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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hydrogen and Oxidative Stress: Implications for Health and Longevity

edited by

Kyu-Jae Lee

and

Cheol-Su Kim

submission deadline 25 Dec 2025 | 2 articles | Viewed by 2277 | Submission Open

Keywords: molecular hydrogen (H2); oxidative stress; redox homeostasis; selective antioxidant; reactive oxygen species (ROS); aging and longevity; mitochondrial protection; cellular resilience; hydrogen therapy; inflammation and immunity; neurodegeneration; cardiovascular health; metabolic disorders; gene regulation; translational medicine; longevity

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant Response in Aquatic Animals

edited by Martha Gabriela Gaxiola-Cortes

submission deadline 30 Dec 2025 | 9 articles | Viewed by 15438 | Submission Open

Keywords: antioxidant system; respiration; nutrition; culture; fish; aquatic animals; reactive oxygen species (ROS); superoxide dismutase (SOD)

Nitric Oxide and Redox Mechanisms

edited by

Massimiliano Coletta

, Paolo Ascenzi and

Giovanna De Simone

submission deadline 30 Dec 2025 | 6 articles | Viewed by 14824 | Submission Open

Keywords: nitric oxide; ROS and RNS; nitrosative stress; NO signaling; redox mechanisms

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant and Anti-Inflammatory Potential of Plants in Cancer Treatment

edited by

Brigitte Deguin

Lorenza Trabalzini

and

Rosa Tundis

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7924 | Submission Open

Keywords: phytochemical characterization; antioxidant and anti-inflammatory natural compounds and extracts; natural waste resources; horticultural or wild plants; medicinal plants; and edible plants; green selective extraction processes

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Male Reproductive Health

edited by

and

submission deadline 31 Dec 2025 | 10 articles | Viewed by 34214 | Submission Open

Keywords: oxidative stress; antioxidant therapy; male reproductive health; male fertility; erectile dysfunction; prostatic disease; male ageing

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapies in Cardiovascular, Cardiorenal and Metabolic Diseases

edited by Kaushik P. Patel, Hong Zheng and

Tapan Patel

submission deadline 31 Dec 2025 | 5 articles | Viewed by 20930 | Submission Open

Keywords: antioxidant therapies; oxidative stress; cardiovascular diseases; cardiorenal diseases; metabolic diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Carotenoids in Health and Disease

edited by Kazutoshi Shindo

submission deadline 31 Dec 2025 | 3 articles | Viewed by 13284 | Submission Open

Keywords: antioxidant activities of carotenoids; analytical chemistry on carotenoids; reactive oxygen species (ROS) and disease; production of carotenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Multi-Target Profile of Antioxidant Compounds, Including Repurposing and Combination Strategies—2nd Edition

edited by

Roberta Rocca

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11310 | Submission Open

Keywords: polypharmacology; multi-target ligands; rational drug; design repurposing; off-target effects; computational techniques

Agri-Food Wastes as Natural Source of Bioactive Antioxidants: Fourth Edition

edited by

Silvana Hrelia

Cristina Angeloni

and

Maria Cristina Barbalace

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10551 | Submission Open

Keywords: agri-food by-products; agri-food waste; nutraceuticals; functional foods; cosmeceutical products; sustainable practices; bioactive compounds; health effects

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025)

edited by

Alessandra Napolitano

and

Mario Allegra

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9644 | Submission Open

Keywords: obesity; cardiovascular diseases; chronic disease; dietary prevention; antioxidants intake; gut microbiome; natural and synthetic antioxidants; antioxidant enzyme systems; antioxidant extraction

Redox Regulation in Cardiovascular Diseases

edited by

Yiliang Chen

and

Jacek Zielonka

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9227 | Submission Open

Keywords: oxidative stress; mitochondria; metabolism; chronic inflammation; atherosclerosis; CVD; ROS

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress, Antioxidants, and Mechanisms in FLASH Radiotherapy

edited by

Jean Paul Jay-Gerin

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7974 | Submission Open

Keywords: radiobiology and radiotherapy; ultra-high dose rate irradiation and the FLASH effect; molecular and cellular mechanisms; radiation-induced oxidative stress; reactive oxygen and nitrogen species; inflammatory processes; antioxidants and radioprotectors; pulse radiolysis; kinetics; physicochemical and biological processes; DNA damage; role of oxygen and the oxygen depletion hypothesis; modeling and experimental; FLASH particle therapy

