Redox Regulation by Nrf2 in Health and Disease

Dear Colleagues,

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of cellular antioxidant responses, playing a crucial role in maintaining redox homeostasis. This Special Issue of Cells aims to gather cutting-edge research that explores the diverse roles of Nrf2-mediated redox regulation across various biological systems and conditions. We invite submissions from researchers working on different aspects of Nrf2 biology, including but not limited to:

• Molecular Mechanisms: Studies elucidating the molecular mechanisms governing Nrf2 activation and regulation, including post-translational modifications, interactions with Keap1, and other regulatory proteins.
• Cellular Physiology: Investigations into how Nrf2 influences mitochondrial function, autophagy, apoptosis, and other fundamental cellular processes.
• Signaling Crosstalk: Research exploring the crosstalk between Nrf2 and other signaling pathways such as NF-κB, p53, and mTOR, and their implications for cell survival and stress response.
• Gene Expression and Epigenetics: Analyses of Nrf2-targeted genes and epigenetic modifications that contribute to antioxidant defense and cellular adaptation to oxidative stress.
• Inflammation and Immunity: Studies examining the role of Nrf2 in modulating inflammatory responses and immune functions.
• Pharmacological Modulation: Discoveries of novel pharmacological agents or natural compounds that target Nrf2 pathways for therapeutic purposes, focusing on preclinical models and mechanisms rather than clinical trials.
• Model Organisms and In Vitro Systems: Contributions using model organisms (e.g., yeast, C. elegans, Drosophila, zebrafish, mice) or in vitro systems to study Nrf2 function under physiological and pathological conditions.

By covering these broad areas, this Special Issue seeks to provide a comprehensive overview of the current state of knowledge regarding Nrf2's multifaceted roles in health and disease. We encourage submissions of original research articles, reviews, and perspectives that advance our understanding of Nrf2 biology and its potential applications in basic science and translational research.

We look forward to receiving high-quality contributions that will enrich our understanding of Nrf2’s critical functions in redox regulation and beyond.

Dr. Pandu Gangula
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Nrf2
• redox
• cellular stress response
• antioxidant gene regulation
• signaling pathway crosstalk
• oxidative stress response