Molecular Mechanisms and Novel Therapeutics for Glioblastoma
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".
Deadline for manuscript submissions: 25 August 2026 | Viewed by 123
Special Issue Editors
Interests: molecular and cellular mechanisms of glioblastoma progression and therapeutic resistance; oncolytic virus therapy for malignant brain tumors; tumor–immune interactions and modulation of the tumor
Interests: oncolytic virotherapy and immune modulation in glioblastoma; tumor microenvironment-targeted therapeutics; cancer vaccine development for glioblastom; advanced in vivo modeling of glioblastoma; immune mechanisms governing tumor dormancy and metastasis
Special Issue Information
Dear Colleagues,
Glioblastoma remains one of the most aggressive and lethal primary brain tumors, with limited therapeutic options despite maximal surgical resection followed by radiotherapy and chemotherapy. The poor prognosis of this disease is largely driven by profound molecular heterogeneity, low antigen availability, and an immunosuppressive tumor microenvironment. In recent years, advances in molecular biology, tumor immunology, and translational neuroscience and omics technologies have provided new insights into the mechanisms underlying glioblastoma progression and treatment failure.
In parallel, innovative therapeutic strategies have emerged, including oncolytic virotherapy, cancer vaccines, cellular immunotherapies (TIL and CAR T cells), molecularly targeted agents, and rational combination strategies. In particular, oncolytic virotherapy has gained prominence for its dual ability to induce direct tumor cell lysis and to reprogram the tumor microenvironment through robust activation of anti-tumor immune responses. Translational research efforts have further enabled the development of locoregional and intratumoral therapeutic strategies, facilitating the transition from preclinical studies to early-phase clinical trials.
This Special Issue will provide a comprehensive overview of the molecular mechanisms of glioblastoma and highlight novel therapeutic approaches spanning basic, translational. We welcome original research articles and reviews addressing tumor biology, the tumor microenvironment, innovative treatment modalities, and integrated strategies that may shape the future of glioblastoma therapy.
Dr. Hirotaka Ito
Dr. Raziye Piranlioglu
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- glioblastoma
- molecular mechanisms
- oncolytic virus therapy
- immunotherapy
- tumor microenvironment
- translational research
- neurosurgery
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