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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Cell Organelles in Normal Aging, Senescence, and Cancer

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 20 Jan 2026 | Viewed by 498 | Submission Open

Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8

(This special issue belongs to the Section Cellular Aging)

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 20 Jan 2026 | Viewed by 308 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

Cellular Origin of Glioma: From Triggers to Treatments

edited by Katherine Karakoula

submission deadline 20 Jan 2026 | Viewed by 298 | Submission Open

Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 20 Jan 2026 | Viewed by 149 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 20 Jan 2026 | Viewed by 138 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 20 Jan 2026 | Viewed by 100 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 20 Jan 2026 | Viewed by 82 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Jan 2026 | 8 articles | Viewed by 15771 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | 3 articles | Viewed by 5725 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

Soluble Interleukin-6 Receptor (sIL-6R): Role in Health and Disease

edited by

Rebecca Aicheler

and

Richard Webb

submission deadline 25 Jan 2026 | 1 articles | Viewed by 782 | Submission Open

Keywords: sIL-6R; IL-6 signalling; IL-6ST; genetic polymorphism; health; disease; exercise physiology; therapeutics; mental health

(This special issue belongs to the Section Cell Signaling)

The Role of T Cells in Type 1 Diabetes

edited by

Ismail Syed

and

Mayur S. Parmar

submission deadline 25 Jan 2026 | Viewed by 500 | Submission Open

Keywords: T cells; inflammation; T cell receptor; type 1 diabetes

(This special issue belongs to the Section Cellular Immunology)

Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 25 Jan 2026 | Viewed by 155 | Submission Open

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Targeting Immune Dysfunction in Aging and Age-Related Diseases

edited by

Anna Aiello

and

Anna Calabrò

submission deadline 25 Jan 2026 | Viewed by 148 | Submission Open

Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions

Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread

edited by Erica Pranzini

submission deadline 25 Jan 2026 | Viewed by 143 | Submission Open

Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Jan 2026 | Viewed by 121 | Submission Open

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

Plant Stress and Acclimation Responses During Global Warming

edited by

Stanisław Karpiński

submission deadline 25 Jan 2026 | Viewed by 105 | Submission Open

Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches

edited by

Luigi Racioppi

submission deadline 25 Jan 2026 | Viewed by 74 | Submission Open

Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics

(This special issue belongs to the Section Stem Cells)

The Developments and Applications of Vibrational Spectroscopy in Cellular Research

edited by

Maria Lasalvia

submission deadline 25 Jan 2026 | Viewed by 63 | Submission Open

Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging

(This special issue belongs to the Section Cell Methods)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 26 Jan 2026 | 1 articles | Viewed by 1136 | Submission Open

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Neuronal Development and Disease: From Molecular Bases to Neurological Disorders

edited by Ramiro Almeida

submission deadline 30 Jan 2026 | 4 articles | Viewed by 4483 | Submission Open

Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity

(This special issue belongs to the Section Cells of the Nervous System)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 30 Jan 2026 | 4 articles | Viewed by 3110 | Submission Open

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2668 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 30 Jan 2026 | Viewed by 166 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Stem Cells, Disease Mechanisms, and Therapeutic Innovations in Breast and Endometrial Disorders

edited by Walid Shaalan, Benedikt Schaefgen and

Nourhan Hassan

submission deadline 30 Jan 2026 | Viewed by 118 | Submission Open

Keywords: endometrial stem cells; breast cancer; endometrial diseases; tumor microenvironment; matrix remodeling; regenerative medicine; bioengineering; stem cell therapy; molecular pathogenesis; disease modeling

(This special issue belongs to the Section Stem Cells)

Ubiquitin Ligases in Health and Diseases

edited by Haitao Luan

submission deadline 30 Jan 2026 | Viewed by 88 | Submission Open

Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting

(This special issue belongs to the Section Cell Signaling)

Advanced Technology for Cellular Imaging

edited by Alessandro Grinzato,

Vittoria Raimondi

and

J. Bernard Heymann

submission deadline 31 Jan 2026 | 8 articles | Viewed by 20211 | Submission Open

Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases

edited by

Prathapan Ayyappan

submission deadline 31 Jan 2026 | 6 articles | Viewed by 17472 | Submission Open

Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods

(This special issue belongs to the Section Cells of the Cardiovascular System)