Role of Reactive Oxygen Species (ROS) in Tumor Microenvironment Modulation

edited by

Antonis Giakountis

and

Dimitrios Kouretas

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7252 | Submission Open

Keywords: reactive oxygen species; tumor microenvironment; stroma cells; functional genomics; spatial transcriptomics; single-cell sequencing; RNA-seq; cancer; diagnosis and prognosis; biomarkers

Antioxidant Activity of Polyphenolic Extracts

edited by

Dimitrios Stagos

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7080 | Submission Open

Keywords: antioxidant activity; polyphenols; plant extracts; oxidative stress

Oxidative Stress in Rare Diseases: Mechanisms, Implications, and Therapeutic Opportunities

edited by

Christophe Desterke

and

Jorge Mata-Garrido

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5925 | Submission Open

Keywords: rare diseases; oxidative stress; free radicals; biomedicine; redox biomarkers; redox epigenetics; redox metabolism; redox control of protein function; ferroptosis

Redox Biology and Genomic Integrity

edited by

Viktor Stolc

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5691 | Submission Open

Keywords: redox biology; reactive oxygen species (ROS); oxidative stress; oxidative DNA damage; genome stability; DNA repair; hypermutation; antioxidant defense mechanisms; mitochondrial dysfunction; Saccharomyces cerevisiae; cellular adaptation; epigenetics; telomeres

Natural Antioxidants in Animal Nutrition

edited by

Lili Zhang

Xiang Zhong

, Chao Wang, Hao Zhang and Jingfei Zhang

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5522 | Submission Open

Keywords: antioxidants; animal; growth; metabolism; nutrition; oxidative stress; plant extracts

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Editorial Board Members’ Collection Series: Advances in Redox-Tools and Therapies in Cardiovascular Disease

edited by

Andreas Daiber

Albino Carrizzo

and

Moo-Yeol Lee

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3728 | Submission Open

Keywords: cardiovascular disease; oxidative stress; inflammation; reactive oxygen species; redox signalling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Strategies for Oxidative Stress Management: Dietary Interventions for Liver and Gut Health

edited by

Antonio Cilla

and

Mussa Makran

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3446 | Submission Open

Keywords: antioxidant compounds; phytochemicals; dietary interventions; hepatic disease; intestinal disease; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Metabolic Dysfunction and Oxidative Stress

edited by

Vinood B. Patel

and

Mohammed Gulrez Zariwala

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2994 | Submission Open

Keywords: iron; mitochondria; oxidative stress; inflammation; metabolism; free radicals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Respiratory Disorders

edited by

Daniela Mokra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2977 | Submission Open

Keywords: oxidative stress; lung; reactive oxygen species; reactive nitrogen species; acute lung injury; asthma; COPD; lung fibrosis; pulmonary silicosis; premature neonate

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Radiation Exposure and Health: The Role of Oxidative Stress and Inflammatory Response

edited by

Siamak Haghdoost

and

Benjamin Frey

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2238 | Submission Open

Keywords: radiation; inflammatory response; oxidative stress

Natural Antioxidants in Functional Foods

edited by

Angela Cardinali

, Palmira De Bellis and

Anna Rita Bavaro

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1961 | Submission Open

Keywords: polyphenols; functional foods; fermentation; antioxidant activity; anti-inflammatory activity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Super Oxide Dismutase (SOD) Isoenzymes and Reactive Oxygen Species (ROS) in Immuno-Pathophysiology

edited by Giuseppina Ruggiero and

Paolo Mondola

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1935 | Submission Open

Keywords: superoxide dismutase (SOD) isoenzymes; superoxide dismutase (SOD)1; cell signalling; cell metabolism; cell functions; cellular stress; disease pathogenesis

Modulation of Biochemical, Cellular and Physiological Mechanisms in Response to Oxidative Stress in Animals

edited by

Konstantinos Feidantsis

and

Vasiliki Sapanidou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1734 | Submission Open

Keywords: animals; cell signaling; metabolism; cell death responses; oxidative damage

Phenolic Antioxidants in Functional Foods and Nutraceuticals

edited by

Diana Andreia Tavares Pinto

and

Francisca Rodrigues

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1109 | Submission Open

Keywords: bioactive compounds; agri-food byproducts; in vitro assays; in vivo studies; green extraction; biological activities; safety assessment; industrial application

