Pathological Mechanisms and Therapeutic Strategies of Alzheimer’s Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 20 August 2026 | Viewed by 339
Special Issue Editors
Interests: Alzheimer’s disease; clinical trials; dementia; pharmacology; translational neuroscience
Interests: translational mathematical modeling; scientific machine learning; neurodegenerative disorders; metabolic disorders
Interests: brain metabolism; diabetes; metabolic disorders; neurodegenerative disorders; nutrition
Special Issue Information
Dear Colleagues,
Despite the approval of the first disease-modifying therapies by many international regulatory agencies, Alzheimer’s disease (AD) remains incurable while its incidence continuously increases. The amyloid cascade hypothesis has been extensively investigated in the past three decades, but the therapeutic interventions derived from these investigations have yielded modest results. Therefore, there is an urgent need to explore in-depth other existing and novel pathological mechanisms and therapeutic strategies to finally reach a point where cognitive decline and the underlying neuropathology stop, or reverse, in patients affected by this progressive neurodegenerative disease. For the present Special Issue of the journal Cells, we invite scientists from all over the world to submit manuscripts, including reviews, focused on Alzheimer’s pathological mechanisms and (novel) therapeutic strategies in the broad sense, both in human and pre-clinical models of AD. Articles on pathologies can report on amyloid and non-amyloid topics, including the emerging role of the gut–brain axis disturbances, underlying inflammatory conditions, neurotransmitter imbalances, or any other abnormal condition that could be involved in the neuropathogenesis or progression of AD. Articles on the modeling of Alzheimer’s pathology are also welcome. Reports on therapeutic interventions can describe pre-clinical and observational clinical studies or clinical trials using drugs, devices (ex. deep brain stimulation, transcranial ultrasound, magnetic, electrical stimulation), with or without combination of biomarker assessments, provided there is a focus on cellular mechanisms.
All articles submitted to this Special Issue will be assessed by our team of Guest Editors and, if fitting the topics of interest, peer-reviewed by specialists in the corresponding field of research.
Dr. Boris DeCourt
Dr. Travis Thompson
Dr. Andrew C. Shin
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Alzheimer’s disease
- amyloid beta
- biomarkers
- gut-brain axis
- mechanisms
- neurotransmitter imbalance
- pathology
- tau
- treatments
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