Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 September 2025 | Viewed by 30
Special Issue Editors
Interests: cell and molecular biology of single cells in Alzheimer’s and other neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Interests: examining the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis and Parkinson’s disease; the role of RNA binding proteins and translational regulation in disease processes
Special Issue Information
Dear Colleagues,
Stress granules are complex, dynamic, but underappreciated non-membranous components of cells. They respond to cellular stresses by forming and sequestering protein and nucleic acid molecules of the cell machinery in response to the imposed stress with the apparent aim of responding to the specific stress. Different stresses result in different profiles of sequestration. If the stress is withdrawn for any reason, the stress granules dissipate, but if the stress is chronic, as in Alzheimer's and other neurodegenerative diseases, the stress granules persist. In this Special Issue devoted to stress granules, we plan to deal with topics including, but not limited to, the detection of stress granules, where, when, under what circumstances, and in what cells stress granules are found, the structure of stress granules, mechanisms for the formation and dissolution of stress granules, the molecules sequestered by stress granules under different circumstances, the mechanisms by which stress granules modulate transcription and translation, stress granules, and proteostasis.
Prof. Dr. Paul D. Coleman
Prof. Dr. Benjamin Wolozin
Guest Editors
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Keywords
- stress granules
- Alzheimer's disease
- neurodegenerative diseases
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