Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
edited by Valeria Gerbino
submission deadline 31 Aug 2025 | Viewed by 106 | Submission Open
Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies
New Insights into Inflammasome: Mechanisms of Activation, Cell Death, and Diseases
edited by Ana Tapia-Abellán
submission deadline 31 Aug 2025 | Viewed by 81 | Submission Open
Keywords: inflammasomes; inflammation; pyroptosis; chronic diseases; autoinflammatory syndromes
(This special issue belongs to the Section Cellular Pathology)
Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease
edited by Praveen Koganti and
submission deadline 31 Aug 2025 | Viewed by 79 | Submission Open
Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway
The Role of Cellular Senescence in Health, Disease, and Aging
edited by
submission deadline 5 Sep 2025 | 7 articles | Viewed by 16575 | Submission Open
Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach
(This special issue belongs to the Section Cellular Aging)
Epigenetic Mechanisms of Tumorigenesis
edited by
submission deadline 10 Sep 2025 | Viewed by 321 | Submission Open
Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine
New Insights into Vascular Biology in Health and Disease
edited by Bashir M. Rezk
submission deadline 15 Sep 2025 | 4 articles | Viewed by 9966 | Submission Open
Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization
(This special issue belongs to the Section Cells of the Cardiovascular System)
Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer
edited by Emiko Mizoguchi
submission deadline 15 Sep 2025 | 4 articles | Viewed by 4827 | Submission Open
Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer
(This special issue belongs to the Section Cellular Pathology)
Molecular and Cellular Mechanisms of Marfan Syndrome submission deadline 15 Sep 2025 | 2 articles | Viewed by 1964 | Submission Open
Keywords: Marfan syndrome; aortic aneurysm; aortic dissection; TGFβ ; BMP; matrix metalloproteinase; NO synthase; mitochondrial dysfunction; oxidative stress; endothelium; aortic vascular smooth muscle cells; phenotypic switching; adventitia; hemodynamics; gene therapy; connective tissue disease
(This special issue belongs to the Section Cellular Pathology)
Advancements in Immunotherapy and CAR T Cell Therapy: Unleashing the Power of the Immune System Against Cancer
edited by
submission deadline 15 Sep 2025 | Viewed by 179 | Submission Open
Keywords: CAR T; immunotherapy; cancer; chimeric antigen receptors
(This special issue belongs to the Section Cellular Immunology)
In Vitro Model for Micro- and Nano-Technologies—Second Edition
edited by Tania Limongi
submission deadline 15 Sep 2025 | Viewed by 121 | Submission Open
Keywords: in vitro cell culture; micro- and nano-technology; extracellular vesicles; nanoparticles; quantum dots; biocompatibility; hemocompatibility; diagnosis; drug delivery; tissue engineering
(This special issue belongs to the Section Cellular Biophysics)
Cancer Cell Signaling, Autophagy and Tumorigenesis
edited by Debanjan Bhattacharya
submission deadline 15 Sep 2025 | Viewed by 50 | Submission Open
Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway
Molecular and Cellular Advances in Gut-Brain Axis
edited by and Radhakrishna Rao
submission deadline 20 Sep 2025 | 2 articles | Viewed by 19549 | Submission Open
Keywords: gut– brain axis; microbiome; omics; diet; biological sex; gender; early-life stress; immunity; mental health; neurodegenerative diseases; metabolic health
(This special issue belongs to the Section Cells of the Nervous System)
Advances in the Discovery of Retinal Degeneration submission deadline 20 Sep 2025 | 2 articles | Viewed by 1732 | Submission Open
Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood– retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology
(This special issue belongs to the Section Cellular Pathology)
Advances in Immunotherapy for Non-Small-Cell Lung Cancer
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1486 | Submission Open
Keywords: non-small cell lung cancer; immunotherapy; immune checkpoint inhibitors; PD-1; PD-L1; pembrolizumab; nivolumab; atezolizumab; CTLA4
(This special issue belongs to the Section Cellular Immunology)
Gene and Cellular Signaling Related to Muscle
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1354 | Submission Open
Keywords: skeletal muscle; molecular mechanism; muscle atrophy; therapeutics; metabolic signals; satellite cells
(This special issue belongs to the Section Cell Signaling)
Molecular Insights into Vascular Physiology and Pathology
edited by Suravi Majumder
submission deadline 20 Sep 2025 | Viewed by 238 | Submission Open
Keywords: vascular physiology; vascular pathology; endothelial cells; vascular smooth muscle cells; vascular inflammation; vascular signaling; vascular aging; vascular remodeling; atherosclerosis; cardiovascular diseases; biomarkers; novel therapeutic approaches
