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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Reactive Oxygen Species and Growth Factors in Photodynamic Therapy (PDT), Photobiomodulation (PBM), and Radiation Therapy (RT)

edited by Timothy C. Zhu and Brian C. Wilson

submission deadline 31 Oct 2025 | 4 articles | Viewed by 5524 | Submission Open

Keywords: reactive oxygen species (ROS); singlet oxygen (SO); radiation; photodynamic therapy; cancers

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant Activities of Phytochemicals in Fruits and Vegetables

edited by

Wen Qin

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3496 | Submission Open

Keywords: ROS and oxidative stress; green and efficient extraction technology of phytochemicals; antioxidant activity of phytochemicals in fruits and vegetables; polyphenols and polysaccharides in fruits and vegetables; phytochemicals and inflammation

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Implication of Oxidative Stress in Promoting Cellular Senescence and Associated Pathologies—2nd Edition

edited by

Alexandra Barbouti

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2845 | Submission Open

Keywords: oxidative stress; free radicals; reactive oxygen species (ROS); cellular senescence; ageing; age-related pathologies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Natural Antioxidants in Fruits and Vegetables in Human Health

edited by

Antonio Barberis

submission deadline 31 Oct 2025 | 2 articles | Viewed by 2361 | Submission Open

Keywords: antioxidants; anti-inflammation; oxidative stress; fruits; vegetables; oxidation reactions; functional foods

Green Extraction of Antioxidant from Natural Source

edited by

Jolanta Flieger

submission deadline 31 Oct 2025 | 4 articles | Viewed by 2180 | Submission Open

Keywords: green extraction techniques ; supercritical fluid extraction ; ionic liquid (IL)-based extraction; microwave-assisted extraction; antioxidants; plants; cosmetic formulation

Valorization of Waste Through Antioxidant Extraction and Utilization

edited by

Andrés Moreno

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1967 | Submission Open

Keywords: valorization; waste management; green extraction; antioxidants; value-added products; by-products

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Cellular ROS and Antioxidants: Physiological and Pathological Role—2nd Edition

edited by

Andrey V. Kozlov

Mihály Boros

and

Salvatore Nesci

submission deadline 31 Oct 2025 | 1 articles | Viewed by 624 | Submission Open

Keywords: reactive oxygen and nitrogen species; intracellular signaling; oxidative stress; iron metabolism; mitochondrial dysfunction; hypoxia; inflammation; targeted and untargeted antioxidants; gas messengers natural and artificial sources of reactive oxygen species; antioxidant defense systems; small signaling molecules; oxidative stress-driven processes

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Unveiling the Essential Role of Coenzyme Q in Health

edited by

Guillermo López Lluch

and

Steen Larsen

submission deadline 31 Oct 2025 | Viewed by 495 | Submission Open

Keywords: coenzyme Q10; CoQ biosynthesis; ROS; cognitive deficiency; cardiovascular disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Sperm: Technical, Biological and Clinical Aspects—2nd Edition

edited by

Monica Muratori

submission deadline 31 Oct 2025 | Viewed by 193 | Submission Open

Keywords: male infertility; ROS; oxidative sperm DNA damage; sperm DNA fragmentation; sperm epigenetic damage; assisted reproductive techniques; in vitro sperm manipulation; antioxidants; embryo development; pregnancy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Applications and Health Benefits of Novel Antioxidant Biomaterials—2nd Edition

edited by

Washington Luiz Esteves Magalhães

and Tielidy Lima

submission deadline 31 Oct 2025 | Viewed by 163 | Submission Open

Keywords: antioxidant biomaterials; tissue regeneration; biocompatibility; controlled release; premature aging

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Respiratory Diseases—Second Edition

edited by

Sabina Galiniak

and

Stephen M. Black

submission deadline 31 Oct 2025 | Viewed by 105 | Submission Open

Keywords: reactive oxygen species; inflammation; antioxidant therapy; chronic obstructive pulmonary disease; asthma; cystic fibrosis; nitrosative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Modulation of Gut Microbiota and Oxidative Stress to Counteract or Prevent Human Disease

edited by

Simone Carradori

Annalisa Chiavaroli

Alessandra Ammazzalorso

and

Marialucia Gallorini

submission deadline 31 Oct 2025 | Viewed by 79 | Submission Open

Keywords: medicinal chemistry; enzyme modulators; neurodegenerative disorders; microbiota; gut– brain axis; inflammation; probiotic metabolomics; prebiotics; postbiotics; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

