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody– drug conjugates; tumor microenvironment; biomarkers; translational research
Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease
edited by and Museer Ahmad Lone
submission deadline 25 Mar 2026 | 3 articles | Viewed by 5569 | Submission Open
Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation
(This special issue belongs to the Section Cellular Biophysics)
The Silent Regulators: Non-Coding RNAs in Cell Function and Disease submission deadline 25 Mar 2026 | 4 articles | Viewed by 2745 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics
(This special issue belongs to the Section Cell and Gene Therapy)
Ischemic Heart Disease: From Cellular Level to Clinical Approaches submission deadline 25 Mar 2026 | 1 articles | Viewed by 552 | Submission Open
Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy
Gene Editing Therapies for Hereditary Diseases submission deadline 25 Mar 2026 | Viewed by 269 | Submission Open
Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases
(This special issue belongs to the Section Cell and Gene Therapy)
Cell and Molecular Mechanisms of Bacterial Meningitis submission deadline 25 Mar 2026 | Viewed by 158 | Submission Open
Keywords: bacterial meningitis; innate immunity; inflammation; immune response; central nervous system; neuron; microglia; astrocytes; granulocytes; blood– brain barrier
Mitochondria: Multifaceted Regulators of Cell Death
edited by Rasa Banienė and Sonata Trumbeckaite
submission deadline 25 Mar 2026 | Viewed by 151 | Submission Open
Keywords: mitochondria; cell death; multifaceted regulators; reactive oxygen species (ROS); cell metabolism; mitochondrial transfer
From Signals to Shape: Molecular Control of Cellular Plasticity Through Epigenetic, Transcriptomic, and Immune Mechanisms submission deadline 25 Mar 2026 | Viewed by 148 | Submission Open
Keywords: cellular plasticity; epigenetics; transcriptomics; mechanotransduction; immune signaling; cell fate regulation; RNA methylation; biomaterials interaction; molecular cytology; cell adaptation
Cancer Stem Cells in Triple-Negative Breast Cancer submission deadline 25 Mar 2026 | Viewed by 126 | Submission Open
Keywords: cancer stem cells; TNBC; signal pathways; epithelial– mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers
Breaking the Balance: Cellular Stress, Proteostasis, Aggregates and Neurodegeneration
edited by
submission deadline 25 Mar 2026 | Viewed by 121 | Submission Open
Keywords: proteostasis; cellular stress; protein aggregation; neurodegeneration; autophagy; unfolded protein response; oxidative stress; aging; molecular chaperones; protein quality control
Molecular Mechanisms of Trophoblast Differentiation
edited by Milica Jovanović Krivokuća and
submission deadline 25 Mar 2026 | Viewed by 120 | Submission Open
Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation
Biomarkers and Therapeutic Targets in Insulin Resistance
edited by
submission deadline 30 Mar 2026 | 1 articles | Viewed by 2555 | Submission Open
Keywords: insulin resistance; biomarkers; therapeutic targets; type 2 diabetes; metabolic syndrome; obesity; molecular mechanisms; pharmacologic treatments; precision medicine; cardiovascular diseases
(This special issue belongs to the Section Cellular Pathology)
Neuroimaging of Cerebrovascular Diseases
edited by Dragan Stojanov
submission deadline 30 Mar 2026 | Viewed by 197 | Submission Open
Keywords: neuroimaging; cerebrovascular diseases; stroke; intracerebral hemorrhage; SAHA neurysms; AVM; small vessels diseases; CT; MRI; advance MRI techniques; DSA; AI
Mechanisms of miRNA Metabolism and Extracellular Transport submission deadline 30 Mar 2026 | Viewed by 182 | Submission Open
Keywords: miRNA metabolism; miRNA transport; miRNA exchange; miRNA storage; mRNA biogenesis; extracellular vesicles and miRNA; non-EV miRNA export; miRNA binding proteins; miRNA sponge and inhibitors; miRNA biomarkers
Novel Insights into Cancer Immune Responsiveness submission deadline 30 Mar 2026 | Viewed by 158 | Submission Open
Keywords: cancers; tumors; immune cells; tumor immunology; cancer immunology; onco-immunology; immunotherapies; resistance; immunotherapy resistance; immune checkpoint; CAR; antibody; cancer vaccines
Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain submission deadline 30 Mar 2026 | 1 articles | Viewed by 134 | Submission Open
Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors
(This special issue belongs to the Section Cellular Pathology)
Impact of Chronic Substance Exposure on Hematopoiesis and Immunity
edited by and
submission deadline 30 Mar 2026 | Viewed by 121 | Submission Open
Keywords: Substance Use Alcohol Immunity Inflammation Hematopoietic stem and progenitor cells Monocytes Neutrophils Macrophages T cells
Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment
edited by
submission deadline 30 Mar 2026 | Viewed by 116 | Submission Open
Keywords: tumor microenvironment; drug delivery; nanoparticle
(This special issue belongs to the Section Cell Methods)
Cellular and Molecular Mechanisms of Cardiomyopathy submission deadline 30 Mar 2026 | Viewed by 108 | Submission Open
Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis
(This special issue belongs to the Section Tissues and Organs)
Molecular Mechanisms and Biomarker Development in Prostate Cancer
edited by Vikas Mehta and Behtash Ghazi Nezami
submission deadline 30 Mar 2026 | Viewed by 83 | Submission Open
Keywords: androgen receptor; prostate molecular alterations; biomarkers
Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders submission deadline 31 Mar 2026 | 5 articles | Viewed by 25108 | Submission Open
Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections
(This special issue belongs to the Section Cellular Immunology)
