Advances in Peroxiredoxin Biology

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: 23 January 2026 | Viewed by 13

Special Issue Editors


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Guest Editor
Department of Systems and Synthetic Biology, Chalmers University of Technology, 41296 Gothenburg, Sweden
Interests: proteostasis; H2O2 signaling; peroxiredoxin biology

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Guest Editor Assistant
Institute for Integrative Systems Biology, I2SysBio, University of Valencia-CSIC, 7, 46980 Paterna, Spain
Interests: yeast; biotechnology; aging; oxidative stress; peroxiredoxins

Special Issue Information

Dear Colleagues,

Peroxiredoxins (Prxs) are a group of antioxidant enzymes vital for protecting cells from oxidative stress. Acting as thiol-specific peroxidases and modulators of hydrogen peroxide (H2O2) signaling, they convert harmful peroxides, particularly H2O2, organic hydroperoxides, and peroxynitrite, into harmless compounds, utilizing electron donors such as thioredoxin. Prxs are divided into three primary categories based on their catalytic mechanisms: typical 2-Cys, atypical 2-Cys, and 1-Cys peroxiredoxins. Widely conserved across all forms of life, Prxs are crucial for sustaining redox balance and modulating signaling pathways linked to H2O2. Beyond their peroxidase function, they also serve as chaperones and redox receptors and transducers. During oxidative stress, Prxs can undergo reversible hyperoxidation, temporarily halting their peroxidase activity while potentially boosting their chaperone role.

Reduced Prx activity is associated with aging and various age-related diseases, including cancer, neurodegenerative conditions, and cardiovascular disorders, whereas mildly boosting Prx activity slows down aging and reduces the incidence of age-related diseases. Due to their role in regulating cell signaling and stress responses, they are promising candidates as aging-related biomarkers and therapeutic targets. In essence, peroxiredoxins are versatile proteins that play a key role in combating oxidative stress, maintaining cellular signaling, and preventing redox-related damage.

Dr. Mikael Molin
Guest Editor

Dr. Cecilia Picazo
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • oxidative stress
  • aging
  • age-related diseases
  • H2O2 signaling
  • redox regulation

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Published Papers

This special issue is now open for submission.
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