From Waste to Health: Upcycling Agrifood By-Products into Functional Antioxidant-Rich Ingredients and Products

edited by

Ítala Marx

and

Feliciano Priego-Capote

submission deadline 31 Oct 2025 | Viewed by 73 | Submission Open

Keywords: antioxidant activity; oxidative stress; reactive oxygen species; polyphenols; bioactive compounds; functional ingredients; health-promoting formulations; agrifood waste; green extraction technologies; emerging analytical methods

Plants and Plant-Based By-Products as Valuable Sources of Antioxidants: Current Tendencies and Achievements in Their Exploitation

edited by Svetlana Momchilova and

Adriana Slavova-Kazakova

submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open

Keywords: antioxidants; oxidative stability; antioxidant activity; lipid oxidation; green chemistry; biomass; plants and by-products; herbs; utilization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Vitamins, Antioxidants, and Neurodegeneration: Exploring Protective Strategies in Brain Health

edited by

Maria Morello

submission deadline 31 Oct 2025 | Viewed by 63 | Submission Open

Keywords: neurodegenerative diseases; alzheimer's disease; parkinson's disease; amyotrophic lateral sclerosis (ALS); aging populations; vitamins; antioxidants; oxidative stress; neuroinflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress Induced by Micro(Nano)plastics

edited by

Lavinia Casati

Alessandro Villa

and

Marco Parolini

submission deadline 31 Oct 2025 | Viewed by 60 | Submission Open

Keywords: micro(nano)plastics; oxidative stress; One Health; in vitro and in vivo models; organisms; cellular microenvironment

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Olive Antioxidants: Extraction, Biological Activity and Practical Applications—3rd Edition

edited by

Juan Fernández-Bolaños

and

Alejandra Bermudez-Oria

submission deadline 31 Oct 2025 | Viewed by 56 | Submission Open

Keywords: antioxidant effect; olive oil; olive by-products; olive leaves; polyphenols; carotenoids; polysaccharide– polyphenol complexes; vitamin E; health; Mediterranean diet

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Redox Regulation in COPD: Therapeutic Implications of Antioxidants

edited by

Samuel Santos Valença

submission deadline 31 Oct 2025 | Viewed by 56 | Submission Open

Keywords: COPD; oxidative stress; antioxidants; pulmonary diseases; therapeutics

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants in Cardiovascular Medicine: Emerging Trends and Future Perspectives

edited by

Matteo Becatti

and

Claudia Fiorillo

submission deadline 31 Oct 2025 | Viewed by 53 | Submission Open

Keywords: cardiovascular disease; CVD; atherosclerosis; hypertension; heart failure; ischemic heart disease; vascular aging; myocardial remodeling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in the Astonishing World of Phytochemicals: State-of-the-Art for Antioxidants—3rd Edition

edited by

Antonella D'Anneo

and

Marianna Lauricella

submission deadline 31 Oct 2025 | Viewed by 40 | Submission Open

Keywords: bioactive compounds; phytochemicals; antioxidant properties; oxidative and nitrosative stress; anticancer action; antimicrobial properties; anti-inflammatory actions

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Chronic Pain and Oxidative Stress

edited by

Olga Pol

submission deadline 31 Oct 2025 | Viewed by 35 | Submission Open

Keywords: analgesia; antioxidants; chemotherapy; heme oxygenase 1; neuropathy; nociception; Nrf2 transcription factor; oxidative stress; pain

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Oxidative Stress in Cardiac Remodeling and Heart Failure—3rd Edition

edited by

Marina Politi Okoshi

Elida Paula Benquique Ojopi

and

Luana Urbano Pagan

submission deadline 31 Oct 2025 | Viewed by 27 | Submission Open

Keywords: oxidative stress; heart disease; cardiac remodeling; signaling pathways; remodeling; left ventricular dysfunction; heart failure; cardiovascular disease; myocardial damage

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Bioactive Compounds from Natural Sources with Antioxidant and Anti-Inflammatory Potential

edited by

Chun Guang Li

submission deadline 31 Oct 2025 | Viewed by 14 | Submission Open

Keywords: antioxidant; anti-inflammatory; natural compounds; isolation; extraction; molecular mechanism; synergistic effect; clinical trial; bioavailability; analytical method; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Alcohol-Induced Oxidative Stress in Health and Disease, 2nd Edition

edited by

Marco Fiore

submission deadline 20 Nov 2025 | 1 articles | Viewed by 1649 | Submission Open

Keywords: alcohol; alcohol use disorder; reactive oxygen species; antioxidant defense