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2026 | 3 articles | Viewed by 13575 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 8293 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
mRNA Vaccines and Therapeutics in Melanoma: From Mechanisms to Cellular Impact submission deadline 31 Mar 2026 | 3 articles | Viewed by 6972 | Submission Open
Keywords: mRNA vaccines; melanoma; tumor immunology; mRNA vaccine designs; delivery systems
(This special issue belongs to the Section Cellular Pathology)
Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches
edited by Yuxiang Xie and Jingqi Yan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 4031 | Submission Open
Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies
(This special issue belongs to the Section Cellular Neuroscience)
Signaling Pathways Involved in Tumor Microenvironment and Tumor Adaptation to Stresses
edited by Nianli Sang
submission deadline 31 Mar 2026 | 2 articles | Viewed by 3967 | Submission Open
Keywords: microenvironment; metabolic stress; hypoxia; chemoresistance; radiation resistance; apoptosis; metabolic reprogramming; metastasis
(This special issue belongs to the Section Cell Signaling)
Advances in Reproductive Biology: Cellular and Molecular Mechanisms
edited by and Clara González-Marín
submission deadline 31 Mar 2026 | 3 articles | Viewed by 3516 | Submission Open
Keywords: gametogenesis; fertilization; embryo implantation; reproductive genetics; epigenetics in reproduction; hormonal signaling; stem cells and reproduction; assisted reproductive technologies (ARTs); molecular fertility regulation; reproductive health innovations
(This special issue belongs to the Section Reproductive Cells and Development)
Drosophila as a Model for Understanding Human Disease
edited by Zhe Han
submission deadline 31 Mar 2026 | 3 articles | Viewed by 3133 | Submission Open
Keywords: Drosophila melanogaster; human disease models; genetic and molecular mechanisms; neurodegenerative diseases; cardiovascular diseases; cancer biology; metabolic disorders; high-throughput screening; precision medicine; translational research
(This special issue belongs to the Section Cellular Pathology)
Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease submission deadline 31 Mar 2026 | 1 articles | Viewed by 2413 | Submission Open
Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management
(This special issue belongs to the Section Tissues and Organs)
Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells submission deadline 31 Mar 2026 | 1 articles | Viewed by 2407 | Submission Open
Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine
(This special issue belongs to the Section Stem Cells)
Molecular Insights into Vascular Physiology and Pathology
edited by Suravi Majumder
submission deadline 31 Mar 2026 | 3 articles | Viewed by 2092 | Submission Open
Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches
(This special issue belongs to the Section Cellular Pathology)
Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies submission deadline 31 Mar 2026 | 1 articles | Viewed by 1554 | Submission Open
Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1497 | Submission Open
Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors
(This special issue belongs to the Section Cellular Neuroscience)
Cellular Mechanisms in Pregnancy and Foetal Development submission deadline 31 Mar 2026 | 1 articles | Viewed by 1334 | Submission Open
Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth
From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria
edited by Amy H. Attaway and Saurabh Mishra
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1328 | Submission Open
Keywords: mitochondrial oxidation; ROS; aging; disease
The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1266 | Submission Open
Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering
The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival
edited by and Giulio Menegazzi
submission deadline 31 Mar 2026 | 1 articles | Viewed by 769 | Submission Open
Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration
edited by Mukund Srinivasan
submission deadline 31 Mar 2026 | 1 articles | Viewed by 478 | Submission Open
Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress
Cellular and Molecular Insights into Allergies and Allergic Diseases
edited by
submission deadline 31 Mar 2026 | Viewed by 316 | Submission Open
Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms
(This special issue belongs to the Section Cellular Immunology)
Mechanisms and Dynamics in Cellular Adhesion in Development and Disease
edited by
submission deadline 31 Mar 2026 | Viewed by 304 | Submission Open
Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction
Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections
edited by
submission deadline 31 Mar 2026 | Viewed by 274 | Submission Open
Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication
Current Research on Immunotherapy for Glioblastoma
edited by Markella Zannikou
submission deadline 31 Mar 2026 | Viewed by 225 | Submission Open
Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy
(This special issue belongs to the Section Cellular Immunology)
Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease
edited by Praveen Koganti and
submission deadline 31 Mar 2026 | Viewed by 225 | Submission Open
Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway
Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics
edited by
submission deadline 31 Mar 2026 | Viewed by 212 | Submission Open
Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis
Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 199 | Submission Open
Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies
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