Advances in Peroxiredoxin Biology
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: 23 January 2026 | Viewed by 159
Special Issue Editors
Interests: proteostasis; H2O2 signaling; peroxiredoxin biology
Special Issue Information
Dear Colleagues,
Peroxiredoxins (Prxs) are a group of antioxidant enzymes vital for protecting cells from oxidative stress. Acting as thiol-specific peroxidases and modulators of hydrogen peroxide (H2O2) signaling, they convert harmful peroxides, particularly H2O2, organic hydroperoxides, and peroxynitrite, into harmless compounds, utilizing electron donors such as thioredoxin. Prxs are divided into three primary categories based on their catalytic mechanisms: typical 2-Cys, atypical 2-Cys, and 1-Cys peroxiredoxins. Widely conserved across all forms of life, Prxs are crucial for sustaining redox balance and modulating signaling pathways linked to H2O2. Beyond their peroxidase function, they also serve as chaperones and redox receptors and transducers. During oxidative stress, Prxs can undergo reversible hyperoxidation, temporarily halting their peroxidase activity while potentially boosting their chaperone role.
Reduced Prx activity is associated with aging and various age-related diseases, including cancer, neurodegenerative conditions, and cardiovascular disorders, whereas mildly boosting Prx activity slows down aging and reduces the incidence of age-related diseases. Due to their role in regulating cell signaling and stress responses, they are promising candidates as aging-related biomarkers and therapeutic targets. In essence, peroxiredoxins are versatile proteins that play a key role in combating oxidative stress, maintaining cellular signaling, and preventing redox-related damage.
Dr. Mikael Molin
Guest Editor
Dr. Cecilia Picazo
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- oxidative stress
- aging
- age-related diseases
- H2O2 signaling
- redox regulation
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