Molecular Mechanisms of Trophoblast Differentiation
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 August 2026 | Viewed by 880
Special Issue Editors
Interests: immunohistochemistry; cell culture; western blot analysis; gel electrophoresis; RNA isolation; RNA extraction; immunofluorescence; SDS-page; cell line culture; agarose gel electrophoresis
Interests: cancer biology; cancer genetics; endometriosis; pathology
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Special Issue Information
Dear Colleagues,
The placenta is a unique transient organ that forms during early pregnancy and plays a vital role in supporting fetal development and growth. Abnormal placentation can lead to various pregnancy complications—including miscarriage, preeclampsia, and intrauterine growth restriction—and may have lasting effects on the health of the offspring.
The successful development of the placenta depends on a finely regulated sequence of trophoblast cell differentiation. Recent advances have uncovered a complex network of molecular pathways, transcriptional programs, and epigenetic modifications that guide the formation and specialization of trophoblast lineages.
This Special Issue, entitled “Molecular Mechanisms of Trophoblast Differentiation”, aims to present new insights into the regulatory processes that govern trophoblast fate decisions, invasion, and interactions with maternal tissues. By integrating findings from model systems, human studies, and emerging technologies, the contributions in this issue will enhance our understanding of placental development and its relevance to maternal and fetal health, shedding light on both normal physiology and pregnancy-related disorders.
We warmly invite you to submit your latest original research articles or reviews to this Special Issue.
Dr. Milica Jovanović Krivokuća
Prof. Dr. Jianjun Wei
Guest Editors
Manuscript Submission Information
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Keywords
- trophoblast differentiation
- cytotrophoblast
- syncytiotrophoblast
- extravillous trophoblast
- trophoblast stem cells
- molecular mechanisms
- signaling pathways
- epigenetic regulation
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