Lipoproteins and Redox Imbalance in Health and Disease: Mechanisms and Therapeutic Opportunities
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 72
Special Issue Editors
Interests: lipoproteins; atherosclerotic cardiovascular disease
Special Issue Information
Dear Colleagues,
Rationale and aim: Lipoproteins, beyond their classical role in lipid transport, are central players in redox regulation and inflammation across a wide range of pathological conditions. Structural and functional alterations of lipoproteins—including oxidative modifications—are key contributors to the pathogenesis of cardiovascular, metabolic, neurodegenerative, and inflammatory diseases.
This Special Issue aims to provide a comprehensive overview of the interplay between lipoproteins and redox homeostasis in both physiological and pathological contexts. We welcome original research articles and review papers that explore how lipoproteins modulate or are affected by oxidative stress, with a special emphasis on molecular mechanisms, diagnostic potential, and therapeutic applications.
Topics of Interest:
- Oxidative modifications of LDL, HDL, and VLDL, and their biological consequences.
- Dysfunctional lipoproteins in cardiovascular, renal, metabolic, or neurodegenerative diseases.
- The antioxidant and/or pro-oxidant properties of HDL.
- Lipoproteins and chronic low-grade inflammation.
- Lipoprotein-based redox biomarkers in plasma and cerebrospinal fluid.
- Molecular mechanisms of lipid peroxidation mediated by lipoproteins.
- Lipoprotein-associated enzymes (e.g., LCAT, PON1, CETP, LPL, Lp-PLA2) and redox balance.
- Lipoproteins, microbiota–host interaction, and redox signaling.
- Nutritional, pharmacological, and biotechnological strategies to restore lipoprotein redox function.
- Therapeutic potential of recombinant or engineered lipoproteins.
Dr. Chiara Pavanello
Dr. Alice Ossoli
Guest Editors
Manuscript Submission Information
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Keywords
- lipoproteins
- redox
- lipid metabolism
- oxidative stress
- inflammation
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