Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

Dear Colleagues,

Cancer remains a formidable global health challenge, necessitating continuous innovation in therapeutic strategies. Significant advancements in treatment have emerged from a deeper molecular understanding of cancer biology, leading to the identification of specific drug targets and the development of targeted therapies. However, despite these successes, the challenge of drug resistance frequently limits treatment efficacy and contributes to disease recurrence. This underscores the critical need for ongoing molecular research to not only discover novel targets but also to overcome the complex mechanisms by which cancer cells evade therapeutic agents.

Therefore, this Special Issue aims to compile cutting-edge original research and comprehensive review articles that advance our understanding of the molecular basis of cancer drug targets and the mechanisms of drug resistance. Our objective is to gather a comprehensive collection of at least 10 articles, with the potential for the Special Issue to be printed in book form if this number is achieved.

In this Special Issue, research areas may include the discovery and validation of novel molecular targets, elucidation of molecular mechanisms of intrinsic and acquired drug resistance, the role of tumor heterogeneity and the tumor microenvironment in resistance, strategies to overcome resistance, development of biomarkers for predicting response and resistance, and studies on new anti-cancer agents and resistance modulators.

We look forward to receiving your contributions.

Dr. Yuhao Xie
Prof. Dr. Concettina La Motta
Dr. Rakesh Kumar Srivastava
Guest Editors

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