Special Issue "Organs-on-Chips"

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editor

Guest Editor
Dr. Virginia Pensabene

School of Electrical and Electronic Engineering, University of Leeds, United Kingdom
Website | E-Mail
Interests: organs-on-chip; hybrid microfabrication; sensors; permeable membranes; ultrathin films; bioadhesives; reproductive toxicology; microphysiological systems

Special Issue Information

Dear Colleagues,

The organs-on-a-chip field is only 10 years old, but it developed at lightning speed. Facing the need of the pharma industry and the academic world for more realistic and reliable human models for drug discovery, testing, and screening, tremendous effort and funding have been dedicated to the development of brain, liver, kidney, heart, and gut models as the main targets of therapeutics. Several groups later approached this technology to clarify the pathogenesis and phatophysiology of human diseases affecting other organs and systems (e.g., vasculature, skin, bone, cartilage, and reproductive organs). Interestingly, the organs-on-a-chip community grouped together experts from different disciplines and boosted innovation in nano/microfabrication, tissue engineering, and material science. Effective micro and meso fluidic models are now commercially available and enable long term growth and control of phenotypic characteristics of multiple cell types.

Thanks to their potential to revolutionize drug development, disease modeling, and personalized medicine, organs-on-a-chip have drastically reduced the use of animals in academic and industrial R&D, replaced traditional in vivo validation and preclinical trials in animals, and supported the refinement of in vitro methods and techniques.

By connecting organs, it is now possible to study how the physiology of a single organ is linked to its metabolism, its response to drugs or toxins, its immune system, and the hormal regulation of other organs.

This Special Issue thus aims to depict the current scenario in this field of animal and human organs-on-a-chip models. Reports on the development of anchillary technologies, such as on-chip or downstream sensing, perfusion systems, and engineering approaches to support cell development, are welcome. New strategies and revised approaches for manufacturing organs-on-a-chip will be included, including new techniques to solve the limitations of traditionally used plastics (e.g., molecules adsorption, hydrophobicity, and transparency), using alternative, sustainable, manufacturing processes and materials. Examples of contributions could address:

  • Animal and human organs-on-a-chip models
  • Validation of organs-on-a-chip models for drug testing and drug screening, toxicity, and toxicology studies
  • Novel methods of analysis of the organs’ effluents
  • Non perturbative analytical methods
  • Sensors integration and techniques for in situ monitoring
  • Multiple organs connections and validation

Dr. Virginia Pensabene
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organs-on-a-chip
  • microfluidic
  • microphysiological systems
  • body-on-a-chip
  • drug discovery
  • animal testing

Published Papers (1 paper)

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Review

Open AccessReview Brain Organoids—A Bottom-Up Approach for Studying Human Neurodevelopment
Bioengineering 2019, 6(1), 9; https://doi.org/10.3390/bioengineering6010009
Received: 28 November 2018 / Revised: 8 January 2019 / Accepted: 11 January 2019 / Published: 18 January 2019
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Abstract
Brain organoids have recently emerged as a three-dimensional tissue culture platform to study the principles of neurodevelopment and morphogenesis. Importantly, brain organoids can be derived from human stem cells, and thus offer a model system for early human brain development and human specific [...] Read more.
Brain organoids have recently emerged as a three-dimensional tissue culture platform to study the principles of neurodevelopment and morphogenesis. Importantly, brain organoids can be derived from human stem cells, and thus offer a model system for early human brain development and human specific disorders. However, there are still major differences between the in vitro systems and in vivo development. This is in part due to the challenge of engineering a suitable culture platform that will support proper development. In this review, we discuss the similarities and differences of human brain organoid systems in comparison to embryonic development. We then describe how organoids are used to model neurodevelopmental diseases. Finally, we describe challenges in organoid systems and how to approach these challenges using complementary bioengineering techniques. Full article
(This article belongs to the Special Issue Organs-on-Chips)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Alison Eastman, David M Aronoff. Leveraging Bioengineering to Assess Cellular Functions and Communication Within Human Gestational Membranes.
Bioengineering EISSN 2306-5354 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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