Aging and Neurodegeneration: Molecular Insights and Emerging Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 175
Special Issue Editor
Interests: biogerontology; biomarkers; geroprotective strategies; inflammation; longevity; molecular mechanisms of neurodegeneration; neuroinflammation; therapeutic interventions
Special Issue Information
Dear Colleagues,
The World Health Organization predicts that by 2050, the number of adults affected by dementia will exceed 150 million globally. This growing prevalence underscores the urgent need for a deeper understanding of the molecular and cellular processes driving neurodegenerative conditions to inform the development of effective therapeutic interventions. Age is the primary risk factor for many neurodegenerative disorders, including Alzheimer’s disease, other dementias, and Parkinson’s disease. These conditions are associated with mechanisms such as impaired mitophagy, oxidative stress, molecular damage, endolysosomal dysfunction, chronic inflammation, and altered intercellular communication mediated by extracellular vesicles. These disruptions contribute to hallmark pathologies, including protein misfolding and aggregation (e.g., amyloid-beta peptide, tau protein, or alpha-synuclein), synaptic dysfunction, and ultimately neuronal loss. While these mechanisms are often studied in isolation, a growing body of evidence reveals that they are interconnected. Understanding these pathways provides opportunities to identify common molecular targets for the development of novel therapeutic strategies. In this Special Issue, we invite contributions that explore the fundamental molecular pathways underlying age-related neurodegeneration, innovative biomarkers for early diagnosis, and novel therapeutic approaches. Submissions focusing on translational research, which is indispensable for bridging the gap between bench and bedside, integrative strategies, and systematic reviews are particularly encouraged.
Dr. Piotr Paweł Chmielewski
Guest Editor
Manuscript Submission Information
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Keywords
- Alzheimer’s disease
- biomarkers
- endolysosomal pathway
- extracellular vesicles
- inflammation
- mitophagy
- neurodegeneration
- neuroinflammation
- Parkinson’s disease
- translational research
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