New Trends and Advances in Induced Neural Cells and iPSC Technologies

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Neuroscience".

Deadline for manuscript submissions: 28 August 2026 | Viewed by 2242

Editor


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Guest Editor
Department of Stem Cell Biology and Regenerative Medicine, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
Interests: stem cell; induced pluripotent stem cell (iPSC); brain organoid; disease modeling; regenerative medicine; immune therapy; drug discovery
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Special Issue Information

Dear Colleagues,

Neurological disorders, and particularly neurodegenerative diseases, place a substantial burden on our aging society. Recent advances in induced pluripotent stem cell (iPSC) technology have opened unprecedented opportunities to study and model these conditions, providing a potentially unlimited source of cells for therapeutic applications. Precision genome editing represents a promising avenue to directly target and correct the underlying causes of disease. Emerging in vivo editing strategies, such as prime editing, enable precise modification of the human genome at specific loci. In parallel, the reprogramming of other cell types into neural cells (induced neural cells) offers an alternative and valuable source for cell-based therapies and drug discovery.

In this Special Issue, we invite original research articles and comprehensive reviews that showcase recent progress, innovative concepts, and breakthrough discoveries in these rapidly advancing fields. We hope that this collection will serve as a platform for disseminating cutting-edge developments and inspiring further innovation in neurological disease research and therapy.

Dr. Guoqiang Sun
Guest Editor

Jonas Cerneckis
Guest Editor Assistant

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Keywords

  • induced neural cells
  • induced pluripotent stem cell (iPSC)
  • neurological disease modeling

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Published Papers (1 paper)

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Review

30 pages, 10620 KB  
Review
Gene Editing Strategies for Neurological and Mental Disorders: Advances in Delivery, Methodology, and Clinical Translation
by Amer Elias and Shani Stern
Cells 2026, 15(8), 720; https://doi.org/10.3390/cells15080720 - 19 Apr 2026
Cited by 1 | Viewed by 1674
Abstract
Neurological and mental disorders are among the main causes of disability worldwide, affecting over three billion people and increasing the socioeconomic burden. Advances in molecular genetics and genome engineering have led to gene-targeted therapies that address root causes rather than just symptoms. This [...] Read more.
Neurological and mental disorders are among the main causes of disability worldwide, affecting over three billion people and increasing the socioeconomic burden. Advances in molecular genetics and genome engineering have led to gene-targeted therapies that address root causes rather than just symptoms. This review covers current genome-editing tools, including CRISPR/Cas, base editing, and prime editing. The focus is on the benefits of gene editing in the central nervous system, where post-mitotic neurons allow lasting effects after a single treatment. It also discusses emerging delivery platforms such as viral vectors, nanoparticles, and exosome systems, as well as methods to bypass the blood–brain barrier. Recent clinical progress in spinal muscular atrophy, Parkinson’s disease, Huntington’s disease, and Alzheimer’s disease is highlighted, with promising preclinical results for autism, bipolar disorder, epilepsy, and other neurogenetic conditions. The review concludes with regulatory issues, market trends, and ongoing clinical trials, underscoring the potential of gene therapies to transform disease management and provide long-term solutions. Full article
(This article belongs to the Special Issue New Trends and Advances in Induced Neural Cells and iPSC Technologies)
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