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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 15 Nov 2025 | Viewed by 1456 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Novel Therapies and Biomarkers for Rare Diseases

edited by Reena Kartha

submission deadline 15 Nov 2025 | Viewed by 137 | Submission Open

Keywords: rare diseases; translational research; novel therapies; biomarker discovery; precision medicine

The Role of Integrins and Small GTPases in Health and Disease

edited by

Tione Buranda

submission deadline 15 Nov 2025 | Viewed by 32 | Submission Open

Keywords: cell signaling; integrins; cell adhesion; integrins diseases; infectious diseases

Lipids and Lipidomics in Neurodegenerative Diseases

edited by

Nathalie Bernoud-Hubac

and Catherine Malaplate

submission deadline 20 Nov 2025 | 1 articles | Viewed by 7944 | Submission Open

Keywords: lipids; lipidomics; neurodegenerative disease diagnosis; prevention; or treatment; cellular and molecular mechanisms

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Advances in Prenatal Exposure to Environmental Toxicants

edited by

Douglas M. Ruden

and

Sudipta Dutta

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7516 | Submission Open

Keywords: prenatal exposures; toxicogenomics; epigenomics; placenta; perinatal outcomes; neurodevelopmental outcomes; respiratory outcomes

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3225 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3036 | Submission Open

Keywords: adipocyte differentiation; progenitors; and stem cells; adipokines; myokines; hepatokines; cytokines; cellular signaling; and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics; genomics; metabolomics; other ‘ omics’ technologies; metabolic syndrome; obesity; insulin resistance; cancer

(This special issue belongs to the Section Tissues and Organs)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 20 Nov 2025 | Viewed by 406 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

Aging and Metabolic Diseases

edited by

Carlos Guillen

submission deadline 20 Nov 2025 | Viewed by 402 | Submission Open

Keywords: aging; insulin resistance; diabetes; obesity; mitochondrial dysfunction; beta-galactosidase; senescent-associated secretory phenotype; pancreatic beta cells

(This special issue belongs to the Section Cellular Aging)

Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease

edited by

Kay-Dietrich Wagner

submission deadline 20 Nov 2025 | 1 articles | Viewed by 334 | Submission Open

Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 20 Nov 2025 | Viewed by 318 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Extracellular Vesicles Based Drug Delivery

edited by

Giovanni Camussi

and

Cristina Grange

submission deadline 20 Nov 2025 | Viewed by 265 | Submission Open

Keywords: EV engineering; targeting; therapy; natural carrier; exosomes

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 20 Nov 2025 | Viewed by 160 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cells of the Nervous System)

Epigenetic Regulation in Plant–Microbe Interactions and Environmental Adaptation

edited by Zhongshou Wu and Bochen Jiang

submission deadline 20 Nov 2025 | Viewed by 130 | Submission Open

Keywords: epigenetic regulation; plant– microbe interactions; environmental adaptation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Acute Liver Failure: Molecular Actors in Liver–Adipose Tissue Interplay

edited by Marika Crescenzi

submission deadline 20 Nov 2025 | Viewed by 104 | Submission Open

Keywords: inflammasome; adipose tissue; acute liver injury; adipokines; liver macrophages; hepatic stellate cells; liver sinusoidal endothelial cells

(This special issue belongs to the Section Tissues and Organs)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 20 Nov 2025 | Viewed by 65 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

New Insights into Astrocytes in Health and Disease

edited by

Tao Tao

submission deadline 20 Nov 2025 | Viewed by 59 | Submission Open

Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response

(This special issue belongs to the Section Cells of the Nervous System)

Genetic and Genomic Insights into Complex Human Diseases: Advances, Challenges and Integrative Approaches

edited by Tianxiao Huan and Chan Zhou

submission deadline 20 Nov 2025 | Viewed by 55 | Submission Open

Keywords: genetics; genomics; proteomics; complex diseases; multi-omics; machine learning

Atherosclerosis and Thrombosis: Molecular and Pathological Research Advance

edited by

Tijana Subotički

Olivera Mitrović Ajtić

and

Vladan P. Čokić

submission deadline 20 Nov 2025 | Viewed by 45 | Submission Open

Keywords: atherosclerosis; thrombosis; molecular mechanisms; translational research; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Nov 2025 | Viewed by 44 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