(This special issue belongs to the Section Cellular Pathology)
Macrophage-Epithelial Interplay in Pulmonary Fibrosis
edited by and Farhad Khosravi
submission deadline 20 Sep 2025 | Viewed by 208 | Submission Open
Keywords: macrophages; epithelial cells; idiopathic pulmonary fibrosis (IPF); immune response
Stem Cells and Endometrium
edited by Shiying Jin
submission deadline 20 Sep 2025 | Viewed by 70 | Submission Open
Keywords: stem cell; homeostasis; regeneration; endometrium
(This special issue belongs to the Section Stem Cells)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 20 Sep 2025 | Viewed by 69 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
Regulation of Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) in Angiogenesis
edited by Alessandra Loda and
submission deadline 25 Sep 2025 | 1 articles | Viewed by 1690 | Submission Open
Keywords: vascular endothelial growth factor (VEGF); VEGF receptors (VEGFRs); angiogenesis; endothelial cells; anti-angiogenic therapies; VEGFR inhibitors
Effective Embryo Maternal Interaction Support Favorable Pregnancy Outcome
edited by Eytan R. Barnea, and Guarano Alice
submission deadline 25 Sep 2025 | Viewed by 345 | Submission Open
Keywords: pregnancy; fertilization; tubal transport; embryogenesis; maternal quality control
(This special issue belongs to the Section Tissues and Organs)
Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease
edited by and Museer Ahmad Lone
submission deadline 25 Sep 2025 | Viewed by 331 | Submission Open
Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation
(This special issue belongs to the Section Cellular Biophysics)
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 25 Sep 2025 | Viewed by 317 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
(This special issue belongs to the Section Tissues and Organs)
Insights into the Pathophysiology of NeuroCOVID: Current Topics submission deadline 25 Sep 2025 | Viewed by 201 | Submission Open
Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases
(This special issue belongs to the Section Cellular Pathology)
Ovarian Microenvironment and Oocyte Quality: Mechanisms, Aging, and Therapeutic Strategies
edited by Haiyang Wang
submission deadline 25 Sep 2025 | Viewed by 68 | Submission Open
Keywords: ovarian microenvironment; oocyte; mechanisms; aging; therapeutic strategies
(This special issue belongs to the Section Cell Microenvironment)
Amyloid–Metal Interactions in Alzheimer’s Disease: Mechanisms, Biomarkers, and Therapeutic Advances
edited by
submission deadline 25 Sep 2025 | Viewed by 61 | Submission Open
Keywords: Alzheimer’ s; amyloids; Aß ; Tau; neurodegeneration; metal homeostasis; oxidative stress; neuropathology; PET
(This special issue belongs to the Section Cellular Aging)
Identifying Functional Genomics and Pathways in Cancer Pathogenesis and Therapy Resistance
edited by and Ramkrishna Mitra
submission deadline 25 Sep 2025 | Viewed by 49 | Submission Open
Keywords: functional genomics; cancer signaling pathways; targeted therapy; drug resistance; tumor microenvironment; oncogenomics; acquired resistance; tumor mutations
(This special issue belongs to the Section Cellular Pathology)
Cell Migration and Invasion
edited by Veronika Miskolci
submission deadline 28 Sep 2025 | Viewed by 115 | Submission Open
Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways
Potential of CAR-Based Cellular Immunotherapy for Non-oncologic Disorders submission deadline 30 Sep 2025 | 4 articles | Viewed by 17819 | Submission Open
Keywords: adoptive cell transfer; CAR-T cells; cell engineering; CAR products; CAR-T cell therapy; non-oncologic disorders; autoimmune diseases; cardiometabolic diseases; inflammatory organ fibrosis; senescent cell pathologies; infections
(This special issue belongs to the Section Cellular Immunology)
Unlocking the Secrets Behind Drug Resistance at the Cellular Level submission deadline 30 Sep 2025 | 3 articles | Viewed by 6837 | Submission Open
Keywords: molecular mechanisms; effective treatments; drug tests; bacterial resistance; chemoresistance
(This special issue belongs to the Section Cellular Immunology)
Onco-Hematology and Immunotherapy
edited by and Régis T. Costello
submission deadline 30 Sep 2025 | 2 articles | Viewed by 4488 | Submission Open
Keywords: immunotherapy; onco-hematology; CAR T cells; NK cells; immune system; immune cells; leukemias; lymphomas
(This special issue belongs to the Section Cellular Immunology)
Research on T Cells in Skin Inflammatory Disorders
edited by and Qing-Sheng Mi
submission deadline 30 Sep 2025 | 1 articles | Viewed by 4412 | Submission Open
Keywords: T cell; vitiligo; atopic dermatitis; T cell lymphoma
(This special issue belongs to the Section Cellular Immunology)
Eosinophils and Their Role in Allergy and Related Diseases
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3408 | Submission Open
