Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".
Deadline for manuscript submissions: 30 August 2026 | Viewed by 17
Special Issue Editors
2. Developmental Therapeutics Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA
Interests: aneuploidy; genomic/chromosomal instability; microtubule dynamics; cell division; mitosis
Special Issue Information
Dear Colleagues,
This Special Issue will focus on chromatin plasticity and dynamics, which refer to the flexible and highly regulated structural states of chromatin that enable cells to control genome accessibility and function. It explores how chromatin architecture changes in response to developmental cues, environmental signals, and cellular stress, and how these structural transitions influence transcription, DNA replication, repair, epigenetic memory and cell division. By highlighting advances in imaging, sequencing technologies, and molecular approaches, the issue brings together insights into nucleosome remodeling, histone modifications, phase separation, and higher-order genome organization. Understanding these dynamic processes is essential for uncovering the mechanisms that maintain cellular identity and for identifying how chromatin misregulation contributes to human diseases, including cancer, aging, and developmental disorders.
Dr. Roshan L. Shrestha
Dr. Subhash Chandra Sethi
Guest Editors
Manuscript Submission Information
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Keywords
- chromatin organization
- chromatin remodelers
- epigenetic modifications
- epigenetic modifiers
- chromosome segregation
- transcription
- DNA replication
- DNA damage and repair
- cancer
- aging
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