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Stress and Mitochondrial Dysfunction in Metabolic Disorders

edited by

Pablo M. García-Rovés

Steen Larsen

and Hugo J Alves-Figueiredo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1021 | Submission Open

Keywords: metabolic diseases; oxidative stress; mitochondrial dysfunction; antioxidant therapies; lifestyle interventions; gene therapies; mitochondrial transfer therapies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Algal Antioxidants: Physiology, Metabolism, and Evolution

edited by

Shan Lu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 909 | Submission Open

Keywords: algae; antioxidant; oxidative stresses; algal physiology

Emerging Trends in Antioxidant Nutraceuticals

edited by

Andrei Mocan

and

Oleg Frumuzachi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 789 | Submission Open

Keywords: nutraceuticals; diabetes; cancer; oxidative stress; inflammation; antioxidant

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants and Dietary Nutrition: Emerging Trends, and Clinical Applications

edited by

Sofia Lotti

and

Raúl Zamora-Ros

submission deadline 31 Dec 2025 | Viewed by 476 | Submission Open

Keywords: antioxidants; oxidative stress; chronic disease prevention; dietary strategies; bioavailability

Antioxidant Properties of Functional Foods

edited by Konstantinos G. Adamopoulos and

Patroklos Vareltzis

submission deadline 31 Dec 2025 | Viewed by 444 | Submission Open

Keywords: antioxidant; extraction; bioavailability; processing; optimization; functional food; phytochemicals

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Metabolic Reprogramming and Epigenetic Crosstalk in the Tumor Microenvironment

edited by

Federico Pio Fabrizio

Lucia Anna Muscarella

Filippo Torrisi

and Sebastiano Giallongo

submission deadline 31 Dec 2025 | Viewed by 341 | Submission Open

Keywords: metabolomics; tumor cell metabolism; tumor microenvironment; cell communication; cell signaling; epigenetics; post-translational modifications; cancer therapy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Dietary Antioxidants in Alleviating Oxidative Stress and Inflammation for Enhanced Immunity in Animals

edited by Yanka D. Karamalakova and

Jie Yin

submission deadline 31 Dec 2025 | Viewed by 329 | Submission Open

Keywords: antioxidants; antioxidant feeding; insect meal; growth performance; digestible energy; nutrient digestibility; blood biochemistry; oxidative stress (OS); lipid peroxidation (MDA); ROS/RNS; superoxide dismutase (SOD); catalase (CAT); glutathione (GSH); glutathione peroxidase (GPx); inflammation markers; total antioxidant capacity (TAC); meat; milk; eggs quality

Development and Application of Detection Methods for Reactive Oxygen Species and Antioxidants

edited by

Naoya Kishikawa

and

Mahmoud El-Maghrabey

submission deadline 31 Dec 2025 | Viewed by 306 | Submission Open

Keywords: antioxidant extraction; antioxidant assay; sensors for reactive oxygen species (ROS); ROS scavenger assays; biological samples; oxidative stress status; nutritional value; food analysis; bioassays; enzymatic assays; redox cycle; cell imaging

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Antioxidant Natural Products and Peptides in Cosmetics

edited by

Fotini Lamari

Vassiliki Magafa

and

Sophia Hatziantoniou

submission deadline 31 Dec 2025 | Viewed by 283 | Submission Open

Keywords: cosmetics; herbal extracts; natural products; peptides; synthesis; isolation; oxidative stress; emulsions; nanoparticles; fibroblasts; ageing

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Bioavailability of Antioxidants: From Omics Insights to Health Outcomes

edited by

Pascual García-Pérez

submission deadline 31 Dec 2025 | Viewed by 252 | Submission Open

Keywords: bioavailability; nutrigenomics; metabolomics; gut microbiota; dietary polyphenols; functional foods; biotransformation; systems biology; antioxidants; bioactivity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Studies on Antioxidants and Anti-Aging Substances Using Model Organisms and Cell Cultures

edited by

Yoshihiro H. Inoue

submission deadline 31 Dec 2025 | Viewed by 229 | Submission Open

Keywords: antioxidants; anti-aging substances and natural products; experimental animals; 3D cell culture models; organoids; acting mechanisms; antioxidant genes; autophagy; proteasome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Regulation of Plant Growth and Development

edited by Judit Dobránszki and

Judit Remenyik

submission deadline 31 Dec 2025 | Viewed by 173 | Submission Open

Keywords: plant biology; ascorbate; free-radical scavenging; glutathione; heat shock proteins; melatonin; oxidative stress; plant growth and development; redox homeostasis; RNP; ROS; plant stress mitigation; plant stress adaptation; transcription factors

