Antioxidants and Age-Related Changes in Skeletal Muscle and Vascular Health

Dear Colleagues,

Aging is one of the main risk factors for the development of cardiovascular diseases. One suggested mechanism by which aging induces vascular pathologies is promoting an imbalance between the synthesis of reactive oxygen and nitrogen species and antioxidant protection, leading to oxidative stress, reduced nitric oxide bioavailability, and endothelial dysfunction. The reduction in the endothelium-dependent vasodilatory response, associated with the impairment of angiogenic processes and the subsequent pathological remodeling of the microcirculation, contributes to the reduction of tissue perfusion and impairs the functional capacity of older people. Furthermore, oxidative stress with advancing age is associated with other biological changes that can reduce skeletal muscle size, strength, and quality. Given the undesirable vascular and physical consequences of aging, establishing non-pharmacological strategies for prevention and treatment is essential for the health and well-being of the older population. Thus, this Special Issue of Antioxidants, entitled “Dietary Antioxidants and Age-Related Changes in Skeletal Muscle and Vascular Health”, welcomes high-quality original papers and review articles that can contribute to the understanding of the role of dietary antioxidants in preventing age-related changes in skeletal muscle quality and vascular function.

Dr. Thiago Silveira Álvares
Guest Editor

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