Cellular Responses During Wound and Regeneration

Dear Colleagues,

Wound formation begins with tissue damage, often disrupting the epithelial barrier and deep tissues. This action causes blood vessel injury and triggers platelet-mediated clot formation to prevent further bleeding. This damage also initiates an inflammatory response, where neutrophils and macrophages rush to the site to clear pathogens and debris. Following this, wound regeneration begins with the proliferation phase, during which fibroblasts produce collagen and rebuild the extracellular matrix. Additionally, keratinocytes migrate to restore the skin surface, and angiogenesis generates new blood vessels to support tissue repair. Later stages of the healing process employ myofibroblasts to contract the wound and aid in tissue remodeling.

This Special Issue will highlight current knowledge in the field of wound healing and regeneration. Articles may include experimental research that elucidates cell signaling events under normal and diseased conditions (e.g., diabetes). Reviews and original research articles are welcome.

Dr. Eric A. Albrecht
Dr. Rebecca A. Wingert
Guest Editors

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