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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights

edited by

Edyta Maria Urbanska

and

Eric Santoni-Rugiu

submission deadline 31 Jul 2026 | Viewed by 271 | Submission Open

Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC; FISH; NGS); targeted therapy

Interactions Between Nanomaterials and Cells

edited by Ali Dinari and

Roger Schneiter

submission deadline 31 Jul 2026 | Viewed by 266 | Submission Open

Keywords: nanomaterial– cell interactions; nanomedicine; cellular uptake and trafficking; nano– bio interface; intracellular signaling; cellular stress and toxicity; stem cells and nanomaterials; advanced imaging and characterization

(This special issue belongs to the Section Cellular Biophysics)

Recent Insights into the Role of Metal Ions in the Nervous System

edited by Richard H. Dyck

submission deadline 31 Jul 2026 | Viewed by 261 | Submission Open

Keywords: metal ions; neurobiology; zinc signalling; copper homeostasis; iron metabolism; calcium signalling; magnesium; lithium; metallomics; synaptic transmission; neuromodulation; ion transporters; metal-binding proteins; oxidateive stress; mitochondrial function; neurodevelopment; synaptic plasticity; neuroinflammation; neurodegeneration; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; Alzheimer disease; Parkinson disease; imaging of metal ions; metal ion dysregulation

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis

edited by

Sandeep Rai Kaushik

, Pradeep Kumar Sheokand,

Nejat Düzgüneş

, Ekta Saini and Prashant Bajpai

submission deadline 31 Jul 2026 | Viewed by 259 | Submission Open

Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host– pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling

(This special issue belongs to the Section Cellular Immunology)

Advances in the Gut–Liver–Brain Axis in Human Health and Disease

edited by

Pradeep K. Shukla

submission deadline 31 Jul 2026 | Viewed by 245 | Submission Open

Keywords: gut– liver– brain axis; microbiota; liver metabolism; neuroinflammation; metabolic disease; neurodegeneration; gut– brain communication

Histological Classification of Lung Cells Across Animal Models and Life Stages

edited by

Roberta Ciccimarra

submission deadline 31 Jul 2026 | Viewed by 234 | Submission Open

Keywords: lung parenchyma; histological classification; normal lung anatomy; spatial organization; animal models; non-rodent models; comparative lung anatomy; lung ageing

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease

edited by

Prabhu Mathiyalagan

submission deadline 31 Jul 2026 | Viewed by 220 | Submission Open

Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy

Sex Differences in Molecular Mechanisms Linking Physiological Stress and Inflammation

edited by John R. Bethea and Kayla Lee Nguyen

submission deadline 31 Jul 2026 | Viewed by 215 | Submission Open

Keywords: ER stress; intracellular signaling; neuronal stress; immune activation; sex differences; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Tau-Targeted Treatment of Alzheimer’s Disease

edited by Amritpal Mudher, Katerina Papanikolopoulou, Lovesha Sivanantharajah and

Efthimios M. C. Skoulakis

submission deadline 31 Jul 2026 | Viewed by 213 | Submission Open

Keywords: tau protein; Alzheimer's disease; therapeutic targeting; tauopathy; neurodegeneration; disease models; drug discovery; protein aggregation

(This special issue belongs to the Section Cellular Neuroscience)

Molecular and Cellular Mechanisms of Pheochromocytoma and Paraganglioma

edited by

Mouna Tabebi

and

Oliver Gimm

submission deadline 31 Jul 2026 | Viewed by 209 | Submission Open

Keywords: pheochromocytoma; paraganglioma; tumor biology; molecular mechanisms; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Signaling Dynamics in Cancer

edited by Claudia Voena, Riccardo Taulli and Francesca Bersani

submission deadline 31 Jul 2026 | Viewed by 196 | Submission Open

Keywords: cancer signaling; cancer biology; tumor microenvironment; tumor progression; biomarkers; therapeutics

(This special issue belongs to the Section Cell Signaling)