The Metabolic Interactions and Pathways in Cancers

edited by Mohamed Elgendy

submission deadline 20 Nov 2025 | Viewed by 37 | Submission Open

Keywords: cancer metabolism; metastasis; drug resistance; oncometabolites; metabolic plasticity; diet; bioenergetics; metabolic crosstalk; immunotherapy

Targeting Tumor Metabolism and Epigenetics: Mechanisms and Therapeutic Strategies

edited by

Jorge Mata-Garrido

Raquel Francés

and Íñigo Casafont

submission deadline 22 Nov 2025 | Viewed by 169 | Submission Open

Keywords: tumor metabolism; epigenetics; metabolic reprogramming; DNA methylation; histone modification; warburg effect; glycolysis inhibitors; fatty acid synthesis; chromatin remodeling; cancer therapy

(This special issue belongs to the Section Cellular Metabolism)

Cellular and Molecular Basis in Chronic Kidney Disease

edited by

Prabhatchandra Dube

submission deadline 25 Nov 2025 | 8 articles | Viewed by 15801 | Submission Open

Keywords: CKD; renal inflammation; renal fibrosis; RAAS; aldosterone; TGF-B1; uremic toxins; hypertension; GFR; albuminuria

(This special issue belongs to the Section Cellular Pathology)

Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities

edited by

Vasily M. Studitsky

submission deadline 25 Nov 2025 | 4 articles | Viewed by 7161 | Submission Open

Keywords: DNA damage; DNA repair; epigenetics; chromatin; remodeling

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Glial Cells in Aging Neuroscience

edited by

Renato Socodato

submission deadline 25 Nov 2025 | 1 articles | Viewed by 3904 | Submission Open

Keywords: glial cells; aging; neuroinflammation; neurodegeneration; glial– neuronal interactions; glial– glial crosstalk; astrocytes; oligodendrocytes; microglia; ependymal cells

(This special issue belongs to the Section Cellular Aging)

Biomolecular Condensates in Oncology and Immunology

edited by

Andrzej Mackiewicz

Pravin B. Sehgal

and

Mariusz Kaczmarek

submission deadline 25 Nov 2025 | 1 articles | Viewed by 844 | Submission Open

Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis

(This special issue belongs to the Section Cellular Immunology)

Cell Signaling in Neurodegeneration Disease

edited by

Rijwan Uddin Ahammad

, Yasuhiro Funahashi,

Akira Sobue

Xinjian Zhang

and Md-nadim Hossain

submission deadline 25 Nov 2025 | Viewed by 113 | Submission Open

Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience

(This special issue belongs to the Section Cells of the Nervous System)

CAR T Cells in Human Cancers

edited by

Tabish H. Khan

and

Naoshad Muhammad

submission deadline 25 Nov 2025 | Viewed by 77 | Submission Open

Keywords: CAR T cells; engineered immune cell therapies; CAR T cell engineering

Pathology and Treatments of Amyotrophic Lateral Sclerosis (ALS)

edited by Laxman Gangwani

submission deadline 28 Nov 2025 | 1 articles | Viewed by 351 | Submission Open

Keywords: amyotrophic lateral sclerosis (ALS); pathology; molecular mechanisms; treatments; symptom management; biological mechanisms; risk factors; innovative treatments

(This special issue belongs to the Section Cellular Pathology)

Cellular Senescence and Senotherapies in the Aging Retina

edited by

Bhavana Chhunchha

submission deadline 28 Nov 2025 | Viewed by 273 | Submission Open

Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Cellular Aging)

Cell-to-Cell Crosstalk as a Target of Therapies

edited by

Agnieszka Gizak

and

Dominika Drulis-Fajdasz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 6742 | Submission Open

Keywords: cell-to-cell crosstalk; cellular communication; microenvironment; extracellular vesicles; diagnostic tools; membrane nanotubes; pathogenesis; therapy; cell metabolism; homeostasis

(This special issue belongs to the Section Cell Microenvironment)

