Design, Optimization and Scale-Up of Industrial Bioprocess

Dear Colleagues,

Bioreactor scale-up from the laboratory scale to the industrial scale has always been a pivotal step in bioprocess development. However, loss of production performance upon scaling-up, including reduced titer, yield, or productivity, has often been observed, hindering the commercialization of biotech innovations. Therefore, new strategies for monitoring, design, evaluation, optimization and scale-up of industrial bioprocess are urgently needed. This Special Issue is aimed at providing an overview of the most recent advances in the field of bioprocess engineering.

The journal will be accepting contributions covering potential topics including, but not limited to:

• Engineering robustness of microbial cell factories;
• Biosensors and real-time monitoring;
• Transport phenomena and CFD simulation;
• Bioprocess kinetics and modeling;
• Bioprocess scale-up/scale-down;
• Bioprocess optimization and scale-up;
• Digital twin and big data analytics;
• Hybrid modeling and smart manufacturing.

Original research contributions will be prioritized, but critical reviews about the state of the art, current limitations, and future perspectives are also welcome.

Dr. Guan Wang
Dr. Cees Haringa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.