Oxidative Stress and Diabetic Retinopathy

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 January 2026 | Viewed by 835

Special Issue Editor


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Guest Editor
Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
Interests: ocular regeneration; diabetic retinopathy; corneal diseases

Special Issue Information

Dear Colleagues,

Diabetic retinopathy (DR) is a leading cause of visual impairment among individuals with diabetes, with oxidative stress playing a critical role in its development and progression. Oxidative stress induces retinal microvascular dysfunction and contributes to a complex pathophysiological mechanism that involves increased angiogenesis and inflammation. Emerging evidence suggests that antioxidants may inhibit the onset and slow the progression of DR, positioning them as a promising therapeutic strategy.

This Special Issue explores the preventive and therapeutic potential of antioxidants in the context of diabetic retinopathy, emphasizing the role of oxidative stress in its pathophysiology. It will also address the potential utility of oxidative stress biomarkers for clinical application, the prospects for personalized therapeutic approaches, and the development of innovative antioxidant-based treatments.

By gathering insights at the forefront of basic research, clinical trials, and drug discovery, this Special Issue aims to provide a comprehensive perspective on diabetic retinopathy. The scope of this Special Issue ranges from molecular mechanisms to proposals for novel therapeutic interventions, with the ultimate goal being to reduce the burden of DR and enhance visual outcomes for affected patients.

In this Special Issue, original research articles and reviews are welcome. We warmly invite you to contribute your latest research findings or comprehensive review articles to this Special Issue. Your expertise and insights will be invaluable in advancing our understanding of this important topic.

Dr. Tatsuya Mimura
Guest Editor

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Keywords

  • diabetic retinopaty
  • oxidative stress
  • antioxidants
  • inflammation
  • environmental factor

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Published Papers (1 paper)

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Review

14 pages, 2098 KB  
Review
Oxidative Stress in Diabetic Retinopathy: A Comprehensive Review of Mechanisms, Biomarkers, and Therapeutic Perspectives
by Tatsuya Mimura and Hidetaka Noma
Antioxidants 2025, 14(10), 1204; https://doi.org/10.3390/antiox14101204 - 4 Oct 2025
Viewed by 610
Abstract
Diabetic retinopathy (DR) is a leading cause of vision loss globally and represents one of the most common microvascular complications of diabetes. In addition to metabolic disturbances associated with hyperglycemia, oxidative stress has emerged as a critical contributor to the onset and progression [...] Read more.
Diabetic retinopathy (DR) is a leading cause of vision loss globally and represents one of the most common microvascular complications of diabetes. In addition to metabolic disturbances associated with hyperglycemia, oxidative stress has emerged as a critical contributor to the onset and progression of DR. Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense mechanisms, leads to cellular injury, inflammation, and increased vascular permeability. In the diabetic retina, excessive ROS production promotes endothelial cell apoptosis, breakdown of the blood-retinal barrier (BRB), and induction of angiogenic factors such as vascular endothelial growth factor (VEGF). This review provides a comprehensive overview of the pathophysiology of DR, focusing on the molecular mechanisms of oxidative stress. Relevant studies were identified through a structured search of PubMed, Web of Science, and Scopus (2000–2025) using terms such as ‘diabetic retinopathy’, ‘oxidative stress’, and ‘antioxidants’. We explore current knowledge on oxidative stress-related biomarkers and therapeutic strategies targeting oxidative damage, including antioxidant compounds and mitochondrial protective agents. Recent findings from both experimental and clinical studies are summarized, highlighting the translational potential of oxidative stress modulation in DR management. Finally, future research directions are discussed, including biomarker standardization, personalized medicine approaches, and long-term clinical validation of antioxidant-based therapies. A deeper understanding of oxidative stress may offer valuable insights into novel diagnostic and therapeutic strategies for DR. Full article
(This article belongs to the Special Issue Oxidative Stress and Diabetic Retinopathy)
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