Signal Transduction and Targeted Therapy for Tumors
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 1439
Special Issue Editor
Interests: molecular cell biology; cell signaling; cancer biology; cell migration; tumor biology; metastasis; pharmacology; cancer cell biology; cancer immunology; cell culture
Special Issue Information
Dear Colleagues,
Cancer represents a global health concern, with its contribution to worldwide mortality increasing each year. Due to its variety and multifactorial nature, cancer represents a complex challenge in biomedical research. Cancer therapeutics involve not only targeting tumor cells but also disrupting the communication between cancer cells and non-transformed cells that are hijacked during tumor progression, such as leukocytes (immunotherapy) or endothelial cells (anti-angiogenic therapy), thereby altering the tumor microenvironment, increasing the anti-tumor response, and reducing the dissemination of tumor cells. Analyzing the signal transduction pathways involved in angiogenic, immunosuppressive, and neurogenic switches triggered by the interaction between tumor cells and adjacent tissue cells may reveal novel therapeutic opportunities to halt and reverse tumor progression.
This Special Issue will investigate the wide range of signal transduction processes linked to cancer and explore the effectiveness of emerging therapeutic targets, drugs, and treatment combinations against cancer-associated processes, such as metastasis, migration and invasion, resistance or persistence, tumor angiogenesis, immunosuppression, tumor neurogenesis/axonogenesis, perineural invasion, and neuropathic pain. By investigating signal transduction processes linked to cancer, we may be able to develop creative targeted therapies to counteract cancer progression.
This Special Issue will showcase reviews and original research articles using cells and animal models.
Dr. Rodolfo Daniel Cervantes-Villagrana
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer progression
- metastasis
- invasion
- cancer signaling
- cell communication
- cancer neuroscience
- tumor angiogenesis
- target therapy
- immunotherapy
- drug resistance
- anti-tumor therapy
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