Natural Antioxidants and Aquatic Animal Health—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1457

Special Issue Editor

Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China
Interests: aquatic animals; pharmacology; toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our previous edition received a large number of submissions. Building on this success, I am pleased to announce the second edition of our Special Issue entitled “Natural Antioxidants and Aquatic Animal Health—2nd Edition".

Numerous medicinal plants and their extracts have been confirmed to possess antioxidant properties. They are widely used as drugs or feed additives due to their abundant extraordinary beneficial health effects for humans and animals. In aquaculture, farmed animals are invariably exposed to numerous stressors, such as high stocking densities, temperature fluctuations, and pathogenic infections. To counter these stress-induced adverse effects, medicinal plants and their extracts have increasingly been recognized as eco-friendly and effective alternatives to synthetic chemicals. Over the past few decades, these plants and their derivatives have been commonly used as dietary additives in aquaculture to alleviate oxidative stress, promote growth, and reduce the incidence of diseases. Medicinal plants, rich in various active substances such as polysaccharides, alkaloids, tannins, saponins, glycosides, flavonoids, steroids, and essential oils, have been proven to possess significant antioxidant properties. The selection of natural antioxidants or these medicinal plants will thus be pivotal in future aquaculture development. Future research will also focus on the antioxidant defense mechanisms within aquatic animals and on elucidating the links between natural antioxidants and the health of aquatic animals.

In this Special Issue, we aim to discuss the relationship natural antioxidants and aquatic animal health. The topics of interest include, but are not limited to, the following: 1) the discovery of new natural antioxidants; 2) the key mechanisms through which natural antioxidants impact the health of aquatic animals; 3) the anti-stress and disease resistance mechanisms inherent in aquatic animals; and 4) the influence of natural antioxidants on aquatic species based on multi-omics analyses.

Dr. Rui Jia
Guest Editor

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Keywords

  • natural antioxidants
  • oxidative stress
  • medicinal plants
  • aquatic animals
  • feed additives

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Published Papers (2 papers)

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Research

17 pages, 1020 KiB  
Article
The Significant Enhancing Effect of Vitamin B6-Fortified Feed on the Intestinal Digestive Efficiency, Immunity, and Antioxidant Defense Mechanisms of Juvenile Largemouth Bass (Micropterus salmoides)
by Leimin Zhang, Dongyu Huang, Jiaze Gu, Hualiang Liang and Mingchun Ren
Antioxidants 2025, 14(3), 313; https://doi.org/10.3390/antiox14030313 - 5 Mar 2025
Cited by 2 | Viewed by 667
Abstract
A 12-week aquaculture trial was conducted to evaluate the effects of vitamin B6 on the intestinal health of largemouth bass (Micropterus salmoides). Six feeds with a vitamin B6 content of 2.03 (control group), 2.91, 3.30, 6.03, 9.53, and 21.79 [...] Read more.
A 12-week aquaculture trial was conducted to evaluate the effects of vitamin B6 on the intestinal health of largemouth bass (Micropterus salmoides). Six feeds with a vitamin B6 content of 2.03 (control group), 2.91, 3.30, 6.03, 9.53, and 21.79 mg/kg were prepared. The results were as follows. Regarding digestive efficiency, the 9.53 mg/kg group showed significantly higher activities of AMY, LPS, and TRY compared to the control group; the 6.03 mg/kg group exhibited increased AKP and Na+/K+ ATPase activities. Regarding immunity, the 6.03 mg/kg group had markedly higher relative expressions of zo-1 and occ than the control group; the 9.53 mg/kg group showed significantly higher relative expressions of il-10, tgf-β, igm, and cd83, while il-8 and tnf-α were notably lower, and nf-κb was noticeably decreased in 21.79 mg/kg group. For antioxidant capacity, the 6.03 mg/kg group had markedly higher activities of CAT, SOD, GSH-Px, and T-AOC levels, compared to the control group; the MDA level in the control group was markedly higher than in the other groups. The relative expressions of nrf2, cat, Cu-Zn sod, and gpx were highest in 9.53 mg/kg group and significantly higher than in the control group. In conclusion, an appropriate level of vitamin B6 in the feed is vital for protecting the intestinal health of largemouth bass. Full article
(This article belongs to the Special Issue Natural Antioxidants and Aquatic Animal Health—2nd Edition)
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20 pages, 3563 KiB  
Article
Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (Oreochromis niloticus) Through Multi-Omics Analysis
by Haizheng Wu, Haojun Zhu, Quanjie Li, Jiancao Gao, Jinliang Du, Liping Cao, Yi Sun and Gangchun Xu
Antioxidants 2025, 14(3), 296; https://doi.org/10.3390/antiox14030296 - 28 Feb 2025
Viewed by 497
Abstract
This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. The results showed that 96 h post injection, serum levels of aspartate GOT, GPT, LYZ, T-AOC, and SOD significantly decreased (p < 0.05). [...] Read more.
This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. The results showed that 96 h post injection, serum levels of aspartate GOT, GPT, LYZ, T-AOC, and SOD significantly decreased (p < 0.05). In contrast, hepatic levels of CAT and MDA significantly increased. The 16S rDNA sequencing method revealed a significant reduction in the α diversity of the intestinal microbiota. At the phylum level, the relative abundances of Firmicutes and Bacteroidota significantly decreased; at the genus level, several genera, including Bacteroides and Pseudomonas, also exhibited significant changes. Functional prediction indicated that the affected pathways were primarily related to metabolism and disease. Additionally, targeted metabolomics analysis showed a significant decrease in the levels of several SCFAs, such as butyric acid. Correlation analysis further elucidated the complex interactions between the intestinal microbiota, biochemical indicators, and SCFA metabolism. Overall, the study demonstrated that MC-LR induced oxidative stress and liver damage and led to intestinal microbiota imbalance and metabolic dysfunction in GIFT tilapia. Full article
(This article belongs to the Special Issue Natural Antioxidants and Aquatic Animal Health—2nd Edition)
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