Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Cell Organelles in Normal Aging, Senescence, and Cancer
edited by and Christopher Albanese
submission deadline 20 Jan 2026 | Viewed by 498 | Submission Open
Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8
(This special issue belongs to the Section Cellular Aging)
Study on Human Mesenchymal Stem Cells—2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 308 | Submission Open
Keywords: mesenchymal stem cells; disease; cardiac; therapy
(This special issue belongs to the Section Stem Cells)
Cellular Origin of Glioma: From Triggers to Treatments
edited by Katherine Karakoula
submission deadline 20 Jan 2026 | Viewed by 298 | Submission Open
Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells
Intestinal Stem Cells submission deadline 20 Jan 2026 | Viewed by 149 | Submission Open
Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt
(This special issue belongs to the Section Stem Cells)
The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead submission deadline 20 Jan 2026 | Viewed by 138 | Submission Open
Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO
Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting
edited by
submission deadline 20 Jan 2026 | Viewed by 100 | Submission Open
Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment
Molecular Basis of Gynecological Disorders and Associated Infertility submission deadline 20 Jan 2026 | Viewed by 82 | Submission Open
Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies
(This special issue belongs to the Section Cellular Pathology)
Fibrosis in Chronic Inflammatory Diseases submission deadline 25 Jan 2026 | 8 articles | Viewed by 15771 | Submission Open
Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets
(This special issue belongs to the Section Cellular Pathology)
Targeting Hallmarks of Cancer submission deadline 25 Jan 2026 | 3 articles | Viewed by 5725 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease submission deadline 25 Jan 2026 | 1 articles | Viewed by 782 | Submission Open
Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health
(This special issue belongs to the Section Cell Signaling)
The Role of T Cells in Type 1 Diabetes submission deadline 25 Jan 2026 | Viewed by 500 | Submission Open
Keywords: T cells; inflammation; T cell receptor; type 1 diabetes
(This special issue belongs to the Section Cellular Immunology)
Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies
edited by
submission deadline 25 Jan 2026 | Viewed by 155 | Submission Open
Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies
(This special issue belongs to the Section Cellular Immunology)
Targeting Immune Dysfunction in Aging and Age-Related Diseases
edited by and
submission deadline 25 Jan 2026 | Viewed by 148 | Submission Open
Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions
Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread
edited by Erica Pranzini
submission deadline 25 Jan 2026 | Viewed by 143 | Submission Open
Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism
Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms
edited by Masmoudi-Kouki Olfa and
submission deadline 25 Jan 2026 | Viewed by 121 | Submission Open
Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling
(This special issue belongs to the Section Stem Cells)
Plant Stress and Acclimation Responses During Global Warming submission deadline 25 Jan 2026 | Viewed by 105 | Submission Open
Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches
edited by
submission deadline 25 Jan 2026 | Viewed by 74 | Submission Open
Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics
(This special issue belongs to the Section Stem Cells)
The Developments and Applications of Vibrational Spectroscopy in Cellular Research
edited by
submission deadline 25 Jan 2026 | Viewed by 63 | Submission Open
Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging
(This special issue belongs to the Section Cell Methods)
Insights into the Pathophysiology of NeuroCOVID: Current Topics submission deadline 26 Jan 2026 | 1 articles | Viewed by 1136 | Submission Open
Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases
(This special issue belongs to the Section Cellular Pathology)
Neuronal Development and Disease: From Molecular Bases to Neurological Disorders
edited by Ramiro Almeida
submission deadline 30 Jan 2026 | 4 articles | Viewed by 4483 | Submission Open
Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg
edited by and Edie Goldsmith
submission deadline 30 Jan 2026 | 4 articles | Viewed by 3110 | Submission Open
Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering
(This special issue belongs to the Section Cell Microenvironment)
Mechanisms Underlying Cardiovascular Aging
edited by Soheil Saeedi
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2668 | Submission Open
Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies
(This special issue belongs to the Section Cells of the Cardiovascular System)
Tumor Immune Responsiveness in the Era of T Cell Immunotherapy
edited by and
submission deadline 30 Jan 2026 | Viewed by 166 | Submission Open
Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation
Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders
edited by Walid Shaalan, Benedikt Schaefgen and
submission deadline 30 Jan 2026 | Viewed by 118 | Submission Open
Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling
