Advances in CAR Cell Therapies and Manufacturing
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 August 2026 | Viewed by 1596
Special Issue Editors
Interests: upstream and downstream bio(pharmaceutical) processing, particularly for cell therapy products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This special issue will focus on CAR (Chimeric Antigen Receptor) cell therapies, highlighting recent advancements and manufacturing processes transforming cancer immunotherapy. The Issue will highlight new CAR types and important cell attributes such as the secretion of cytokines, granzymes etc. Different gene delivery strategies will be considered for introducing the CAR transgene into target cells, including viral methods employing lentiviral vectors and non-viral methods with or without the use of (nano)particle vectors. The Issue will cover developments in genetic editing techniques, including strategies like the use of CRISPR/Cas9 for precise modifications and knocking out genes to enhance cell function and persistence. Addressing the inherent patient-to-patient variability in the quantity and quality of collected cells for autologous products is also a crucial challenge. This Issue will explore efficient methods for expanding and cryopreserving CAR cell products, optimizing cell yield and quality while minimizing cost. This includes discussions on optimizing the cell expansion step for optimal growth and differentiation, and exploring scale-up approaches for allogeneic products. Lastly, it will discuss essential biomarkers and assays for evaluating the safety, efficacy, and functionality of CAR cell products. This includes exploring critical quality attributes like transduction efficiency, viability, purity, and advancements in real-time monitoring and in-line quality control technologies.
Prof. Dr. William J. Kelly
Dr. Madhuresh C. Sumit
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- CAR cells
- autologous
- allogeneic
- crispr
- lentivirus
- expansion
- cryopreservation
- isolation
- biomarker
- cytokines
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