Oxidative Stress from Environmental Exposures

edited by

Giulia Squillacioti

Valeria Bellisario

and

Federica Ghelli

submission deadline 20 Nov 2025 | Viewed by 91 | Submission Open

Keywords: environmental exposures; human health; air pollution; lifestyle; oxidative stress; particulate matter; environmental stressors

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Hepatic Diseases

edited by

Miquel Mulero

submission deadline 21 Nov 2025 | 1 articles | Viewed by 1113 | Submission Open

Keywords: oxidative stress; hepatic diseases; liver fibrosis; reactive oxygen species (ROS); mitochondrial dysfunction; lipid peroxidation; antioxidant defense; non-alcoholic fatty liver disease (NAFLD); alcoholic liver disease; hepatoprotective strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants from Food and Food Wastes for Nutraceutical, Pharmaceutical and Cosmetic Fields

edited by Monica Locatelli and

Vincenzo Disca

submission deadline 25 Nov 2025 | 4 articles | Viewed by 3245 | Submission Open

Keywords: phenolic compounds; analytical methods; bioactivities; green extraction; functional ingredients; food supplements; by-products and up-cycled ingredients; nutraceutical; cosmetics; bioaccessibility

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Antioxidants and Retinal Diseases—2nd Edition

edited by

Francisco J. Romero

and Jorge M. Barcia

submission deadline 30 Nov 2025 | 7 articles | Viewed by 10754 | Submission Open

Keywords: retinal diseases; antioxidants; oxygen species; extracellular vesicles; miRNA

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapy for Obesity-Related Diseases

edited by

Seyed Khosrow Tayebati

submission deadline 30 Nov 2025 | 7 articles | Viewed by 9875 | Submission Open

Keywords: obesity; inflammation; oxidative stress; organ damage; natural antioxidants; synthetic antioxidants; mechanisms of action; therapeutical approaches

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Cancer

edited by

and

submission deadline 30 Nov 2025 | 3 articles | Viewed by 8232 | Submission Open

Keywords: ascorbate; vitamin C; cancer therapy; cancer prevention; antioxidants; prooxidants; oxidative stress; epigenetic activity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Antioxidants for Animal Nutrition—2nd Edition

edited by

Matteo Dell'Anno

and

Luciana Rossi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6189 | Submission Open

Keywords: nutrition; functional diets; innovative antioxidants; feed additives; natural extracts; disease prevention; oxidative stress; one health

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Innovative Technologies for Detecting Antioxidant Properties and Oxidative Stabilization of Agri-Food Products and Plant Extracts

edited by

Chao Hui Feng

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3337 | Submission Open

Keywords: green extraction; plant extracts; bioactive compounds; flavonoids; polyphenols; detection technologies; antioxidant activity

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

The Interaction Between Gut Microbiota and Host Oxidative Stress

edited by

Jie Yin

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2381 | Submission Open

Keywords: oxidative stress; antioxidants; gut microbiome; immunity

Oxidative Stress and Antioxidants in Hypoxia and Human Pathophysiology Settings, 2nd Edition

edited by

Rodrigo L. Castillo

and Alejandro Gonzalez-Candia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1805 | Submission Open

Keywords: tissue hypoxia; reperfusion injury; hypoxic preconditioning; oxidative stress; antioxidants; hypoxic programing; microRNA; clinical hypoxic settings

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Glutathione and Health: From Development to Disease

edited by

Ying Chen

and Vasilis K. Vasiliou

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1371 | Submission Open

Keywords: glutathione; antioxidants; antioxidant enzymes; oxidative stress; redox biology; molecular biology; cellular biology; biochemistry; development; disease

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Eye Diseases

edited by

Dhirendra Pratap Singh

and

Eri Kubo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1337 | Submission Open

Keywords: oxidative stress; antioxidants; reactive oxygen species; redox signaling; inflammatory cell death; age-related blinding diseases; glaucoma; cataract; age-related macular degeneration; gene regulation; retinal disorder; dry eye disorder; corneal diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Foods and Cardiometabolic Health—3rd Edition

edited by

Yolanda Aguilera Gutiérrez

and

Maria Angeles Martín-Cabrejas

submission deadline 30 Nov 2025 | Viewed by 457 | Submission Open

Keywords: cardiometabolic diseases; antioxidant foods; bioactive compounds; functional foods; biological activity; bioaccessibility

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—3rd Edition

edited by

Gina Cavaliere

and

Giovanna Trinchese

submission deadline 30 Nov 2025 | Viewed by 92 | Submission Open

Keywords: mitochondria function; oxidative processes; metabolic diseases; reactive oxygen species; therapeutic approaches; mitochondrial integrity; energy production; mitochondrial bioenergetic; metabolism; mitochondrial dynamic

