ROS Levels and Thioredoxin Reductases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: 27 February 2026 | Viewed by 3
Special Issue Editors
Interests: thioredoxin reductase; selenoprotein; tumor drug resistance; small molecule inhibitor; ferroptosis; dislfidptosis; oxidative stress; disulfide stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The intricate interplay between Reactive Oxygen Species (ROS) and the Thioredoxin (Trx) system, critically regulated by Thioredoxin Reductases (TrxR), stands at the forefront of understanding pathogenesis and developing novel therapeutics for cancer and inflammatory diseases. Dysregulation of ROS signalling and TrxR activity is a hallmark of tumour progression, metastasis, therapy resistance, and chronic inflammation.
Antioxidants (Impact Factor: 6.6) invites you to submit your latest original research articles and insightful reviews for a special focus on “ROS and thioredoxin reductases” in fields of anti-tumour and anti-inflammatory research. We seek high-quality contributions exploring:
- Novel mechanisms of ROS generation.
- Noval Antioxidants scavenging impacting tumorigenesis or inflammation.
- The role of TrxR isoforms in cancer cell survival, proliferation, and drug resistance.
- Development and evaluation of novel TrxR inhibitors as anti-cancer or anti-inflammatory agents.
- ROS/TrxR signalling crosstalk (e.g., with Nrf2, NF-κB,) in disease contexts.
- Bioactive materials inducing PCDs.such as apoptosis, pyroptosis, ferroptosis and disulfidptosis, etc.
- Targeting the Trx system for overcoming therapy resistance towards clinic drugs.
- Targeting the Trx system for resensitizing cancer cells towards any inducible cell deaths.
- Preclinical and clinical studies elucidating TrxR as a biomarker or therapeutic target.
Share your groundbreaking discoveries to advance this dynamic field! Benefit from rigorous peer review, rapid publication, and high visibility of Antioxidants within the redox biology, bioactive materials and translational medicine communities. Please submit your manuscript by 27 February 2026, via our online portal: https://susy.mdpi.com/user/manuscripts/upload (*Select Journal: Antioxidants; Research Topics*: ROS Levels and Thioredoxin Reductases).
We look forward to your valuable contributions!
Sincerely,
Dr. Jianqiang Xu
Dr. Shui Guan
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- thioredoxin reductase
- oxidative stress
- antioxidants
- bioactive materials
- ferroptosis
- disulfidptosis
- necroptosis
- apoptosis
- autophagy
- inflammation
- diagnosis marker
- oxidative stress
- disulfide stress
- redox regulation
- nanomedicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