Keywords: eosinophils; asthma; allergy; inflammation; anti-eosinophil biologics; interleukin-5; interleukin-5 receptor; degranulation; mediator release
(This special issue belongs to the Section Cellular Immunology)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 30 Sep 2025 | 1 articles | Viewed by 3373 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Molecular Therapeutic Advances for Neurodegenerative Diseases
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 2145 | Submission Open
Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders
(This special issue belongs to the Section Cellular Aging)
Control of Gene Expression by Co-Transcriptional Processes in Cell Homeostasis and Cell Fate Specification: Second Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1943 | Submission Open
Keywords: gene transcription; transcription elongation; RNA processing; RNA modification; RNA transport; lncRNA; histone modification; biomolecular condensates; diseases associated with dysregulation of gene regulation
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Autophagy and Tumor Microenvironment
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1846 | Submission Open
Keywords: autophagy; cancer growth; cancer therapy; chemoresistance; microenvironment
(This special issue belongs to the Section Autophagy)
Evolution, Structure, and Functions of Apolipoproteins L
edited by Etienne Pays
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1791 | Submission Open
Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation
Pathogenesis of Diabetic Kidney Disease
edited by Jia Fu
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1265 | Submission Open
Keywords: diabetic kidney disease (DKD); molecular mechanism; oxidative stress; chronic kidney disease; pathogenesis; diagnostic and therapeutic strategies; inflammation; metabolic dysfunction
(This special issue belongs to the Section Cellular Pathology)
Ras Family of Genes and Proteins: Structure, Function and Regulation
edited by , and Rosula Garcia-Navas
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1205 | Submission Open
Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF
Organellar Ca2+ Transport in Plant versus Animal Cells: Can We Learn from Each Other?
edited by Shey-Shing Sheu and Marc Freichel
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1102 | Submission Open
Keywords: organellar calcium transport; plant cells; animal cells; intracellular organelle communication; calcium signaling; mitochondria; organelle-targeted florescent Ca2+ indicators; super-resolution imaging
(This special issue belongs to the Section Cell Microenvironment)
Cell Biology: State of the Art and Perspectives in Italy 2025
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 928 | Submission Open
Keywords: cell biology; physiology; molecular biology
Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease
edited by Ki Ho Park
submission deadline 30 Sep 2025 | 1 articles | Viewed by 786 | Submission Open
Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management
edited by Luca Antonioli and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 711 | Submission Open
Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP
Sebaceous Gland in Skin Health and Disease
edited by and Monica Ottaviani
submission deadline 30 Sep 2025 | Viewed by 599 | Submission Open
Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms and Targeted Therapy of Acute Myeloid Leukemia
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 587 | Submission Open
Keywords: Acute Myeloid Leukemia (AML); molecular targets; gene therapy; drug resistance; targeted therapy; leukemia stem cells; oncogenic mutations; apoptosis; cell cycle regulation
(This special issue belongs to the Section Cellular Pathology)
CRISPR-Based Genome Editing in Translational Research—Third Edition
edited by , and Jifeng Zhang
submission deadline 30 Sep 2025 | 1 articles | Viewed by 522 | Submission Open
Keywords: genome; gene editing; CRISPR/Cas9
Retinoic Acid and Retinoid X Receptors - Series II submission deadline 30 Sep 2025 | Viewed by 388 | Submission Open
Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Contribution of Omics Sciences to Agricultural Biotechnology submission deadline 30 Sep 2025 | Viewed by 345 | Submission Open
Keywords: omics technologies; bioinformatics; systems biology; data mining; knowledge discovery; metabolic engineering; genetic engineering; plant biotechnologies; agrifoods; (a)biotic stress resilience; plant– microbe interactions
(This special issue belongs to the Section Cell Methods)
The Role of Epithelial Cells in Scleroderma—Second Edition
edited by Richard Stratton
submission deadline 30 Sep 2025 | Viewed by 286 | Submission Open
Keywords: fibrosis; epithelial– fibroblast interaction; EMT; cytokeratin 6 and 16
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