Antioxidants and Multifunction Photoprotection—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 1104

Special Issue Editors


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Guest Editor
Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-900, Brazil
Interests: photoprotection; dermocosmetics; efficacy tests; cutaneous attributes
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Guest Editor
CBIOS—Research Center for Biosciences and Health Technologies, Lusófona University, Lisbon, Portugal
Interests: skin delivery systems; efficacy and safety testing; biomaterials as topical, transdermal, and cosmetic ingredients; nutrition and skin health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Humans are constantly affected by their lifestyle and various forms of radiation from both natural and artificial sources. Environmental pollution, for example, can induce skin injuries such as inflammation and oxidative stress, which may be exacerbated by exposure to radiation. Ultraviolet (UV) radiation (UVA and UVB) remains one of the primary exogenous agents responsible for the generation of reactive species, photochemical damage to genetic material, disruption of collagen and elastin fibers, accelerated cutaneous aging, and an increased risk of skin cancer. Oxidative stress is significantly amplified by UV radiation exposure. While UV filters are the main active ingredients that protect the skin against UV radiation, the molecules currently present in sunscreens are not entirely effective against cutaneous oxidative stress. Moreover, protecting the skin against the full spectrum of radiation presents significant challenges. Beyond UV, visible light, and infrared radiation are also increasingly recognized for their detrimental effects on skin, contributing to oxidative stress, hyperpigmentation, and collagen degradation. Developing comprehensive photoprotection that effectively mitigates the damage from these multiple radiation sources, while maintaining product aesthetics and safety, is a complex task. Consequently, innovative investigations are needed to develop safe and multifunctional products that offer the greatest spectrum of protection and multiple benefits. Strategies for enhancing this protection profile involve the inclusion of antioxidant compounds from synthetic, waste, or natural origins into products, as well as new technologies for improving their safety and range of benefits. Furthermore, advancements in assessing sunscreen efficacy are crucial. This second edition will also welcome emerging and alternative methods for obtaining sunscreen efficacy data.

This second edition of the Special Issue titled "Antioxidants and Multifunction Photoprotection—2nd Edition" invites you to contribute your latest research findings or review papers. We seek to highlight the newest data and critical state-of-the-art information on investigations into the use of antioxidants for photoprotection, the development of multi-benefit products, and advancements in emerging and alternative methods for multifunctional sunscreen efficacy testing.

We look forward to receiving your contributions.

Dr. André Rolim Baby
Dr. Catarina Rosado
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural and synthetic antioxidants
  • sunscreens
  • multifunctional products
  • safety and efficacy establishment
  • product technologies

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Published Papers (1 paper)

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Research

17 pages, 3462 KB  
Article
β-Nicotinamide Mononucleotide Enhances Skin Barrier Function and Attenuates UV-B-Induced Photoaging in Mice
by Sung Jin Kim, Sullim Lee, Yea Jung Choi, Minseo Kang, Junghwan Lee, Gwi Seo Hwang, Seok-Seon Roh, Mu Hyun Jin, Sangki Park, Minji Park, Ho Song Cho and Ki Sung Kang
Antioxidants 2025, 14(12), 1424; https://doi.org/10.3390/antiox14121424 - 27 Nov 2025
Viewed by 889
Abstract
Ultraviolet B (UV-B) radiation significantly contributes to skin photoaging, which is characterized by epidermal thickening, collagen degradation, wrinkle formation, barrier dysfunction, and oxidative stress. Nicotinamide mononucleotide (NMN), a key precursor of nicotinamide adenine dinucleotide, regulates cellular energy metabolism and antioxidant defense and demonstrates [...] Read more.
Ultraviolet B (UV-B) radiation significantly contributes to skin photoaging, which is characterized by epidermal thickening, collagen degradation, wrinkle formation, barrier dysfunction, and oxidative stress. Nicotinamide mononucleotide (NMN), a key precursor of nicotinamide adenine dinucleotide, regulates cellular energy metabolism and antioxidant defense and demonstrates anti-aging effects in animal models. Here, we investigated the protective effects of oral NMN supplementation against UV-B-induced photoaging in SKH-1 hairless mice. Over a 10-week experimental period, oral NMN administration significantly alleviated epidermal hypertrophy, reduced wrinkle formation and skin surface roughness, improved hydration and elasticity, and restored transepidermal water loss to near-normal levels. Histological analyses revealed marked preservation of collagen fiber density and attenuation of dermal matrix degradation. Furthermore, NMN supplementation inhibited the phosphorylation of MAPK signaling components (ERK, JNK, and p38), suppressed pro-inflammatory cytokine (TNF-α and IL-6) and matrix-degrading enzyme (MMP-1) expression, and restored hyaluronan synthase (HAS-1 and HAS-2) expression. Additionally, NMN enhanced the systemic antioxidant defense, as indicated by the restored superoxide dismutase activity. Thus, NMN has multi-layered protective effects against UV-B–induced skin aging by modulating oxidative stress, inflammatory signaling, extracellular matrix remodeling, and hyaluronic acid metabolism. Full article
(This article belongs to the Special Issue Antioxidants and Multifunction Photoprotection—2nd Edition)
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