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Sources of Collagen for Biomaterials in Skin Wound Healing

1
Biology Department, St. Francis Xavier University, Antigonish, NS B2G 2W5, Canada
2
Regenerative Biomaterials Group, The RAFT Institute, Mount Vernon Hospital, Northwood HA6 2RN, UK
*
Author to whom correspondence should be addressed.
Bioengineering 2019, 6(3), 56; https://doi.org/10.3390/bioengineering6030056
Received: 23 May 2019 / Revised: 25 June 2019 / Accepted: 26 June 2019 / Published: 30 June 2019
(This article belongs to the Special Issue Bioengineering Nano and Micro-Gels for Biomedical Applications)
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Abstract

Collagen is the most frequently used protein in the fields of biomaterials and regenerative medicine. Within the skin, collagen type I and III are the most abundant, while collagen type VII is associated with pathologies of the dermal–epidermal junction. The focus of this review is mainly collagens I and III, with a brief overview of collagen VII. Currently, the majority of collagen is extracted from animal sources; however, animal-derived collagen has a number of shortcomings, including immunogenicity, batch-to-batch variation, and pathogenic contamination. Recombinant collagen is a potential solution to the aforementioned issues, although production of correctly post-translationally modified recombinant human collagen has not yet been performed at industrial scale. This review provides an overview of current collagen sources, associated shortcomings, and potential resolutions. Recombinant expression systems are discussed, as well as the issues associated with each method of expression. View Full-Text
Keywords: collagen; collagen sources; recombinant collagen; biomaterials; regenerative medicine; tissue engineering; wound healing; skin collagen; collagen sources; recombinant collagen; biomaterials; regenerative medicine; tissue engineering; wound healing; skin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Davison-Kotler, E.; Marshall, W.S.; García-Gareta, E. Sources of Collagen for Biomaterials in Skin Wound Healing. Bioengineering 2019, 6, 56.

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