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Antioxidants
Special Issues
Antioxidants from the Perspective of Environmental Physiology and Pathology
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Antioxidants from the Perspective of Environmental Physiology and Pathology

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 January 2026 | Viewed by 720

Special Issue Editor

Dr. Gianfranco Santovito

E-Mail Website
Guest Editor
Associate Professor, Department of Biology, University of Padova, 35131 Padova, Italy
Interests: oxidative stress; fish physiology; anthropogenic environmental stress; evolutionary biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antioxidants are pivotal in counteracting oxidative stress, a pathological condition triggered by an imbalance between reactive oxygen species (ROS) production and the body’s ability to neutralize them. Environmental factors such as pollution, ultraviolet radiation, and toxins significantly contribute to the overproduction of ROS, leading to molecular and cellular damage. This process is also implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.

In an environmental physio-pathological context, antioxidants serve as a critical defence mechanism. These molecules, either enzymatic (e.g., superoxide dismutases, catalase, glutathione peroxidases, peroxiredoxins) or non-enzymatic (e.g., vitamins C and E, glutathione, metallothioneins), scavenge free radicals and prevent oxidative damage to cellular structures such as DNA, proteins, and lipids. Dietary antioxidants derived from plant-based sources enhance the body’s ability to mitigate environmental insults.

Chronic exposure to pollutants and other environmental stressors often overwhelms endogenous antioxidant systems, emphasizing the importance of external supplementation. Research is increasingly focusing on developing antioxidant-based therapeutic strategies and interventions to bolster resilience against environmental stress.

This Special Issue aims to gather contributions addressing the interactions between antioxidants and environmental stressors in animals and humans and offer insights into how the body can cope with oxidative stress to ensure an optimal health status.

Dr. Gianfranco Santovito
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • environmental stress
  • pollutants
  • health
  • oxidative stress

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Published Papers (1 paper)

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Research

18 pages, 1857 KiB  
Article
The Role of Air Pollution Exposure and GSTM1-/GSTT1-Null Genotypes in Gestational Diabetes Mellitus Development: A Case–Control Study on Gene–Environment Interactions
by Ana Susa, Dragana Davidovic, Nadja Nikolic, Tamara Sljivancanin Jakovljevic, Vera Kujundzic, Sladjana Mihajlovic and Ljiljana Bogdanovic
Antioxidants 2025, 14(6), 652; https://doi.org/10.3390/antiox14060652 - 28 May 2025
Viewed by 474
Abstract
As gestational diabetes mellitus (GDM) rises as a major public health concern, various factors have been identified as potential contributors, with air pollution drawing increasing attention. The mechanisms by which air pollutants lead to detrimental impacts are largely attributed to oxidative stress. However, [...] Read more.
As gestational diabetes mellitus (GDM) rises as a major public health concern, various factors have been identified as potential contributors, with air pollution drawing increasing attention. The mechanisms by which air pollutants lead to detrimental impacts are largely attributed to oxidative stress. However, the role of air pollution is still not entirely clarified, suggesting that additional factors, such as genetic variability, particularly of genes involved in redox homeostasis, influence the GDM risk. This study addresses three questions: (1) whether ambient PM2.5, PM10, O3, and NO2 exposures associate with GDM risk; (2) if GSTM1-/GSTT1-null genotypes affect the risk of GDM; and (3) whether these genotypes modify pollution–GDM associations. This case–control study comprised 133 women in the case group and 144 in the control group. Exposure to air pollutants was assessed based on the participants’ residential addresses and during different time windows: pre-pregnancy period, first trimester, and second trimester. GSTM1/GSTT1 genotyping was conducted from blood samples. Higher PM2.5, PM10, and O3 levels increased GDM risk in women. While GSTM1-/GSTT1-null genotypes showed no overall link to GDM, non-smokers with GSTM1-null had higher GDM risk when exposed to PM2.5 during the first trimester. While further research on gene–environment interactions is needed, our findings highlight that reducing air pollution may lower GDM risk. Full article
(This article belongs to the Special Issue Antioxidants from the Perspective of Environmental Physiology and Pathology)
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