(This special issue belongs to the Section ROS, RNS and RSS)

Hydrogen Sulfide and Its Role in Inflammatory and Degenerative Joint Diseases

edited by Guenter Steiner and Burkhard Klösch

submission deadline 31 Dec 2025 | Viewed by 165 | Submission Open

Keywords: hydrogen sulfide; inflammation; antioxidant; osteoarthritis; rheumatoid arthritis; degeneration; chondrocyte; monocyte; fibroblast; drug development

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Biomarkers of Oxidative Stress in Lung Disease

edited by

Rafał Pawliczak

submission deadline 31 Dec 2025 | Viewed by 135 | Submission Open

Keywords: oxidative stress; reactive oxygen species; reactive nitrogen species; antioxidants; lung inflammation; bronchial inflammation; COPD; asthma; lung fibrosis; mitochondria

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Adaptive Responses in Space Medicine and Physiology

edited by

Dawon Kang

submission deadline 31 Dec 2025 | Viewed by 129 | Submission Open

Keywords: antioxidant defense ; microgravity ; oxidative stress ; radiation ; space medicine ; space physiology

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Phytochemicals for Promoting Human Health and Well-Being

edited by

Teresa Mencherini

Francesca Sansone

and

Tiziana Esposito

submission deadline 10 Jan 2026 | 6 articles | Viewed by 10215 | Submission Open

Keywords: antioxidant phytochemicals; oxidative stress; health promotion; chronic disease; functional foods; nutraceuticals

Antioxidant Effects of Natural Compounds on Cell Metabolism

edited by Ester Tellone and Annamaria Russo

submission deadline 12 Jan 2026 | 3 articles | Viewed by 6504 | Submission Open

Keywords: antioxidants; metabolic pathways; dietary intake; blood cells; bioactive compounds

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Mitochondrial Oxidative Stress in Aging and Disease—2nd Edition

edited by

Angela Maria Serena Lezza

and

Vito Pesce

submission deadline 15 Jan 2026 | 7 articles | Viewed by 20026 | Submission Open

Keywords: mitochondrial oxidative stress in aging; mitochondrial oxidative stress in age-related or metabolic diseases; mitochondrial signaling via ROS in diseases; mitochondrial oxidative stress and genomic instability; mitochondrial oxidative stress and inflammation; antioxidants as novel therapeutic approaches; mitochondrial pathologies; aging; mitochondrial

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrophilic and Lipophilic Antioxidants in Foods and Food Processing

edited by

Volker Böhm

submission deadline 15 Jan 2026 | 1 articles | Viewed by 766 | Submission Open

Keywords: antioxidant activity; antioxidant capacity; antioxidant mechanisms; carotenoids; polyphenols; vitamin C; vitamin E; impact of food processing

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Exploring the Role of Polyphenols in Oxidative Stress and Cellular Protection

edited by

Lucia Gimeno-Mallench

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2217 | Submission Open

Keywords: polyphenol; oxidative stress; cellular signaling; metabolic pathways

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants and Multifunction Photoprotection—2nd Edition

edited by

André Rolim Baby

and

Catarina Rosado

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1714 | Submission Open

Keywords: natural and synthetic antioxidants; sunscreens; multifunctional products; safety and efficacy establishment; product technologies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Peroxiredoxin Biology

edited by Mikael Molin and Cecilia Picazo

submission deadline 23 Jan 2026 | 1 articles | Viewed by 624 | Submission Open

Keywords: oxidative stress; aging; age-related diseases; H2O2 signaling; redox regulation

(This special issue belongs to the Section Antioxidant Enzyme Systems)

Interplay Between Gut Microbiota and Oxidative Stress

edited by

Sunmin Park

submission deadline 25 Jan 2026 | Viewed by 297 | Submission Open

Keywords: gut microbiota; redox; human health; gut homeostasis

Redox Balance and Autophagy in Neuroinflammation

edited by

Anna Colell

and

Vicente Roca-Agujetas

submission deadline 26 Jan 2026 | Viewed by 275 | Submission Open

Keywords: oxidative stress/oxidative damage ; reactive oxygen species (ROS) ; redox homeostasis ; autophagy ; lysosomal clearance ; proteinopathies ; neuroinflammation ; neurological disorders ; cellular homeostasis ; neuroprotection

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

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