Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 941
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitochondria have long been known as the powerhouse of the cell; however, recent discoveries have revealed a far more dramatic reality. Mitochondria act as a platform for various cellular signaling cascades, including the metabolism of lipids and carbohydrates, calcium homeostasis, inflammation, hormone and steroid synthesis, and the regulation of cell death. Moreover, mitochondria coordinate cycles of fission and fusion, and they move along the cell to allow compensatory changes under stress conditions. Mitochondria do not exist in isolation. Rather, they associate and communicate with each other and other organelles such as the endoplasmic reticulum, plasma membrane, the nucleus, the Golgi apparatus, endosomes, peroxisomes, and even lipid droplets, to maintain biochemical homeostasis. Over the past decade, it has become clear that defects in mitochondrial function contribute to the development of many neurodegenerative diseases. Therefore, the determination of novel therapeutic strategies that mitigate mitochondrial dysfunction in is crucial.
This Special Issue welcomes the submission of original research articles, reviews, and perspectives that focus on the ability of therapeutic strategies to improve mitochondrial health in the context of neurodegenerative diseases. The scope of this Special Issue includes, but is not limited to, the following topics:
- The identification and characterization of novel molecular targets/pathways.
- Pharmacological agents and small molecules designed to improve mitochondrial function.
- The potential application of mitochondrial transplantation and cell-based therapies.
Dr. Patricia Morcillo
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- cellular signaling
- neurodegenerative diseases
- mitochondrial dynamics
- organelles
- neurological diseases
- therapies
- biomarkers
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