Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 July 2025 | Viewed by 61
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria have long been known as the powerhouse of the cell; however, recent discoveries have revealed a far more dramatic reality. Mitochondria act as a platform for various cellular signaling cascades, including the metabolism of lipids and carbohydrates, calcium homeostasis, inflammation, hormone and steroid synthesis, and the regulation of cell death. Moreover, mitochondria coordinate cycles of fission and fusion, and they move along the cell to allow compensatory changes under stress conditions. Mitochondria do not exist in isolation. Rather, they associate and communicate with each other and other organelles such as the endoplasmic reticulum, plasma membrane, the nucleus, the Golgi apparatus, endosomes, peroxisomes, and even lipid droplets, to maintain biochemical homeostasis. Over the past decade, it has become clear that defects in mitochondrial function contribute to the development of many neurodegenerative diseases. Therefore, the determination of novel therapeutic strategies that mitigate mitochondrial dysfunction in is crucial.
This Special Issue welcomes the submission of original research articles, reviews, and perspectives that focus on the ability of therapeutic strategies to improve mitochondrial health in the context of neurodegenerative diseases. The scope of this Special Issue includes, but is not limited to, the following topics:
- The identification and characterization of novel molecular targets/pathways.
- Pharmacological agents and small molecules designed to improve mitochondrial function.
- The potential application of mitochondrial transplantation and cell-based therapies.
Dr. Patricia Morcillo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondria
- cellular signaling
- neurodegenerative diseases
- mitochondrial dynamics
- organelles
- neurological diseases
- therapies
- biomarkers
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