Advances in Maternal–Fetal Immunity

edited by

Jun Lei

submission deadline 31 Jul 2026 | Viewed by 194 | Submission Open

Keywords: maternal– fetal immunity; developmental immunoregulation; pregnancy immune plasticity; fetal programming; pregnancy immunology

(This special issue belongs to the Section Reproductive Cells and Development)

Recent Advances in Vitamin D and K in Cancer

edited by

Alexandra M. Crǎciun

Ciprian N. Silaghi

and

Andreea Crintea

submission deadline 31 Jul 2026 | Viewed by 192 | Submission Open

Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance

AI and Multi-Modal Data Integration in Neurobiology and Neurological Diseases

edited by Jeon Lee

submission deadline 31 Jul 2026 | Viewed by 191 | Submission Open

Keywords: artificial intelligence; multi-modal integration; multi-omics; neurobiology; neurological disease; molecular characterization; neuronal biomarker; cellular pathway

(This special issue belongs to the Section Cellular Neuroscience)

Endothelial Phenotype Transition and Vascular Calcification Mechanisms

edited by

Yin Tintut

and Jeffrey J. Hsu

submission deadline 31 Jul 2026 | Viewed by 190 | Submission Open

Keywords: endothelial cell; vascular calcification; cell plasticity; endothelial-to-mesenchymal transition (EndMT); vascular biology

Uncovering Placental Inflammatory Pathways Affecting the Developing Brain

edited by

Guillaume Sébire

and

Math Chevin

submission deadline 31 Jul 2026 | Viewed by 179 | Submission Open

Keywords: neuroplacentology; neuroinflammation; hypoxia– ischemia; developing brain; ASD; CP; ADHD; learning disabilities; preclinical model; cell culture

(This special issue belongs to the Section Reproductive Cells and Development)

Molecular Drivers of Oncogenesis and Tumor Evolution: Mechanisms and Cellular Pathways

edited by

Ioana Berindan-Neagoe

and

Alexandru Tirpe

submission deadline 31 Jul 2026 | Viewed by 169 | Submission Open

Keywords: oncogenesis; cancer progression; cancer biology; tumor immunology; tumor microenvironment; metastasis; angiogenesis; metabolic reprogramming; therapy resistance

Plant Organelle Biology: Dynamics, Communication, and Metabolism

edited by

Alessio Papini

and

Giovanni Stefano

submission deadline 31 Jul 2026 | Viewed by 158 | Submission Open

Keywords: plant organelles; organelle dynamics; organelle communication; organelle metabolism; chloroplasts; mitochondria; peroxisomes; organelle signaling; cellular homeostasis; inter-organelle interactions; plant cell biology; organelle biogenesis; organelle degradation; plant stress responses

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Emerging Trends in Cell Therapy for Immune Complications Associated with Hematopoietic Cell Transplantation

edited by

Biki Gupta

and

Shiva Pathak

submission deadline 31 Jul 2026 | Viewed by 152 | Submission Open

Keywords: graft-versus-host disease; transplantation tolerance; immune cell therapy; hematopoietic cell transplantation; regulatory T cells

(This special issue belongs to the Section Cell and Gene Therapy)

Immune Cell Plasticity and Dysfunction in Hepatocellular Carcinoma and Viral Hepatitis

edited by

Carolina Boni

submission deadline 31 Jul 2026 | Viewed by 149 | Submission Open

Keywords: T cell exhaustion; chronic infection; anti-tumor immune response; hepatocellular carcinoma; tumor-infiltrating CD8+; T-cell subpopulations; immunometabolism; tumor microenvironment

(This special issue belongs to the Section Cellular Immunology)

Reprogramming Myeloid Cells: From Epigenetic Mechanisms to Therapeutic Applications in Inflammation and Disease

edited by Liwu Li

submission deadline 31 Jul 2026 | Viewed by 136 | Submission Open

Keywords: myeloid cell reprogramming; epigenetic regulation; inflammation; macrophage polarization; innate immune; monocyte; neutrophils

NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets

edited by Gaetano Spinelli and

Francesco Di Blasi

submission deadline 1 Aug 2026 | Viewed by 302 | Submission Open

Keywords: NF-κ B signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development

Stem Cells in Congenital Heart Disease: Novel Approaches and Regenerative Strategies

edited by

Aaron D. Argall

Mingtao Zhao

and Wei Shi

submission deadline 1 Aug 2026 | Viewed by 252 | Submission Open

Keywords: stem cell; congenital heart defect; iPSC; maturation; regeneration; cardiac arrhythmia; heart failure

(This special issue belongs to the Section Stem Cells)

Inflammation at the Nexus of Neurodegeneration: Cellular Mechanisms, Biomarkers and Therapeutic Targets

edited by Kirstan A. Vessey

submission deadline 1 Aug 2026 | Viewed by 205 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; neurovascular unit; inflammasome; cytokine signaling; cell death pathways; biomarkers; retinal degeneration; neurodegenerative disease

(This special issue belongs to the Section Cellular Neuroscience)

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 5 Aug 2026 | Viewed by 391 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

Focus on Machinery of Cell Death

edited by

Subhadip Mukhopadhyay

, Prashanta Kumar Panda and

Suprabhat Mukherjee

submission deadline 10 Aug 2026 | 8 articles | Viewed by 25413 | Submission Open

Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy

(This special issue belongs to the Section Cellular Pathology)

Ischemic Heart Disease: From Cellular Level to Clinical Approaches

edited by

Stefan A. Juričić

and

Milan R. Dobrić

submission deadline 10 Aug 2026 | 2 articles | Viewed by 4293 | Submission Open

Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy

The Role of Stem Cells in Retinal Conditions

edited by

Georgios Panos

, Theo Empeslidis and Lorenzo Motta

submission deadline 10 Aug 2026 | 2 articles | Viewed by 3566 | Submission Open

Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials

(This special issue belongs to the Section Stem Cells)

Cell Therapies in Cancer Treatment

edited by

Giovanni Amabile

submission deadline 10 Aug 2026 | 1 articles | Viewed by 3326 | Submission Open

Keywords: cellular therapies; cancer; immune

Remyelination: From Molecular Mechanism to Therapy

edited by

Antonella Ragnini-Wilson

and

Gaetano Barbato

submission deadline 10 Aug 2026 | 1 articles | Viewed by 1276 | Submission Open

Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration

Study on Ovarian Follicle Development

edited by Cecily V. Bishop and Jessica Cristina Lemos Motta

submission deadline 10 Aug 2026 | Viewed by 301 | Submission Open

Keywords: follicular development; ovarian follicle activation; ovarian reserve; in vitro follicle culture; translational reproductive biology

Cellular and Molecular Pathophysiology of Inflammatory Bowel Disease

edited by Atsushi Nishida

submission deadline 10 Aug 2026 | Viewed by 203 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; molecular mechanisms; mucosal immunology; intestinal epithelial barrier; host-microbiome interactions; cytokine signaling; translational research; precision medicine

(This special issue belongs to the Section Cellular Pathology)

Endothelial Dysfunction in Vascular Diseases

edited by Antonio Nesci

submission deadline 11 Aug 2026 | 2 articles | Viewed by 3290 | Submission Open

Keywords: endothelial dysfunction; vascular diseases; atherosclerosis; oxidative stress; nitric oxide; hypertension; vascular inflammation; endothelial repair

α-Synuclein in Parkinson’s Disease

edited by

Maria Ilenia De Bartolo

and

Matteo Costanzo

submission deadline 11 Aug 2026 | 2 articles | Viewed by 2896 | Submission Open

Keywords: α -synuclein; protein aggregation; neurodegeneration; Parkinson’ s disease; clinical subtypes; biomarkers; detection techniques; disease heterogeneity; prognostic stratification; translational neuroscience