(This special issue belongs to the Section Stem Cells)
Ubiquitin Ligases in Health and Diseases
edited by Haitao Luan
submission deadline 30 Jan 2026 | Viewed by 88 | Submission Open
Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting
(This special issue belongs to the Section Cell Signaling)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2026 | 8 articles | Viewed by 20211 | Submission Open
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2026 | 6 articles | Viewed by 17472 | Submission Open
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cancer-Associated Fibroblasts: Challenges and Directions submission deadline 31 Jan 2026 | 4 articles | Viewed by 13623 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Imaging Methods in Cell Biology submission deadline 31 Jan 2026 | 6 articles | Viewed by 13611 | Submission Open
Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology
(This special issue belongs to the Section Cell Methods)
Neuroinflammation in Brain Health and Diseases
edited by Debashis Dutta and Nemil Bhatt
submission deadline 31 Jan 2026 | 8 articles | Viewed by 11068 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
(This special issue belongs to the Section Cells of the Nervous System)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 31 Jan 2026 | 3 articles | Viewed by 5748 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Renewing Reasons to Believe in Gene Therapies for Epilepsy
edited by Casper Gøtzsche
submission deadline 31 Jan 2026 | 2 articles | Viewed by 5196 | Submission Open
Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need
(This special issue belongs to the Section Cells of the Nervous System)
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Jan 2026 | 2 articles | Viewed by 2031 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1733 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
New Advances in Tissue Engineering and Regeneration submission deadline 31 Jan 2026 | 1 articles | Viewed by 1495 | Submission Open
Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research
(This special issue belongs to the Section Tissues and Organs)
Cell Behavior Under Blood Flow
edited by Alexander Gural, Ivana Pajic-Lijakovic and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1050 | Submission Open
Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress
The Role of Macrophages in Leishmaniasis: Current Perspective
edited by Devki Nandan
submission deadline 31 Jan 2026 | 1 articles | Viewed by 764 | Submission Open
Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions
Single-Molecule Tracking for Live Cells
edited by
submission deadline 31 Jan 2026 | Viewed by 309 | Submission Open
Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory
Mechanisms That Link Olfactory Perception with Aging in Drosophila
edited by , Anindya Ganguly and Jordan A. Munroe
submission deadline 31 Jan 2026 | Viewed by 274 | Submission Open
Keywords: olfaction; aging; neuroscience
(This special issue belongs to the Section Cellular Aging)
Diagnostic and Therapeutic Application of Extracellular Vesicles (EV) submission deadline 31 Jan 2026 | Viewed by 266 | Submission Open
Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications
Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
edited by Valeria Gerbino
submission deadline 31 Jan 2026 | Viewed by 195 | Submission Open
Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies
(This special issue belongs to the Section Cells of the Nervous System)
Human Organoids: A New Frontier in Disease Modeling
edited by and Umesh Kumar
submission deadline 31 Jan 2026 | Viewed by 167 | Submission Open
Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms in Immune Regulation—Second Edition
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 31 Jan 2026 | Viewed by 163 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Gastrointestinal Disorders: Immunity and Inflammation
edited by Faizan Ahmed and
submission deadline 31 Jan 2026 | Viewed by 147 | Submission Open
Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways
Genetics and Gene Regulation
edited by and
submission deadline 31 Jan 2026 | Viewed by 134 | Submission Open
Keywords: genetics; gene regulation; human diseases
Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
edited by and Benjamin Wolozin
submission deadline 31 Jan 2026 | Viewed by 131 | Submission Open
Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
New Trends and Advances in Molecular Targeted Therapy for Cancers
edited by Dhivya Sridaran and
submission deadline 31 Jan 2026 | Viewed by 119 | Submission Open
Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies
(This special issue belongs to the Section Cell and Gene Therapy)
New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response
edited by
submission deadline 31 Jan 2026 | Viewed by 118 | Submission Open
Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors
Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities
edited by Fabio Guolo
submission deadline 31 Jan 2026 | Viewed by 109 | Submission Open
Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers
(This special issue belongs to the Section Cellular Immunology)
Examining the Cellular Biology of Adenovirus
edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard
submission deadline 31 Jan 2026 | Viewed by 103 | Submission Open
Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome
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