Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 January 2026 | Viewed by 15
Special Issue Editor
Interests: acute myeloid leukemia; leukemia; hematological malignancies; clinical hematology
Special Issue Information
Dear Colleagues,
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal proliferation of undifferentiated myeloid precursors in bone marrow, leading to impaired hematopoiesis and rapid disease progression. Despite advances in molecular diagnostics and targeted therapies, AML remains associated with high morbidity and mortality, particularly in older adults and patients with adverse cytogenetic profiles.
AML is a highly heterogeneous disease, encompassing different entities, as has been recognized by the recent WHO and ICC classifications. Novel insights on the genetic complexity and molecular mechanisms of disease and on clonal evolution are required in order to identify new potential targets and disease vulnerabilities aimed at improving the efficacy of treatment, especially among high-risk entities. Furthermore, in order to better evaluate the response to treatment, developing novel biomarkers and methods for the assessment of minimal residual disease is fundamental, as currently available and validated methods are not completely satisfactory, as they are either lacking enough sensitivity or are applicable only to a minority of patients.
This Special Issue aims to present current advances in knowledge on AML, encouraging articles on AML biology, novel therapeutic strategies, and emerging biomarkers, with the ultimate scope of providing a comprehensive overview of the state-of-the-art in AML research.
Dr. Fabio Guolo
Guest Editor
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Keywords
- acute myeloid leukemia (AML)
- hematologic malignancy
- AML classification
- myeloid precursors
- hematopoiesis
- high-risk AML
- biomarkers
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