Antioxidant Phytochemicals for Promoting Human Health and Well-Being

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 10 January 2026 | Viewed by 207

Special Issue Editors


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Guest Editor
Department of Pharmacy, University of Salerno, Fisciano, Italy
Interests: secondary metabolite isolation from medicinal plants and food byproducts; analytical techniques; structural determination; NMR spectroscopy; nutraceuticals; bioactive natural molecules
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, Salerno, Italy
Interests: drug delivery systems for pharmaceutical; nutraceutical and cosmetic applications; application of micro/nano-encapsulation techniques in particle engineering; biopolymers; medicinal plant extracts; spray drying; technological and solid state characterization
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
Interests: drug delivery systems for pharmaceutical; nutraceutical and cosmetic applications; application of micro/nano-encapsulation techniques in particle engineering; biopolymers; medicinal plant extracts; spray drying; technological and solid solid-state characterization; secondary metabolite isolation from medicinal plants and food byproducts; analytical techniques
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antioxidant phytochemicals are naturally occurring compounds that play a pivotal role in neutralizing oxidative stress and preventing cellular damage caused by free radicals. Their health-promoting properties have attracted significant interest in the fields of nutrition, human health, and well-being.

This Special Issue focuses on the recovery of antioxidant phytochemicals from plants, agri-food by-products, and other natural sources, highlighting their potential in promoting health and preventing chronic disease. They key topics involved in this Special Issue include the following:

Innovative Extraction Methods: Advanced techniques for recovering antioxidant phytochemicals from natural sources, emphasizing the use of bio- and eco-compatible solvents and processes, along with the chemical characterization of bioactive molecules.

Mechanisms of Action: Insights into how these phytochemicals mitigate oxidative damage through free radical scavenging, regulating antioxidant enzymes, and modulating cellular signaling pathways involved in inflammation, apoptosis, aging-related decline, and other disorders.

Formulation Design and Technological Characterization: The development and evaluation of innovative delivery systems to improve the stability, bioavailability, and functionality of antioxidant phytochemicals for applications in functional foods, nutraceuticals, cosmetics, and pharmaceutical products.

Challenges and Future Directions: Exploration of novel phytochemicals, their interactions with human systems, and the development of stable and bioactive formulations for nutrition, cosmetics, and pharmaceuticals.

By consolidating cutting-edge findings, this Special Issue aims to provide a comprehensive understanding of how antioxidant phytochemicals can be harnessed to improve human health and well-being. It seeks to pave the way for innovative solutions in disease prevention and health promotion.

Dr. Teresa Mencherini
Dr. Francesca Sansone 
Dr. Tiziana Esposito
Guest Editors

Manuscript Submission Information

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Keywords

  • antioxidant phytochemicals
  • oxidative stress
  • health promotion
  • chronic disease
  • functional foods
  • nutraceuticals

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Published Papers (1 paper)

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Research

17 pages, 1404 KiB  
Article
The Mechanism of Protective Action of Plant-Derived Squalane (2,6,10,15,19,23-Hexamethyltetracosane) Against UVA Radiation-Induced Apoptosis in Human Dermal Fibroblasts
by Katarzyna Wolosik, Magda Chalecka, Gabriela Gasiewska, Jerzy Palka and Arkadiusz Surazynski
Antioxidants 2025, 14(7), 853; https://doi.org/10.3390/antiox14070853 - 11 Jul 2025
Abstract
Ultraviolet A (UVA) radiation has been identified as a significant factor contributing to skin photoaging and skin diseases, operating through the excessive generation of reactive oxygen species (ROS) and the subsequent induction of DNA damage. Plant-derived antioxidants have demonstrated efficacy in mitigating UVA-induced [...] Read more.
Ultraviolet A (UVA) radiation has been identified as a significant factor contributing to skin photoaging and skin diseases, operating through the excessive generation of reactive oxygen species (ROS) and the subsequent induction of DNA damage. Plant-derived antioxidants have demonstrated efficacy in mitigating UVA-induced damage; nevertheless, their instability limits their therapeutic potential. This study investigates the mechanisms of antioxidant and cytoprotective effects of squalane (Sq), a stable, plant-derived triterpene, in human dermal fibroblasts (HDFs) exposed to UVA radiation. Sq was administered at concentrations ranging from 0.005% to 0.015% prior to UVA exposure (10 J/cm2). It has been found that Sq counteracted UVA-induced ROS formation, decreased the level of reduced thiol groups, activated apoptosis, and inhibited DNA biosynthesis. Immunofluorescence analysis revealed that Sq suppressed the UVA-induced expression of p53, caspase-3, caspase-9, and PARP, while restoring the activity of the pro-survival p-Akt/mTOR pathway. The findings indicate that Sq exerts protective effects on UVA-induced fibroblast damage through a combination of antioxidant and anti-apoptotic mechanisms. Full article
(This article belongs to the Special Issue Antioxidant Phytochemicals for Promoting Human Health and Well-Being)
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