Recent Advances in Metabolism and Oxidative Stress in Human Diseases 2.0

edited by

Isabella Panfoli

and Vanessa Cossu

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4132 | Submission Open

Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism

(This special issue belongs to the Section Cellular Metabolism)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3997 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer

edited by Sumit Sen Santara,

Engin Berber

, Weshely Kujur and Sachin Mulik

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3322 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Advances in Muscle Research in Health and Disease—2nd Edition

edited by

Wan Lee

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3155 | Submission Open

Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target

(This special issue belongs to the Section Tissues and Organs)

Gastrointestinal Cancer: From Cellular and Molecular Mechanisms to Therapeutic Opportunities

edited by

Federica Laudisi

and

Carmine Stolfi

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2980 | Submission Open

Keywords: colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; tumor microenvironment; cytokines; epigenetic; checkpoint inhibitors; biomarkers; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition

edited by

Dimitrios Kouroupis

and

Thomas M. Best

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2715 | Submission Open

Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering

(This special issue belongs to the Section Stem Cells)

Cellular Mechanisms in Mitochondrial Function and Calcium Signaling

edited by Sergio De la Fuente and Jaime Santo-Domingo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1924 | Submission Open

Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling

(This special issue belongs to the Section Cellular Metabolism)

Molecular and Cellular Research on Spinal Cord Injury

edited by

Vinnitsa Buzoianu-Anguiano

and

Jörg Mey

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1881 | Submission Open

Keywords: spinal cord injury; growth inhibitory factors; axonal regeneration; neuroprotection; combined therapies; cell trasnplants; regenerative medicine; inhibition scar formation; extracellular matrix molecules

(This special issue belongs to the Section Cellular Pathology)

Neuroinflammation in Developmental Brain Diseases

edited by

Evelyne Gozal

Jun Cai

and

Gregory Neal Barnes

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1656 | Submission Open

Keywords: neuroinflammation; endothelial injury; blood brain barrier; microglia; immune dysfunction; oxidative stress; autism spectrum disorders; epilepsy; cerebral palsy; schizophrenia; neurodevelopment; neurovascular brain signaling; inflammatory cytokines; immune cells

(This special issue belongs to the Section Cells of the Nervous System)

Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions

edited by

Nongthombam Boby

and Susanta Pahari

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1238 | Submission Open

Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use

(This special issue belongs to the Section Cellular Immunology)

Aging and Neurodegeneration: Molecular Insights and Emerging Strategies

edited by

Piotr Paweł Chmielewski

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1181 | Submission Open

Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research

(This special issue belongs to the Section Cellular Aging)

Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research

edited by

Elena Coccia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1166 | Submission Open

Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine

(This special issue belongs to the Section Stem Cells)

Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells

edited by

Federica Facchin

and

Silvia Canaider

submission deadline 30 Nov 2025 | Viewed by 1115 | Submission Open

Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine

(This special issue belongs to the Section Stem Cells)

Updates of Stem Cell Applications in Bone Tissue Engineering

edited by Fahad Karim Kidwai

submission deadline 30 Nov 2025 | 1 articles | Viewed by 979 | Submission Open

Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells

(This special issue belongs to the Section Stem Cells)

Genetic and Cellular Basis of Autoimmune Diseases

edited by

Christian Sadik

submission deadline 30 Nov 2025 | 1 articles | Viewed by 963 | Submission Open

Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression

edited by

Anand Singh

and Sudheer Kumar Gara

submission deadline 30 Nov 2025 | Viewed by 592 | Submission Open

Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling

(This special issue belongs to the Section Cellular Pathology)

G Protein-Coupled Receptors and Diseases

edited by

Yongqiang Chen

submission deadline 30 Nov 2025 | Viewed by 436 | Submission Open

Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation

Role of Calpains in Health and Diseases

edited by

Michel Baudry

and Peter A. Greer

submission deadline 30 Nov 2025 | Viewed by 384 | Submission Open

Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor

(This special issue belongs to the Section Cellular Pathology)

Hypoxia Pathway Proteins in the Immune System: Regulation, Disease, and Therapeutics

edited by Ben Wielockx

submission deadline 30 Nov 2025 | Viewed by 319 | Submission Open

Keywords: hypoxia; oxygen sensors; immune system; HIF; disease mechanisms; therapeutics; inflammation; autoimmunity; cancer immunology

(This special issue belongs to the Section Cellular Immunology)

Displaying special issue 251-300 on page 6 of 11.

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