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Products to Mitigate Oxidative Stress and Inflammation in Non-Communicable Intestinal Diseases

edited by

Carlos Martins-Gomes

and

Amélia M. Silva

submission deadline 30 Nov 2025 | Viewed by 45 | Submission Open

Keywords: natural bioactives; phytochemicals; oxidative stress; inflammation; non-communicable intestinal diseases; colorectal cancer; inflammatory bowel diseases; signalling pathways

Berry Antioxidants in Health and Disease—2nd Edition

edited by

Dorothy Klimis-Zacas

and

Sarah A. Johnson

submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open

Keywords: berries; antioxidants; polyphenols; berry metabolites; oxidative stress; chronic diseases; cardiovascular disease; metabolic syndrome; diabetes mellitus; cancer; neurodegenerative disease; gut microbiome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Bioactive Antioxidants: Structural Characterization, Synthetic Pathways, and Clinical Applications

edited by

Jolanta Flieger

submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open

Keywords: bioactive antioxidants; therapeutic potential; synthetic strategies; structural characterization

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Lipid Peroxidation, Vegetable Oil Oxidation, and the Role of Plant Extracts in Enhancing Oxidative Stability

edited by

Daniele Sanna

and

Angela Fadda

submission deadline 30 Nov 2025 | Viewed by 1 | Submission Open

Keywords: oil oxidative stability; natural antioxidants; lipid peroxidation; surfactants; encapsulation

(This special issue belongs to the Section Aberrant Oxidation of Biomolecules)

Oxidative Stress in Cell Senescence

edited by

Sara Cruciani

submission deadline 30 Nov 2025 | Viewed by 1 | Submission Open

Keywords: stem cells; cell senescence; regenerative medicine; antioxidant strategies; age-related diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Artificial Intelligence and Other Bioinformatic Modern Technologies Approaches to the Study of Antioxidant Capacity in Food Production

edited by

Giuseppe Perretti

submission deadline 5 Dec 2025 | Viewed by 349 | Submission Open

Keywords: artificial intelligence; bioinformatics; food processing; food quality; antioxidant capacity; big data

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Phytochemical Analysis and Evaluation of Antioxidant Properties in Medicinal Plants

edited by

Magdalena Jeszka-Skowron

Agnieszka Zgoła-Grześkowiak

Tomasz Grześkowiak

and

Robert Frankowski

submission deadline 20 Dec 2025 | 7 articles | Viewed by 10842 | Submission Open

Keywords: antioxidant activity; phytochemicals in plants; medicinal plants; extraction; in vivo analysis; in vitro analysis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidant and Anti-Inflammatory Properties of Mushrooms: From Structure to Functionality

edited by

Michał Swieca

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3615 | Submission Open

Keywords: mushroom; antioxidants; metabolic syndrome; functional food; nutraceuticals; polysaccharides; phenolics; terpenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Interplay of Microbiome and Oxidative Stress

edited by

Julio Plaza-Díaz

Lourdes Herrera-Quintana

and

Héctor Vázquez Lorente

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2353 | Submission Open

Keywords: microbiome; oxidative stress; antioxidants; gut microbiota; free radicals; reactive oxygen species; gut– brain axis; dysbiosis; microbial metabolites; mitochondrial function; probiotics; microbe– host interactions

Significance of Antioxidant Mechanisms in Intestinal Inflammation—2nd Edition

edited by

Alba Rodríguez-Nogales

and

María Elena Rodríguez Cabezas

submission deadline 20 Dec 2025 | Viewed by 27 | Submission Open

Keywords: antioxidant therapy; antioxidants; intestinal inflammation; oxidative stress; polyphenol; reactive oxygen/nitrogen species; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Plant Redox Biology Research in China

edited by Yurong Xie and Ming Chang

submission deadline 20 Dec 2025 | Viewed by 13 | Submission Open

Keywords: plant redox biology; reactive oxygen species; reactive nitrogen species; plant development; environmental stress; abiotic/biotic stresses; host– microbe interactions

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidants as Adjuvants for Inflammatory Bowel Disease Treatment

edited by

Marcello Chieppa

and

Angelo Santino

submission deadline 22 Dec 2025 | 3 articles | Viewed by 2824 | Submission Open

Keywords: IBD; antioxidant; gut barrier; inflammation; natural compounds; microbiome; colon cancer; adjuvant; nutritional bioactive products; polyphenols

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

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