Mechanisms and Biomarkers of Neurotoxicity: From Molecular Pathways to Therapeutic Interventions
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 1448
Editors
Interests: epilepsy; neurobehavior; neuroinflammation; neurotoxicity; nitro-oxidative stress; organophosphate nerve agents
Interests: neurotoxicology; polyfluoroalkyl substances; heavy metals; Alzheimer's disease; Parkinson’s disease; organophosphate pesticides; neuroscience
Special Issue Information
Dear Colleagues,
Neurotoxicity arises from diverse environmental, chemical, pharmacological, and endogenous insults that disrupt neural homeostasis across molecular, cellular, and systems levels. This Special Issue, “Mechanisms and Biomarkers of Neurotoxicity: From Molecular Pathways to Therapeutic Interventions,” aims to integrate emerging discoveries that elucidate how neurotoxic exposures reshape brain structure and function, and how these alterations can be detected, monitored, and ultimately mitigated. We welcome contributions that explore mechanistic pathways, including neuroinflammation, oxidative stress, mitochondrial dysfunction, excitotoxicity, and glial dysregulation, as drivers of acute and chronic neural injury. Particular emphasis will be placed on the identification and validation of multimodal biomarkers spanning molecular, imaging, electrophysiological, and behavioral domains that enhance early detection, prognostic assessment, and therapeutic monitoring.
This Special Issue also seeks studies that bridge experimental and translational gaps, highlighting innovative therapeutic strategies targeting key molecular and cellular pathways to prevent or reverse neurotoxic damage. Submissions addressing life-stage vulnerability, sex-dependent effects, and long-term neuropsychiatric consequences are especially encouraged. By integrating mechanistic insights with biomarker discovery and intervention strategies, this Special Issue aims to advance precision approaches for diagnosing, monitoring, and treating neurotoxicity across diverse exposure contexts.
Dr. Nyzil Massey
Dr. Shreesh Raj Sammi
Dr. Diou Luo
Guest Editors
Manuscript Submission Information
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Keywords
- neurotoxicity mechanisms
- neuroinflammation
- oxidative stress
- biomarkers
- neuroimaging
- electrophysiology
- glial activation
- neurodegeneration
- translational therapeutics
- environmental neurotoxicology
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