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Antioxidants, Volume 14, Issue 8

August 2025 - 134 articles

Cover Story: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disorder with limited therapeutic options and heterogeneous treatment responses. In this study, we investigated the hepatoprotective effects of red ginseng, focusing on the role of saponin fractions in distinct diet-induced MASLD mouse models. Saponin treatment improved steatosis, inflammation, and fibrosis, particularly in the high-fat-diet model, and reduced hepatic iron accumulation. Transcriptomic and molecular analyses identified HAMP1 as a potential exploratory biomarker associated with therapeutic response. These findings were further validated using patient-derived human liver organoids, supporting translational relevance. Our results highlight biomarker-driven stratification as a strategy to optimize red ginseng therapy in MASLD… View this paper
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Articles (134)

  • Article
  • Open Access
1,153 Views
15 Pages

21 August 2025

Fermented vinegars have been highlighted globally for their health benefits. The benefits can differ according to the type of vinegar; therefore, we investigated the differences of 15 grain (GV), 10 persimmon (PV), and 14 apple vinegars (AV) using in...

  • Article
  • Open Access
1,023 Views
12 Pages

Cumulative Low-Dose-Rate Radiation Induces Oxidative Stress, Apoptosis, and Fibrosis in Mouse Testis

  • Eun-Jin Kim,
  • Anjas Happy Prayoga,
  • Jina Ha,
  • Deok Gyeong Kang,
  • Jinsung Yang,
  • Sohi Kang,
  • Jin-Mok Kim,
  • Byeonggyu Ahn,
  • Dang Long Cao and
  • Seung Pil Yun
  • + 3 authors

21 August 2025

Ionizing radiation is a well-known environmental stressor capable of generating excessive reactive oxygen species (ROS), leading to oxidative damage in sensitive tissues, including the reproductive system. While oxidative stress is increasingly impli...

  • Article
  • Open Access
862 Views
21 Pages

Using Integrated Bioinformatics Analysis to Identify Saponin Formosanin C as a Ferroptosis Inducer in Colorectal Cancer with p53 and Oncogenic KRAS

  • Hsin-Chih Chen,
  • Ching-Ying Chen,
  • Pao-Yuan Wang,
  • Pin-Yu Su,
  • Shu-Ping Tsai,
  • Chi-Pei Hsu,
  • Hsiao-Sheng Liu,
  • Chi-Ying F. Huang,
  • Wen-Hsing Cheng and
  • Ming-Fen Lee
  • + 1 author

21 August 2025

Ferroptosis, a form of cell death, is characterized by lipid peroxidation and is dependent on iron and reactive oxygen species (ROS). Here, through bioinformatics analysis, formosanin C was predicted to be a ferroptosis inducer in colorectal cancer (...

  • Article
  • Open Access
1 Citations
811 Views
18 Pages

Dietary Carnosic Acid Supplementation Improves the Growth Performance, the Antioxidant Status, and Diversity of Intestinal Microbiota in Broilers

  • Sheng Zhang,
  • Qin Wang,
  • Jingjing Dong,
  • Guanhuo Li,
  • Kaiyuan Niu,
  • Junhao Pan,
  • Linghan Xia,
  • Yibing Wang and
  • Shouqun Jiang

21 August 2025

Carnosic acid (CA), a natural phenolic terpenoid compound, is widely distributed in plants such as sage and rosemary, and exhibits a strong antioxidant capacity. The aim of this study was to investigate the effects of different levels of CA on growth...

  • Systematic Review
  • Open Access
1,006 Views
22 Pages

Therapeutic Potential of Apocynin: A Promising Antioxidant Strategy for Acute Kidney Injury

  • Jelena Nesovic Ostojic,
  • Sanjin Kovacevic,
  • Silvio R. De Luka,
  • Milan Ivanov,
  • Aleksandra Nenadovic and
  • Andrija Vukovic

21 August 2025

Acute kidney injury (AKI) is characterized by a sudden rise in serum creatinine levels, a reduction in urine output, or both. Despite its frequent occurrence in clinical settings, AKI remains poorly understood from a pathophysiological standpoint. As...

  • Article
  • Open Access
1,559 Views
30 Pages

Role of Endoplasmic Reticulum Stress-Associated Genes in Septic Neonatal Foals

  • Dipak Kumar Sahoo,
  • David Wong,
  • Biswaranjan Paital,
  • Rebecca E. Ruby and
  • Ashish Patel

21 August 2025

The progression of inflammation during sepsis represents a multifaceted biological cascade that requires effective therapeutic interventions to improve survival. In septic neonatal foals, oxidative stress (OS) arises due to a compromised antioxidant...

  • Article
  • Open Access
1 Citations
1,227 Views
24 Pages

Identification, Quantification, and Antioxidant Evaluation of Phenolic Compounds from Colored Opuntia ficus-indica (L.) Roots Using UHPLC-DAD-ESI-MS/MS

  • Elias Benramdane,
  • Ahmad Mustafa,
  • Nadia Chougui,
  • Nawal Makhloufi,
  • Abderezak Tamendjari and
  • Cassamo U. Mussagy

21 August 2025

This study investigates the phenolic composition and antioxidant potential of root extracts from three Opuntia ficus-indica varieties (green, red, and orange) using ultra-high-performance liquid chromatography coupled with diode array detection and e...

  • Article
  • Open Access
966 Views
18 Pages

21 August 2025

Hyperglycemia in early-stage embryogenesis is linked to diabetic embryopathy. High-glucose-concentration-induced accumulation of hexokinase-2 (HK2) may initiate metabolic dysfunction that contributes to diabetic embryopathy, including increased forma...

  • Article
  • Open Access
926 Views
19 Pages

21 August 2025

Chronic inflammation is closely associated with various diseases, underscoring the need for natural, biocompatible anti-inflammatory candidates. For this purpose, mussel foot protein could be an excellent candidate due to its diverse biological activ...

  • Article
  • Open Access
824 Views
15 Pages

Transcriptomic and Proteomic Insights into 6PPD/6PPD-Q Induced Oxidative Stress in Black-Spotted Frogs

  • Wenhui Sun,
  • Bingyi Wang,
  • Sihan Zhang,
  • Zhiquan Liu,
  • Yinan Zhang and
  • Hangjun Zhang

20 August 2025

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPD-Q) can have lethal effects on aquatic organisms, interfering with gene expression and protein content in aquatic animals. In this study, we p...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license