Cancer-Associated Fibroblasts: Challenges and Directions

edited by

Paul J. Higgins

and

Ramesh Mukkamala

submission deadline 31 Jan 2026 | 4 articles | Viewed by 13623 | Submission Open

Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents

(This special issue belongs to the Section Cell Microenvironment)

Imaging Methods in Cell Biology

edited by

Claudia Moscheni

and

Nicoletta Gagliano

submission deadline 31 Jan 2026 | 6 articles | Viewed by 13611 | Submission Open

Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology

(This special issue belongs to the Section Cell Methods)

Neuroinflammation in Brain Health and Diseases

edited by Debashis Dutta and Nemil Bhatt

submission deadline 31 Jan 2026 | 8 articles | Viewed by 11068 | Submission Open

Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics

(This special issue belongs to the Section Cells of the Nervous System)

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5748 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Renewing Reasons to Believe in Gene Therapies for Epilepsy

edited by Casper Gøtzsche

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5196 | Submission Open

Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need

(This special issue belongs to the Section Cells of the Nervous System)

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2031 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases

edited by Patricia Morcillo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1733 | Submission Open

Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers

(This special issue belongs to the Section Cellular Aging)

New Advances in Tissue Engineering and Regeneration

edited by

Giorgia Borciani

and

Giorgia Montalbano

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1495 | Submission Open

Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research

(This special issue belongs to the Section Tissues and Organs)

Cell Behavior Under Blood Flow

edited by Alexander Gural, Ivana Pajic-Lijakovic and

Gregory Barshtein

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1050 | Submission Open

Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress

The Role of Macrophages in Leishmaniasis: Current Perspective

edited by Devki Nandan

submission deadline 31 Jan 2026 | 1 articles | Viewed by 764 | Submission Open

Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions

Single-Molecule Tracking for Live Cells

edited by

Zeno Földes-Papp

submission deadline 31 Jan 2026 | Viewed by 309 | Submission Open

Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory

Mechanisms That Link Olfactory Perception with Aging in Drosophila

edited by

Tuhin Subhra Chakraborty

, Anindya Ganguly and Jordan A. Munroe

submission deadline 31 Jan 2026 | Viewed by 274 | Submission Open

Keywords: olfaction; aging; neuroscience

(This special issue belongs to the Section Cellular Aging)

Diagnostic and Therapeutic Application of Extracellular Vesicles (EV)

edited by

Maria Magdalena Barreca

and

Chiara Corrado

submission deadline 31 Jan 2026 | Viewed by 266 | Submission Open

Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications

Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond

edited by Valeria Gerbino

submission deadline 31 Jan 2026 | Viewed by 195 | Submission Open

Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies

(This special issue belongs to the Section Cells of the Nervous System)

Human Organoids: A New Frontier in Disease Modeling

edited by

Priyanka Verma

and Umesh Kumar

submission deadline 31 Jan 2026 | Viewed by 167 | Submission Open

Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms in Immune Regulation—Second Edition

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 31 Jan 2026 | Viewed by 163 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Pathology)

Gastrointestinal Disorders: Immunity and Inflammation

edited by Faizan Ahmed and

Aditi Bhargava

submission deadline 31 Jan 2026 | Viewed by 147 | Submission Open

Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways

Genetics and Gene Regulation

edited by

Yujing Li

and

Han Yang

submission deadline 31 Jan 2026 | Viewed by 134 | Submission Open

Keywords: genetics; gene regulation; human diseases

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by

Paul D. Coleman

and Benjamin Wolozin

submission deadline 31 Jan 2026 | Viewed by 131 | Submission Open

Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

New Trends and Advances in Molecular Targeted Therapy for Cancers

edited by Dhivya Sridaran and

Jeremy M. Crook

submission deadline 31 Jan 2026 | Viewed by 119 | Submission Open

Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies

(This special issue belongs to the Section Cell and Gene Therapy)

New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response

edited by

Bernhard Ryffel

submission deadline 31 Jan 2026 | Viewed by 118 | Submission Open

Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors

Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities

edited by Fabio Guolo

submission deadline 31 Jan 2026 | Viewed by 109 | Submission Open

Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers

(This special issue belongs to the Section Cellular Immunology)

Examining the Cellular Biology of Adenovirus

edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard

submission deadline 31 Jan 2026 | Viewed by 103 | Submission Open

Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome

Displaying special issue 251-300 on page 6 of 13.

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