Physics of Cancer: How Mechanobiology Drives Cancer Progression

edited by

Claudia Tanja Mierke

submission deadline 15 Aug 2026 | 1 articles | Viewed by 5215 | Submission Open

Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 15 Aug 2026 | 2 articles | Viewed by 2928 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Plant Stress and Acclimation Responses During Global Warming

edited by

Stanisław Karpiński

submission deadline 15 Aug 2026 | 1 articles | Viewed by 1746 | Submission Open

Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Genetics and Gene Regulation

edited by

Yujing Li

and

Han Yang

submission deadline 15 Aug 2026 | 1 articles | Viewed by 1488 | Submission Open

Keywords: genetics; gene regulation; human diseases

Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread

edited by Erica Pranzini

submission deadline 15 Aug 2026 | Viewed by 339 | Submission Open

Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism

Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches

edited by

Luigi Racioppi

submission deadline 15 Aug 2026 | Viewed by 276 | Submission Open

Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics

(This special issue belongs to the Section Stem Cells)

Advances in Osteosarcoma: Tumor Biology and Therapeutic Innovation

edited by

Eugenie S. Kleinerman

and

Pradeep Shrestha

submission deadline 15 Aug 2026 | Viewed by 261 | Submission Open

Keywords: osteosarcoma; immunotherapy; biomarker

(This special issue belongs to the Section Cellular Pathology)

Cellular Immunotherapies and Immune Modulation in Hematologic Cancers

edited by Erden Atilla and Ali Turan

submission deadline 15 Aug 2026 | Viewed by 181 | Submission Open

Keywords: cellular immunotherapy; CAR T; CAR NK; immune modulation; hematologic malignancies; microenvironment; cytokine biology; immune escape

(This special issue belongs to the Section Cellular Immunology)

Multipotent Mesenchymal Stromal Cells in the Tumor Microenvironment: Recent Advances and Emerging Concepts

edited by Yuri Petrenko

submission deadline 15 Aug 2026 | Viewed by 167 | Submission Open

Keywords: multipotent mesenchymal stromal cells; tumor microenvironment; cancer stem cells; metabolic rewiring; biomechanical cues; 3D modelling; paracrine interactions; vascularization; differentiation

(This special issue belongs to the Section Stem Cells)

Multi-Omics in the Cellular Microenvironment

edited by Emilio S. Rivera and Katerina Djambazova

submission deadline 15 Aug 2026 | Viewed by 160 | Submission Open

Keywords: cellular microenvironment; single-cell analysis; multi-omics; immunofluorescence microscopy; imaging mass spectrometry

(This special issue belongs to the Section Cell Methods)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 18 Aug 2026 | 2 articles | Viewed by 6084 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Aug 2026 | 3 articles | Viewed by 12012 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

Ageing and Neurodegenerative Diseases, Second Edition

edited by Feng Wang and

Antonella Caccamo

submission deadline 20 Aug 2026 | 3 articles | Viewed by 11496 | Submission Open

Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling

(This special issue belongs to the Section Cellular Pathology)

Role of Gene Regulation in Neurological Disorders

edited by

Yujing Li

and Yulin Jin

submission deadline 20 Aug 2026 | 3 articles | Viewed by 4650 | Submission Open

Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)

(This special issue belongs to the Section Cell and Gene Therapy)

Pathophysiology of Signal Transduction in Cardiovascular and Pulmonary Disease: 2nd Edition

edited by

Yung-Hsin Yeh

and

Ying-Ju Lai

submission deadline 20 Aug 2026 | 1 articles | Viewed by 3665 | Submission Open

Keywords: cardiac arrhythmia; atrium; ventricle; pulmonary; vascular; signal transduction

(This special issue belongs to the Section Cellular Pathology)

Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

edited by

Yuhao Xie

Concettina La Motta

and Rakesh Kumar Srivastava

submission deadline 20 Aug 2026 | 3 articles | Viewed by 3322 | Submission Open

Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers

Displaying special issue 251-300 on page 6 of 14.

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